“…However, it is stressed that relevant factors of engineered nanoparticles' (ENP) size, structure, chemical activity and evolution in the environment are not taken into consideration. To model such parameters, new mechanistic approaches (Maggi, 2009;Sithebe and Nkhalambayausi Chirwa, 2016) that would take specific physical and chemical nanoscale phenomena (Bishop et al, 2009;Walker et al, 2010a) into consideration are needed.…”