Hospital Health Promotion (HHP) is an effort by hospital management to improve the ability to accelerate patient recovery and improve their health by implementing clean and healthy living behavior (CHLB). This study aims to analyze the application of health promotion management of CHLB in the era of the covid-19 pandemic. This research used a sequential explanatory design located at the RSU Royal Prima Medan with a quantitative sample of 111 patient assistants and qualitative research informants. Data were obtained using questionnaires and in-depth interviews. Based on the research results that 63 respondents have bad CHLB. Data were analyzed using chi-square found that knowledge and attitude have the most significant influence on the implementation of CHLB with p = 0.002 of attitude, followed by p = 0.014 of knowledge and p = 0.019 of HHP. The results of multiple logistic regression indicate that HHP is the most dominant variable that can affect CHLB. In contrast, p = 0.002 of attitude, p = 0.014 of knowledge, and followed by p = 0.019 of HHP. This research also ensured the significance of CHLB as a new approach that may contribute to the advancement of knowledge on hospital management in the pandemic situation.