IntroductionIn the UK, actual uptake of vaccination against SARS-CoV-2, the novel coronavirus that causes COVID-19, has exceeded expectations formed from studies conducted in 2020. However, it remains lower among members of other than white ethnic groups, and among younger people. Some evidence exists to suggest that the ethnic gap in vaccine uptake might be partially explained by lower trust, while one study carried out before the vaccination programme rollout suggested that variation in vaccine hesitancy can be explained by differences in trust and healthcare experiences, without reference to demographic variables such as age and ethnicity.MethodsIn April 2021, data were collected from 4885 UK-resident adults, of whom 3223 had received the invitation to be vaccinated against the novel coronavirus. Logit models were used to estimate the association between probability of vaccine uptake and age, gender, ethnicity, household income, NHS healthcare experiences, and trust in government, scientists, and medical professionals. Mediation analysis was conducted in order to probe the relationship between ethnicity, NHS healthcare experiences, trust, and uptake.ResultsGender and household income were not predictive of vaccine uptake. Age and ethnicity were predictive of uptake, even after controls: younger people and members of other than white ethnic groups are less likely to have taken up the invitation to be vaccinated. NHS healthcare experiences appear to mediate a relationship between ethnicity and trust, and also to mediate some of the relationship between ethnicity and uptake (via trust).ConclusionsMembers of other than white ethnic groups report inferior NHS healthcare experiences, which may explain their lower trust in government, scientists, and medical professionals. However, this does not fully explain the ethnic gap in coronavirus vaccination uptake.