Medial prefrontal gray matter volume reductions in users of amphetamine-type stimulants revealed by combined tract-based spatial statistics and voxel-based morphometry

Daumann, Jörg; Koester, Philip; Becker, Benjamin; Wagner, Daniel R.; Imperati, Davide; Gouzoulis-Mayfrank, Euphrosyne; Tittgemeyer, Marc

doi:10.1016/j.neuroimage.2010.08.065

Cited by 67 publications

(64 citation statements)

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“…Beside a high overlap with other fMRI studies on decision-making, the results of the present study are also in line with reports on structural deficits in ATS polydrug users (Cowan et al, 2003;Daumann et al, 2011;Kish et al, 2010;Koester et al, 2012). A decrease in gray matter volume (Daumann et al, 2011) and a thinning of the cerebral cortex (Kish et al, 2010;Koester et al, 2012) have been described primarily in the orbito-and mediofrontal cortex, as well as the parietal cortex of MDMA and amphetamine users (Cowan et al, 2003).…”

Section: Discussionsupporting

confidence: 91%

“…A decrease in gray matter volume (Daumann et al, 2011) and a thinning of the cerebral cortex (Kish et al, 2010;Koester et al, 2012) have been described primarily in the orbito-and mediofrontal cortex, as well as the parietal cortex of MDMA and amphetamine users (Cowan et al, 2003). Although the exact mechanisms of neuronal degeneration are not yet fully understood, druginduced changes in synaptic strength and structure have been proposed (Hutton et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…The concomitant use of other drugs, primarily other stimulants, alcohol, and cannabis, is common in this group. Together with environmental factors such as hyperthermia and dehydration, ATS are assumed to exhibit neurotoxic properties even in recreational users (Cowan et al, 2003;Daumann et al, 2011;Kish et al, 2010;Koester et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Abnormalities in ATS polydrug users have been described by structural and functional magnet resonance imaging (MRI), as well as psychopathological and neuropsychological measures (Cowan et al, 2003;Daumann et al, 2011;De Win et al, 2008;Kish et al, 2010;Koester et al, 2012;Moeller et al, 2007). Besides the deficits in memory-related parameters Daumann et al, 2005;Murphy et al, 2012;Wagner et al, 2012) as an assumed result of hippocampal damage, research on neurocognitive deficits associated with ATS polydrug use is mainly focused on poor decision-making (Aron and Paulus, 2007;Quednow et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Decision-making in Polydrug Amphetamine-type Stimulant Users: an fMRI Study

Koester

Volz

Tittgemeyer

et al. 2013

Neuropsychopharmacol

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Qualitative poor decision-making and associated altered neuronal activation patterns have been described for the users of several drugs, amongst others for stimulants like amphetamine and MDMA. Deficits in decision-making might be caused by an augmented attraction to short-term rewarding properties despite negative long-term consequences, leading to rigid stimulus-response patterns. In the present imaging study, we investigated decision-making and associated neuronal activation in three groups differing in their exposure to amphetamine and MDMA. An established paradigm on risky choices was used to evaluate decision-making performance and corresponding functional magnet resonance imaging (fMRI) activation. Subjects could choose between a low-risk control gamble and an experimental gamble, which always differed in the probability of winning or losing, as well as the magnitudes of monetary gain or loss. Experienced users (EU), users with low exposure to stimulants and drug-naive controls, did not differ from each other in behavioral performance. In accordance with our hypotheses, the anticipation of reward led to an activation of primarily the frontal cortex and the striatum in low-exposure users and drug-naive controls. In contrast, frontal and parietal activation was observed in all groups when the actual outcome of an experimental gamble was presented. EU displayed more activation compared to both control groups when there was a high probability of winning. The study at hand supports the hypothesis that neuronal activation patterns might even differ between drug users and healthy controls when no behavioral deficits are apparent. In EU, the probability of the occurrence of an event has more influence on neuronal activation than on the actual magnitude of reinforcing properties of this event.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Decision-making in Polydrug Amphetamine-type Stimulant Users: an fMRI Study

Koester

Volz

Tittgemeyer

et al. 2013

Neuropsychopharmacol

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“…It has been reported that abstinent METH users have lower gray matter density in the FC as well as decreased Wisconsin card sorting test task performance compared with drugfree control subjects . Decreased cingulate and hippocampal volumes that correlated with performance on a verbal memory test (Thompson et al, 2004) and correlations between increased METH exposure and reductions in orbital and medial PFC volumes have also been noted (Daumann et al, 2011). Interestingly, striatal volume is reportedly increased in abstinent METH users in a study that, however, did not find any evidence of decreased cognitive performance (Chang et al, 2005).…”

Section: Action Of Substituted Amphetamines and Cathinonesmentioning

confidence: 95%

Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse

Korpi¹,

Hollander²,

Farooq

et al. 2015

Pharmacol Rev

129

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Regional gray matter volume associated with exercise dependence: A voxel‐based morphometry study

Zhang

Wang

Feng

et al. 2021

Human Brain Mapping

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Although regular physical exercise has multiple positive benefits for the general population, excessive exercise may lead to exercise dependence (EXD), which is harmful to one's physical and mental health. Increasing evidence suggests that stress is a potential risk factor for the onset and development of EXD. However, little is known about the neural substrates of EXD and the underlying neuropsychological mechanism by which stress affects EXD. Herein, we investigate these issues in 86 individuals who exercise regularly by estimating their cortical gray matter volume (GMV) utilizing a voxel-based morphometry method based on structural magnetic resonance imaging. Whole-brain correlation analyses and prediction analyses showed negative relationships between EXD and GMV of the right orbitofrontal cortex (OFC), left subgenual cingulate gyrus (sgCG), and left inferior parietal lobe (IPL). Furthermore, mediation analyses found that the GMV of the right OFC was an important mediator between stress and EXD. Importantly, these results remained significant even when adjusting for sex, age, body mass index, family socioeconomic status, general intelligence and total intracranial volume, as well as depression and anxiety. Collectively, the results of the present study provide crucial evidence of the neuroanatomical basis of EXD and reveal a potential neuropsychological pathway in predicting EXD in which GMV mediates the relationship between stress and EXD.

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Medial prefrontal gray matter volume reductions in users of amphetamine-type stimulants revealed by combined tract-based spatial statistics and voxel-based morphometry

Cited by 67 publications

References 71 publications

Decision-making in Polydrug Amphetamine-type Stimulant Users: an fMRI Study

Decision-making in Polydrug Amphetamine-type Stimulant Users: an fMRI Study

Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse

Regional gray matter volume associated with exercise dependence: A voxel‐based morphometry study

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