Mediation of the microbiome-gut axis by oyster (Crassostrea gigas) polysaccharides: A possible protective role in alcoholic liver injury

Jiang, Suisui; Ma, Yuyang; Li, Yitong; Liu, Ruihai; Zeng, Mingyong

doi:10.1016/j.ijbiomac.2021.04.050

Cited by 35 publications

(25 citation statements)

References 34 publications

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“…Briefly, Lactobacillus , a therapeutically relevant bacterial genus, decreased after alcohol intake, which can be further restored through various bioactive compounds and natural products [ 70 , 74 , 78 , 79 , 96 , 97 ]. Lactobacillus is a beneficial bacteria that produces bacteriocins such as antibiotics, which further inhibit harmful microbes of the Enterobacteriaceae family, such as Salmonella or Shigella [ 107 ].…”

Section: Discussionmentioning

confidence: 99%

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The Beneficial Effects of Natural Extracts and Bioactive Compounds on the Gut-Liver Axis: A Promising Intervention for Alcoholic Liver Disease

et al. 2022

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Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. It can cause fatty liver (steatosis), steatohepatitis, fibrosis, cirrhosis, and liver cancer. Alcohol consumption can also disturb the composition of gut microbiota, increasing the composition of harmful microbes and decreasing beneficial ones. Restoring eubiosis or preventing dysbiosis after alcohol consumption is an important strategy in treating ALD. Plant natural products and polyphenolic compounds exert beneficial effects on several metabolic disorders associated with ALD. Natural products and related phytochemicals act through multiple pathways, such as modulating gut microbiota, improving redox stress, and anti-inflammation. In the present review article, we gather information on natural extract and bioactive compounds on the gut-liver axis for the possible treatment of ALD. Supplementation with natural extracts and bioactive compounds promoted the intestinal tight junction, protected against the alcohol-induced gut leakiness and inflammation, and reduced endotoxemia in alcohol-exposed animals. Taken together, natural extracts and bioactive compounds have strong potential against ALD; however, further clinical studies are still needed.

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Section: Discussionmentioning

confidence: 99%

“…Oral administration of oyster ( Crassostrea gigas ) polysaccharides (282 mg/kg bw) could also increase the proportion of Roseburia spp. and Lactobacillus reuteri , and decrease Escherichia proportion in ALD mice [ 78 ].…”

Section: Protective Effect Of Natural Products and Their Bioactive Co...mentioning

confidence: 99%

The Beneficial Effects of Natural Extracts and Bioactive Compounds on the Gut-Liver Axis: A Promising Intervention for Alcoholic Liver Disease

et al. 2022

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“…After transport to the liver, it can inhibit PPARγ and SREBP-1c expression and activity, regulate lipid metabolism disorders by inducing SREBP-1c transcription factor, alleviate excessive hepatic lipid deposition, and regulate intrahepatic lipid metabolism ( 43 ). Similarly, oyster polysaccharides were found to help restore the intestinal barrier, reduce the levels of the pro-inflammatory markers, and decrease lipid accumulation by activating the AMPKα/SREBP1c pathway and enriching SCFAs ( 45 ). A study has reported that the aqueous extract of the blue mussel, Mytilus edulis, shows anti-adipogenic activity and inhibits lipid accumulation by suppressing the expression of the mRNA levels of the adipogenic genes ( 46 ).…”

Section: Biological Activity Of Shellfish Polysaccharidesmentioning

confidence: 99%

“…Restructuring of the gut microbiome and an elevation in SCFAs levels, which are essential for the prevention of alcohol-induced steatohepatitis, were found in the RPS- and SPS-treated groups. The oyster polysaccharides could also help restore the intestinal barrier, reduce inflammation, and decrease lipid accumulation by activating the AMPKα/SREBP1c pathway and enriching SCFAs ( 45 ). After polysaccharide treatment, the TG levels in liver tissues were found to decrease by 17.88 and 15.69% in the RPS and SPS groups, respectively.…”

Section: Biological Activity Of Shellfish Polysaccharidesmentioning

confidence: 99%

“…Treatment with oyster polysaccharides significantly increased propionate levels and enhanced the production of propionic and butyric acid microorganisms ( Lactobacillus reuteri , Bifidobacterium longum , and Roseburia spp.) ( 45 ). Butyrate affected the expression of genes involved in the regulation of lipid/glucose metabolism ( 102 ).…”

Section: Biological Activity Of Shellfish Polysaccharidesmentioning

confidence: 99%

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A review on shellfish polysaccharides: Extraction, characterization and amelioration of metabolic syndrome

et al. 2022

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Shellfish are diverse, widely distributed organisms that are a rich source of biological resources. Polysaccharides are an important components in shellfish, hence a great deal of attention has been directed at isolation and characterization of shellfish polysaccharides because of their numerous health benefits. Differences in shellfish species, habits, and environment result in the diversity of the structure and composition of polysaccharides. Thus, shellfish polysaccharides possess special biological activities. Studies have shown that shellfish polysaccharides exert biological activities, including antioxidant, antitumor, immune-regulation, hypolipidemic, antihypertensive, and antihyperglycemic effects, and are widely used in cosmetics, health products, and medicine. This review spotlights the extraction and purification methods of shellfish polysaccharides and analyses their structures, biological activities and conformational relationships; discusses the regulatory mechanism of shellfish polysaccharides on hyperlipidemia, hypertension, and hyperglycemia caused by lipid metabolism disorders; and summarizes its alleviation of lipid metabolism-related diseases. This review provides a reference for the in-depth development and utilization of shellfish polysaccharides as a functional food to regulate lipid metabolism-related diseases. To achieve high value utilization of marine shellfish resources while actively promoting the development of marine biological industry and health industry.

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Probiotic‐fermented Pueraria lobata (Willd.) Ohwi alleviates alcoholic liver injury by enhancing antioxidant defense and modulating gut microbiota

Zhao

Peng

et al. 2022

J Sci Food Agric

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BACKGROUND: Pueraria lobata (Willd.) Ohwi (PL) has been used in China to detoxify alcohol and protect the liver for millennia, though its mechanism of liver protection has not been elucidated. However, fermentation is considered to be one of the effective ways to enhance the efficacy of traditional Chinese medicine. The aim of this study was to investigate the hepatoprotective mechanism of probiotic-fermented PL (FPL). Sprague Dawley rats were administered with FPL followed by gavage of alcohol for seven consecutive days; following that, liver injury levels were evaluated in rats.RESULTS: FPL ameliorated lipid accumulation and inflammation levels in rats. Meanwhile, the levels of ethanol dehydrogenase, acetaldehyde dehydrogenase, and cytochrome P4502E1 were elevated by FPL treatment. It was observed that the levels of catalase, superoxide dismutase, and glutathione peroxidase were elevated, and the expression of nuclear transcriptional factor (erythroid-derived 2)-like 2 (Nrf2) and heme oxygenase-1 genes and proteins were increased by FPL treatment, demonstrating that the Nrf2-mediated signal pathway was activated. Furthermore, FPL restored the composition of the gut microbiota with an increase in the abundances of Firmicutes and Lactobacillus and a decrease in the abundances of Bacteroidota and Akkermansia. Additionally, a strong correlation was found between the gut microbiota and the antioxidant parameters. CONCLUSION:The results indicate that FPL possesses an excellent protective effect in alcoholic liver injury. Our findings are beneficial to the development of hepatoprotective nutraceuticals for alcoholics.

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Mediation of the microbiome-gut axis by oyster (Crassostrea gigas) polysaccharides: A possible protective role in alcoholic liver injury

Cited by 35 publications

References 34 publications

The Beneficial Effects of Natural Extracts and Bioactive Compounds on the Gut-Liver Axis: A Promising Intervention for Alcoholic Liver Disease

The Beneficial Effects of Natural Extracts and Bioactive Compounds on the Gut-Liver Axis: A Promising Intervention for Alcoholic Liver Disease

A review on shellfish polysaccharides: Extraction, characterization and amelioration of metabolic syndrome

Probiotic‐fermented Pueraria lobata (Willd.) Ohwi alleviates alcoholic liver injury by enhancing antioxidant defense and modulating gut microbiota

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