Objective. To investigate the related factors of skin damage caused by peripherally inserted central catheter (PICC) in cancer patients. Methods. It was a retrospective analysis of 202 cancer patients admitted to our hospital from February 2014 to July 2019. 50 cases of PICC-related skin damage and 152 cases of non-skin damage were studied. In addition, multivariate logistic regression analysis was used to determine independent risk factors for PICC-related skin damage, including cancer patients with catheter-related skin damage and patients without skin damage. Results. 50 patients with PICC skin damage (19 males and 31 females) and 152 patients without skin damage (62 males and 90 females) were retrospectively analyzed. The skin damage rate was 24.8%. The analysis of variance results showed that many factors are related to PICC catheter-related skin damage, including hormones (χ2/Z = 4.468,
P
<
0.05
), body mass index (BMI) (χ2/Z = −2.443,
P
<
0.05
), days with tube (χ2 = 26.230,
P
<
0.05
), chemotherapy cycle (χ2/Z = 25.638,
P
<
0.05
), and self-care ability (χ2/Z = −1.968,
P
<
0.05
). Logistic regression analysis showed that hormones (odds ratio (OR) = 3.896,
P
=
0.045
), BMI (OR = 1.129,
P
=
0.017
), days with tube (OR = 0.419,
P
=
0.013
), and chemotherapy cycle (OR = 3.302,
P
=
0.028
) are independent factors affecting PICC-related skin damage. Conclusion. The independent influencing factors of skin damage during PICC catheterization are hormones, BMI, number of days with tube, and chemotherapy cycle.