Medical foods in Alzheimer’s disease

Lange, Klaus W.; Guo, Jianjun; Kanaya, Shigehiko; Lange, Katharina; Nakamura, Yukiko; Li, Shiming

doi:10.1016/j.fshw.2019.02.002

Cited by 25 publications

(13 citation statements)

References 74 publications

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“…Effective alternate approaches to AD drug development are critically needed as most of all clinical drug immunotherapy trials have failed to date ( Anderson et al, 2017 ; Mehta et al, 2017 ). Thus, food-derived compounds warrant investigation being potential therapeutic agents ( Thaipisuttikul and Galvin, 2012 ; Lange et al, 2019 ; Peng et al, 2021 ). These emerging alternative strategies using natural compounds hold promise for early intervention by targeting the prodromal phase of the disease ( Lange et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

A Synergistic Combination of DHA, Luteolin, and Urolithin A Against Alzheimer’s Disease

Jayatunga

Hone

Fernando

et al. 2022

Front. Aging Neurosci.

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Alzheimer’s disease (AD) is a devastating neurodegenerative disorder and the most common form of dementia worldwide. The classical AD brain is characterized by extracellular deposition of amyloid-β (Aβ) protein aggregates as senile plaques and intracellular neurofibrillary tangles (NFTs), composed of hyper-phosphorylated forms of the microtubule-associated protein Tau. There has been limited success in clinical trials for some proposed therapies for AD, so attention has been drawn toward using alternative approaches, including prevention strategies. As a result, nutraceuticals have become attractive compounds for their potential neuroprotective capabilities. The objective of the present study was to derive a synergistic nutraceutical combination in vitro that may act as a potential preventative therapy for AD. The compounds of interest were docosahexaenoic acid (DHA), luteolin (LUT), and urolithin A (UA). The cell viability and cytotoxicity assays MTS and LDH were used to evaluate the compounds individually and in two-compound combinations, for their ability to inhibit Aβ1–42-induced toxicity in human neuroblastoma BE(2)-M17 cells. The LDH-derived% protection values were used in the program CompuSyn v.1.0 to calculate the combination index (CI) of the two-compound combinations. The software-predicted potentially synergistic (CI < 1) two-compound combinations were validated using CellTiter Glo assay. Finally, a three-compound combination was predicted (D5L5U5) and shown to be the most effective at inhibiting Aβ1–42-induced toxicity. The synergistic combination, D5L5U5 warrants further research for its mechanism of action; however, it can serve as a basis to develop an advanced functional food for the prevention or co-treatment of AD.

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Section: Discussionmentioning

confidence: 99%

A Synergistic Combination of DHA, Luteolin, and Urolithin A Against Alzheimer’s Disease

Jayatunga

Hone

Fernando

et al. 2022

Front. Aging Neurosci.

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“…Ten years ago, the magazine Time dedicated the cover and a service about this theme, by using a significant title: Why Your DNA Isn't Your Destiny [324]. The message is extremely modern: DNA is not our destiny, so you can do something to change your destiny.…”

Section: Bioactive Compound Actions On Epigenetic Mechanisms In Alzhementioning

confidence: 99%

Functional Foods: An Approach to Modulate Molecular Mechanisms of Alzheimer’s Disease

Atlante

Amadoro

Bobba

et al. 2020

Cells

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A new epoch is emerging with intense research on nutraceuticals, i.e., “food or food product that provides medical or health benefits including the prevention and treatment of diseases”, such as Alzheimer’s disease. Nutraceuticals act at different biochemical and metabolic levels and much evidence shows their neuroprotective effects; in particular, they are able to provide protection against mitochondrial damage, oxidative stress, toxicity of β-amyloid and Tau and cell death. They have been shown to influence the composition of the intestinal microbiota significantly contributing to the discovery that differential microorganisms composition is associated with the formation and aggregation of cerebral toxic proteins. Further, the routes of interaction between epigenetic mechanisms and the microbiota–gut–brain axis have been elucidated, thus establishing a modulatory role of diet-induced epigenetic changes of gut microbiota in shaping the brain. This review examines recent scientific literature addressing the beneficial effects of some natural products for which mechanistic evidence to prevent or slowdown AD are available. Even if the road is still long, the results are already exceptional.

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“…The PREDIMEM study “Prevention with the Mediterranean Diet” found that a bigger adherence to MD was inversely associated with the incidence of type 2 diabetes, which was reduced by 52% in the MD group compared to the control group [ 55 ]. In relation to neurodegenerative diseases, a high adherence to MD has been associated with improved cognitive function and lower risk of dementia [ 56 , 57 , 58 , 59 ]. However, many of these studies are observational, and can therefore not display a cause–effect relation.…”

Section: The Influence Of Nutrition On the Microbiota And Agingmentioning

confidence: 99%

Relationship between Diet, Microbiota, and Healthy Aging

et al. 2020

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Due to medical advances and lifestyle changes, population life expectancy has increased. For this reason, it is important to achieve healthy aging by reducing the risk factors causing damage and pathologies associated with age. Through nutrition, one of the pillars of health, we are able to modify these factors through modulation of the intestinal microbiota. The Mediterranean and Oriental diets are proof of this, as well as the components present in them, such as fiber and polyphenols. These generate beneficial effects on the body thanks, in part, to their interaction with intestinal bacteria. Likewise, the low consumption of products with high fat content favors the state of the microbiota, contributing to the maintenance of good health.

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Medical foods in Alzheimer’s disease

Cited by 25 publications

References 74 publications

A Synergistic Combination of DHA, Luteolin, and Urolithin A Against Alzheimer’s Disease

A Synergistic Combination of DHA, Luteolin, and Urolithin A Against Alzheimer’s Disease

Functional Foods: An Approach to Modulate Molecular Mechanisms of Alzheimer’s Disease

Relationship between Diet, Microbiota, and Healthy Aging

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