Medical isotope development and supply opportunities in the 21st century

Troyer, G.L.; Schenter, R.E.

doi:10.1007/s10967-009-0267-4

Cited by 9 publications

(7 citation statements)

References 6 publications

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“…This type of isotopes decay with + and/or EC accompanied with specific gamma rays and can be used for Positron Emission Tomography (PET) such as 11 C, 15 O, 13 N, and 18 F or SPECT such as 111 I, 67 Ga and 201 Tl (Lamberecht, 1979;Qaim, 2001). A number of isotopes as shown in Table 1 are technically available for use in medical applications (Troyer & Schenter, 2009 Table 1. Common medical isotopes sorted by use category and production method (Troyer & Schenter, 2009) 1.3 Molybdenum and technetium in nuclear medicine M o l y b d e n u m i s u s e d a s a t a r g e t m a t e r i a l f o r t h e p r o d u c t i o n o f m e d i c a l l y i m p o r t a n t radioisotopes, such as 99m Tc/ 99 Mo, 96(m+g) Tc and 94m Tc.…”

Section: Medical Radioisotopes Productionmentioning

confidence: 99%

“…A number of isotopes as shown in Table 1 are technically available for use in medical applications (Troyer & Schenter, 2009 Table 1. Common medical isotopes sorted by use category and production method (Troyer & Schenter, 2009) 1.3 Molybdenum and technetium in nuclear medicine M o l y b d e n u m i s u s e d a s a t a r g e t m a t e r i a l f o r t h e p r o d u c t i o n o f m e d i c a l l y i m p o r t a n t radioisotopes, such as 99m Tc/ 99 Mo, 96(m+g) Tc and 94m Tc. 94m Tc (52min), has shown its applicability as a PET isotope (Rösch and Qaim, 1993;Nickles, et al, 1993;Sajjad and Lambrecht, 1993;Rösch, et al, 1994;Fabbender, et al, 1994;Qaim, 2000;Hohn, et al, 2008 (Lambrecht and Montner, 1982).…”

Section: Medical Radioisotopes Productionmentioning

confidence: 99%

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Medical Radioisotopes Production: A Comprehensive Cross-Section Study for the Production of Mo and Tc Radioisotopes Via Proton Induced Nuclear Reactions on natMo

Alharbi¹,

Azzam²,

McCleskey³

et al. 2011

Radioisotopes - Applications in Bio-Medical Science

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Section: Medical Radioisotopes Productionmentioning

confidence: 99%

Section: Medical Radioisotopes Productionmentioning

confidence: 99%

Medical Radioisotopes Production: A Comprehensive Cross-Section Study for the Production of Mo and Tc Radioisotopes Via Proton Induced Nuclear Reactions on natMo

Alharbi¹,

Azzam²,

McCleskey³

et al. 2011

Radioisotopes - Applications in Bio-Medical Science

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“…Some isotopic productions benefit from thermal (low energy) neutrons and others from higher energy ( Table 2). Table 2 Neutron Energy Ranges needed to produce several medical isotopes (19).…”

Section: Nuclear Reactor Produced Radioisotopesmentioning

confidence: 99%

“…After the preparation of the microspheres, the DOTA decoration reaction was performed (Fig 58). (total mass of 100,000 particles, 63 ng/particle) present in each preparation accounts for 2.33·10 19 available NH 2 groups in total. However, only a fraction of these groups are exposed to the microsphere surface and to further complicate the problem, the surface is not perfectly flat (Fig 63 A).…”

Section: Particle Preparation and Surface Modificationmentioning

confidence: 99%

“…vii Table 2 Neutron Energy Ranges needed to produce several medical isotopes (19). 13 Table 3 Positronic radionuclides production vs. incident proton energy 15 Table 4 Some Parent/Daughter couples with transient and secular equilibrium 18 Table 5 Some commercially available radioisotopic generators for medical use 20 Table 6 Available 68 Ge/ 68 Ga Generator Systems 21 ANNEX 2 A: Table 7 Experimental organ-by-organ emission distributions 129 ANNEX 2 B: Table 8 Re-casted distributions for the MCNPX ROBY model 131 ANNEX 3: Table 9 Tc generator and B: the 68 Ge/ 68 Ga generator.…”

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confidence: 99%

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Microspheres for Liver Radiomicrospheres Therapy and Planning

Amor‐Coarasa¹

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DEDICATIONTo my grandfather, my guide in life, who taught me early that a kick in the a** is also a push forward and that I should never give up.To Prof. José Griffith Martínez, the first Cuban Radiochemist, my friend and mentor, who passed away alone and forgotten on December 8, 2008.To Prof. Simón Rodríguez Calvo, the best teacher I ever had.iv ACKNOWLEDGMENTS I want to express my infinite gratitude to my advisor Dr. Anthony McGoron. His door was always opened and no matter how hard the words were, he would lay then down like lead bricks on my chest and that's the kind of honesty I really appreciate. To Dr. Seza Gulec, mentor, friend and older brother, our reasoning alignment was sometimes disturbing and creepy. We could just look at each other without needing words to communicate. Both (Dr. McGoron and Dr. Gulec) embraced my abilities and trusted my knowledge when I first came to this country, they will be therefore somehow responsible for all my future achievements and for that I am grateful. To Dr.James Byrne, a walking encyclopedia, he was always willing to help. I really enjoyed all of our conversations no matter what the topic was. To Manuel Sztejnberg for all the help provided. Table 2 Neutron Energy Ranges needed to produce several medical isotopes (19). 13 Table 3 Positronic radionuclides production vs. incident proton energy 15 Table 4 Some Parent/Daughter couples with transient and secular equilibrium 18 Table 5 Some commercially available radioisotopic generators for medical use 20 patients showed that combining SirSpheres (one of the available products in the market) with chemotherapy had a 44 % response versus a 17.6 % with chemotherapy alone (3).The 90 Y disintegration within glass microspheres occurs without any chemical release because the radioisotope is completely trapped inside the microsphere and is part of the crystalline structure. 2In other words, there is no surface degradation of the particles. Resin microspheres are basically ionic exchange matrices that bind the yttrium by means of strong non-specific ionic interactions.The earliest device of this kind (resin microspheres) was shown to release the isotope once in contact with blood (4) and also showed some other complications (5; 6). Although there is no report of leaching of 90 Y for the commercial SirSpheres product, such behavior is a possibility, even if not significant, because of the ionic nature of the radioisotope attachment to the particles.SirSpheres are prescribed to be injected using pure water instead of saline solution to avoid any ionic exchange before injection. The main advantage of the resin spheres is that the radiation dose and concentration of spheres can be manipulated in situ to provide a patient specific treatment. In contrast the glass spheres need to be allowed to decay in order to achieve the proper dose.The possibility of injury to gastrointestinal tract and lungs are complications that can be evaluated (predicted), to a certain extent, using a hepatic arterial flow imaging study with Tc-MAA is inf...

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Producing radioisotopes in power reactors

Ahmad

2011

J Radioanal Nucl Chem

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Medical isotope development and supply opportunities in the 21st century

Cited by 9 publications

References 6 publications

Medical Radioisotopes Production: A Comprehensive Cross-Section Study for the Production of Mo and Tc Radioisotopes Via Proton Induced Nuclear Reactions on natMo

Medical Radioisotopes Production: A Comprehensive Cross-Section Study for the Production of Mo and Tc Radioisotopes Via Proton Induced Nuclear Reactions on natMo

Microspheres for Liver Radiomicrospheres Therapy and Planning

Producing radioisotopes in power reactors

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