Medical vagotomy: New evidence of its potential usefulness as a preoperative test

Meperidine is a potent narcotic related chemically and pharmacologically to morphine and atropine. To examine its gastric antisecretory activity a study designed to test the effect of meperidine on basal acid secretion was carried out: 100 mg of meperidine given intramuscularly reduced basal acid output (BAO) by 66.3% at 1 hr (P less than 0.001), 64.9% at 2 hr (P less than 0.001), and 44.9% at 3 hr (P = 0.005). This degree of reduction of BAO by this dose of meperidine did not differ from that produced by 30 mg of propantheline intramuscularly. These results demonstrate that meperidine in standard classical doses is a potent inhibitor of BAO in man.

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Potent reduction of basal acid output produced by meperidine

Meeroff

Fernandez

Gaon

1978

Digest Dis Sci

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Inhibition of Basal and Pentagastrin-stimulated Gastric Acid Secretion after Treatment with Benzilonium Bromide and after Selective Proximal Vagotomy

Jaska¹

1977

Scandinavian Journal of Gastroenterology

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50 consecutive patients with radiographically verified duodenal ulcer and a history of peptic ulcer disease for more than 3 years and with elevated gastric acid secretion in the basal state and after stimulation with pentagastrin were randomly allocated to two groups. The first group of 25 patients was treated with benzilonium bromide (Ulcoban Prolongatum, Parke, Davis & Co.) and the second group was subjected to selective proximal vagotomy (SPV). The patient's gastric acid secretion was determined before the start of treatment and after 1, 6, and 12 months. After one year the basal acid output had decreased by 58.2% in the group treated with benzilonium bromide and by 82.9% in the patients who had undergone SPV. The peak acid output fell by 49.4% in the benzilonium group and by 66.1% in the SPV group.

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Ranitidine versus Anticholinergic/Antacid for Duodenal Ulcer

Miettinen

Anttonen

Aukee

et al. 1985

Scandinavian Journal of Gastroenterology

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One hundred and forty-nine patients with endoscopically documented duodenal or prepyloric ulcer were randomly allocated to treatment with ranitidine, 150 mg twice daily (75 patients), or glycopyrrobromide, 2 mg three times daily, and antacid suspension, 60 ml/day, with a buffering capacity of 480 mmol/day (74 patients). The patients underwent a thorough prestudy symptom analysis, and endoscopy was performed by an observer who was unaware of the treatment in use. After 4- and 8-week courses of treatment the patients were re-evaluated. Sixty-nine patients in the ranitidine group and 66 in the anticholinergic/antacid group completed the trial. Complete ulcer healing was obtained in 60 of the 69 patients (87%) in the ranitidine group and in 50 of the 66 patients (76%) in the anticholinergic/antacid group after 4 weeks of treatment and in 65 (94%) and in 61 (92%), respectively, after 8 weeks of treatment. Forty-three patients had troublesome side effects of either anticholinergic or antacid treatment, and three patients had to interrupt the treatment. There were no serious side effects of ranitidine. This study suggests that ranitidine causes faster ulcer healing than the combination of anticholinergic and antacid. The results show that ranitidine is an effective and safe drug for duodenal ulcer healing, with no troublesome side effects.

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Medical vagotomy: New evidence of its potential usefulness as a preoperative test

Cited by 4 publications

References 14 publications

Potent reduction of basal acid output produced by meperidine

Potent reduction of basal acid output produced by meperidine

Inhibition of Basal and Pentagastrin-stimulated Gastric Acid Secretion after Treatment with Benzilonium Bromide and after Selective Proximal Vagotomy

Ranitidine versus Anticholinergic/Antacid for Duodenal Ulcer

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