Medication management and treatment adherence in Parkinson's disease patients with mild cognitive impairment

Şekerci, Betül Sümbül; Hanağası, Haşmet; Bılgıç, Başar; Tüfekçıoğlu, Zeynep; Gürvit, Hakan; Emre, Murat

doi:10.1007/s13760-022-01916-1

Cited by 5 publications

(1 citation statement)

References 45 publications

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“…For example, patients with cognitive impairment often exhibit poorer medication management and treatment adherence compared to cognitively normal patients. This discrepancy leads to greater fluctuations in blood pressure among patients with PD who also have hypertension (Sumbul‐Sekerci et al., 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Association between the blood pressure variability and cognitive decline in Parkinson's disease

Xiao,

Yang,

Zhang

et al. 2023

Brain and Behavior

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ObjectivesHigh visit‐to‐visit blood pressure variability (BPV) was found to be associated with cognitive decline in the elderly. This study aimed to investigate the impact of visit‐to‐visit BPV on cognition in patients with early‐stage Parkinson's disease (PD).DesignThis is a retrospective analysis of a prospective cohort.Setting and participantsA total of 297 patients with early‐stage PD (103 mild cognitive impairments [PD‐MCI] and 194 normal cognitions [PD‐NC] at baseline) were included from the Parkinson's Progression Markers Initiative study.MethodsVariation independent of mean (VIM) of the first year was used as the indicator of BPV. The Montreal Cognitive Assessment (MoCA) was used to assess global cognition. Patients were divided into PD‐MCI and PD‐NC according to the MoCA score at baseline. Longitudinal cerebrospinal fluid (Aβ‐42, Aβ, α‐synuclein, neurofilament light protein, tau phosphorylated at the threonine 181 position, total tau, glial fibrillary acidic protein) and serum (neurofilament light protein) biomarkers were assessed. The Bayesian linear growth model was used to evaluate the relationship between baseline BPV and the rate of change in cognition and biomarkers.ResultsHigher systolic VIM of the first year was related to a greater rate of decline in MoCA score in the following years in PD‐MCI (β = −.15 [95% CI −.29, −.01]). No association was found between BPV and biomarkers.Conclusion and implicationsHigher systolic VIM predicted a steeper decline in cognitive tests in PD‐MCI independently from the mean value of blood pressure, orthostatic hypotension, and supine hypertension.

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Section: Discussionmentioning

confidence: 99%

Association between the blood pressure variability and cognitive decline in Parkinson's disease

Xiao,

Yang,

Zhang

et al. 2023

Brain and Behavior

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Causality between cognitive performance and cardiovascular disease: A bidirectional Mendelian randomization study

Duan,

Xiao,

Liu

et al. 2024

Gene

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The association between cognitive performance and meniscal injuries: A Mendelian randomization analysis

Li,

Yin,

Zhou

et al. 2024

Preprint

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Background The causal relationship between cognitive performance and meniscal injuries is unclear. This study aims to elucidate the genetic causality between cognitive performance and meniscal injuries. Methods We conducted a two-sample Mendelian Randomization (MR) analysis utilizing summary-level data from extensive genome-wide association studies. Single nucleotide polymorphisms (SNPs) achieving genome-wide significance (P < 5*10− 8) were employed as instrumental variables for each exposure. The inverse-variance weighted (IVW) method served as the principal statistical technique, complemented by the weighted median, MR-Egger regression, and MR-PRESSO methods for sensitivity analyses, accommodating some of the assumptions inherent in IVs. Results Genetically predicted cognitive performance was inversely correlated with the odds of meniscal injuries. However, the MR-Egger regression analysis did not corroborate this association. The inverse-variance weighting (IVW) method yielded a pooled odds ratio(OR) of 0.76 (95% CI 0.66–0.88; P = 2*10− 4) per standard deviation increase in the prevalence of cognitive performance, a finding echoed by the weighted median method(OR:0.81, 95% CI 0.67–0.98; P = 3*10− 2).Additionally, we did not detect pleiotropy of effects in our investigation using the MR-Egger intercept and Cochran’s Q test(P > 0.05). But there is heterogeneity between them (P > 0.05). Conclusion This study used MR analysis to analyze and explore the genetic data, which showed that cognitive decline is a risk factor for meniscal injuries, and further studies on the mechanisms of the role between the two are needed in the future.

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Medication management and treatment adherence in Parkinson's disease patients with mild cognitive impairment

Cited by 5 publications

References 45 publications

Association between the blood pressure variability and cognitive decline in Parkinson's disease

Association between the blood pressure variability and cognitive decline in Parkinson's disease

Causality between cognitive performance and cardiovascular disease: A bidirectional Mendelian randomization study

The association between cognitive performance and meniscal injuries: A Mendelian randomization analysis

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