Medicinal properties of mangosteen (Garcinia mangostana)

Pedraza‐Chaverrí, José; Cárdenas-Rodríguez, Noemi; Orozco-Ibarra, Marisol; Pérez‐Rojas, Jazmin M.

doi:10.1016/j.fct.2008.07.024

Cited by 633 publications

(473 citation statements)

References 91 publications

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“…them such as α-mangostin, 8-desoxygartanin and 3-isomangostin are found in mangosteen [1]. The chemical structures of 8 major xanthones contained in pericarps are shown in Figure 1.…”

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confidence: 99%

Extraction of Xanthones from the Pericarps of <i>Garcinia mangostana</i> Linn. with Supercritical Carbon Dioxide and Ethanol

Mishima

Kawakami

Yokota

et al. 2013

SERDJ

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The extraction of xanthones, such as α-mangostin from the pericarp of mangosteen (Garcinia mangostana Linn.) by supercritical fluid extraction (SFE), for which the solvent was carbon dioxide (CO 2 ), was carried out at 35, 40 and 50 ºC. The extraction pressure was from 10 to 20 MPa. In order to enhance the yield of the extraction, ethanol was added as an entrainer. The yields of xanthones, such as α-mangostin in the extraction were significantly improved, whereas a change in the selectivity of the extract was not observed. We also conducted qualitative and quantitative analyses for xanthones in the extract by HPLC, and analyzed the extraction behavior. The effect of three operating parameters, such as temperature, pressure and the mole fraction of ethanol in a supercritical solution of CO 2 on the extraction yield was investigated using the single-factor method.

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“…them such as α-mangostin, 8-desoxygartanin and 3-isomangostin are found in mangosteen [1]. The chemical structures of 8 major xanthones contained in pericarps are shown in Figure 1.…”

mentioning

confidence: 99%

Extraction of Xanthones from the Pericarps of <i>Garcinia mangostana</i> Linn. with Supercritical Carbon Dioxide and Ethanol

Mishima

Kawakami

Yokota

et al. 2013

SERDJ

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“…Mangosteen pericarp and the whole fruits have been used for centuries in Southeast Asia to treat several diseases such as diarrhea, dysentery, infections of the skin, inflammation, and fever. 8,9) This tree contains a large amount of tricyclic isoprenylated polyphenols, referred to as xanthones, and the fruits have putative medicinal effects. In general, xanthones are found in a small group of higher plants, with at least 68 distinct xanthones identified in the mangosteen plant alone.…”

Section: -7)mentioning

confidence: 99%

Alpha-mangostin promotes myoblast differentiation by modulating the gene-expression profile in C2C12 cells

Horiba

Katsukawa

Abe

et al. 2014

Bioscience, Biotechnology, and Biochemistry

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Alpha-mangostin, a xanthone contained mostly in mangosteen pericarp, has been reported to exert various biological functions. However, little is known about involvement of this xanthone in the muscle differentiation process. Here, we report the effect of α-mangostin on murine skeletal muscle-derived C2C12 myoblasts. α-mangostin stimulated myoblast differentiation leading to myotube formation. DNA microarray analysis revealed that genes associated with myoblast differentiation and muscle cell component formation were up-regulated in α-mangostin-treated cells. These results indicate that α-mangostin promotes myoblast differentiation through modulating the gene-expression profile in myoblasts.

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“…α-mangostin was the first xanthone isolated from G. mangostana and several other xanthones were isolated as well (Pedraza-Chaverri et al, 2008). Previous studies on different xanthones demonstrated remarkable pharmacological activities including analgesic (Cui et al, 2010), antioxidant (Jung et al, 2006), antiinflammatory Tewtrakul et al, 2009), anticancer (Akao et al, 2008;Doi et al, 2009;Hung et al, 2009;Matsumoto et al, 2004), antiallergy (Nakatani et al, 2002), antibacterial (Chomnawang et al, 2009;Sakagami et al, 2005), antituberculosis (Suksamrarn et al, 2003), antifungal (Kaomongkolgit et al, 2009) and antiviral (Chen et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Antitumorigenicity of xanthones-rich extract from Garcinia mangostana fruit rinds on HCT 116 human colorectal carcinoma cells

Aisha¹,

Abu‐Salah²,

Nassar³

et al. 2011

Rev. bras. farmacogn.

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This study aimed to investigate the antitumorigenicity of xanthones-rich extract from Garcinia mangostana L., Clusiaceae, fruit rinds which was obtained by a simple recrystallization of 75% ethanolic extract. α-Mangostin content of the extract was determined qualitatively by TLC and quantitatively by HPLC, and total xanthones content was quantified by UV spectrophotometry. The extract was evaluated for cytotoxicity, apoptosis and antitumorigenicity on HCT 116 human colorectal carcinoma cells. α-Mangostin was found to be the main constituent of the extract which was 71.2±0.1%, and the total xanthones content was 95±4.8% (wt/ wt). The extract showed potent dose dependent cytotoxicity with IC50 value 9.2 µg/ mL. Apoptosis studies revealed activation of caspases 3 and 7, DNA fragmentation, chromatin condensation and loss of mitochondrial membrane potential. Studies on cell migration and colony formation indicate reduced cell migration ability and clonogenicity of treated HCT 116 cells at sub-inhibitory concentrations. Taken together, the cytotoxic effect of the xanthones extract is mediated through the mitochondrial pathway of apoptosis. The reduced cell migration and clonogenicity of HCT 116 cells might prevent both primary and metastatic tumor growth in vivo which will be the topic of our future work using the metastatic orthotopic colon cancer model.

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Medicinal properties of mangosteen (Garcinia mangostana)

Cited by 633 publications

References 91 publications

Extraction of Xanthones from the Pericarps of <i>Garcinia mangostana</i> Linn. with Supercritical Carbon Dioxide and Ethanol

Extraction of Xanthones from the Pericarps of <i>Garcinia mangostana</i> Linn. with Supercritical Carbon Dioxide and Ethanol

Alpha-mangostin promotes myoblast differentiation by modulating the gene-expression profile in C2C12 cells

Antitumorigenicity of xanthones-rich extract from Garcinia mangostana fruit rinds on HCT 116 human colorectal carcinoma cells

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