Mediterranean Diet and Soy Isoflavones for Integrated Management of the Menopausal Metabolic Syndrome

Marini, Herbert

doi:10.3390/nu14081550

Cited by 31 publications

(28 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although limited to female participants, the estrogenic effects of isoflavones such as genistein may also have an effect. Genistein is known to reduce various risks, especially in postmenopausal females [ 58 , 59 , 60 ]. It is assumed that such risk reduction and improvement in quality of life may also affect mental stress.…”

Section: Discussionmentioning

confidence: 99%

Effect of Oral Administration of Lactiplantibacillus plantarum SNK12 on Temporary Stress in Adults: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Study

Watanabe

Hayashi

Takara

et al. 2022

IJERPH

View full text Add to dashboard Cite

Mouse studies have reported anti-stress effects of Lactiplantibacillus plantarum SNK12 (SNK). Specifically, oral SNK administration increased mRNA levels of hippocampal neurotrophic factor and gamma-aminobutyric acid receptor in mice with sub-chronic mild stress-induced social defeat; moreover, it improved depressive behavior. We aimed to evaluate the efficacy of SNK ingestion against stress in healthy adults. We used the Uchida–Kraepelin test for the stress load, with a low-dose (50 mg/day), high-dose (150 mg/day), and placebo groups (dextrin). The primary outcome was the psychological evaluation as measured by the Profile of Mood States 2nd Edition (POMS2) using total mood disturbance (TMD) scores. The secondary outcomes were the score of each POMS2 item, salivary cortisol as a stress marker, and autonomic balance with the low frequency (LF)/ high frequency (HF) ratio. Compared with the placebo group, the SNK ingestion group showed significantly lower TMD scores. Additionally, compared with the placebo group, the high-dose group showed significantly lower scores for Tension-Anxiety and Confusion-Bewilderment, while the low-dose group showed significantly lower Anger-Hostility scores, salivary cortisol levels, and LF/HF scores. Our findings suggest that SNK ingestion could relieve stress (negative feelings, anxiety, tension, embarrassment, confusion, anger, and hostility) resulting from the temporary load caused by work and study.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Oral Administration of Lactiplantibacillus plantarum SNK12 on Temporary Stress in Adults: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Study

Watanabe

Hayashi

Takara

et al. 2022

IJERPH

View full text Add to dashboard Cite

show abstract

“… 19 A clinical trial showed that genistein, which is the most abundant and active isoflavone in soy, acting as a natural selective ER-modulator, can improve surrogate endpoints associated with risk for diabetes and CVD in postmenopausal women with metabolic syndrome. 19 , 20 Most of the individuals with IFG studied by us were women of menopausal age, therefore, when planning further studies on the dietary prevention of T2D, it is advisable to study the effect of not only the use of dietary fibers, but also isoflavones. It is possible that the addition of soy products, such as tofu, may counteract the possible hormonal effects of dietary fiber.…”

Section: Discussionmentioning

confidence: 99%

Metabolic and Anthropometric Parameters of Persons at Risk of Developing Type 2 Diabetes Mellitus Before and After 3 Months of Consuming Insoluble Dietary Fiber

Khalangot

Гуріанов

Zakharchenko

et al. 2022

Nutr Metab Insights

View full text Add to dashboard Cite

Background: Observational studies have shown that insoluble fiber (IF) can be effective in preventing type 2 diabetes (T2D), but there is a lack of experimental data on the effect of short-term consumption of IF on metabolic parameters. We tried to investigate whether there was an improvement in glycemia and body composition in individuals at risk for T2D after 3 months of IF consumption. Methods: This “Type 2 Diabetes Mellitus Prevention Ukraine (T2DPUA)” study describes participants with impaired fasting glucose (IFG) as determined by ADA criteria. The study involved 30 people, including 21 women (70%). Daily, 15 g of IF derived from wheat was used. T2DPUA did not have a placebo group and the intervention lasted 3 months. Evaluation of fasting plasma glucose (FPG) and 2h plasma glucose (2hPG), glycated hemoglobin (HbA1c), total cholesterol, HDL-cholesterol, triacylglycerols, uric acid, and γ-glutamyl transferase was performed. The baseline and 3-monthly anthropometric examinations included measurements of weight, waist and hip circumference. Fat mass was assessed by bioelectrical impedance analysis. Paired samples t-test or Wilcoxon test were used. Result: A decrease of FPG ( P = .042), HbA1c ( P < .001), 2hPG ( P = .005), weight ( P < .001), body mass index ( P < .001), the proportion of body fat ( P = .006), and the absolute amount of fat ( P < .001), increases in systolic ( P < .001) and diastolic ( P = .008) blood pressure was shown. The number of people with hypertension did not change. The absolute amount of body fat decreased by almost 5% and tolerance to the standard glucose load improved by 15%. The dynamics of other metabolic parameters were not revealed. Conclusion and Recommendation: Data about improvement of glycemia and body composition over a short period of using IF by individuals with IFG are new and deserve larger studies.

show abstract

“…The combined effects of lunasin and genistein can also be investigated in terms of diet. The combination of specific diets and bioactive compounds has been discussed to improve health benefits [ 115 ]. Investigating the lunasin chemopreventative and therapeutic effects together with the consumption of diets rich in isoflavones is an interesting alternative.…”

Section: Lunasin Products and Potential Combination Therapeuticsmentioning

confidence: 99%

Lunasin as a Promising Plant-Derived Peptide for Cancer Therapy

Souza

Hernández-Ledesma

Souza

2022

IJMS

View full text Add to dashboard Cite

Cancer has become one of the main public health problems worldwide, demanding the development of new therapeutic agents that can help reduce mortality. Lunasin is a soybean peptide that has emerged as an attractive option because its preventive and therapeutic actions against cancer. In this review, we evaluated available research on lunasin’s structure and mechanism of action, which should be useful for the development of lunasin-based therapeutic products. We described data on its primary, secondary, tertiary, and possible quaternary structure, susceptibility to post-translational modifications, and structural stability. These characteristics are important for understanding drug activity and characterizing lunasin products. We also provided an overview of research on lunasin pharmacokinetics and safety. Studies examining lunasin’s mechanisms of action against cancer were reviewed, highlighting reported activities, and known molecular partners. Finally, we briefly discussed commercially available lunasin products and potential combination therapeutics.

show abstract

Mediterranean Diet and Soy Isoflavones for Integrated Management of the Menopausal Metabolic Syndrome

Abstract: The transition from premenopause to postmenopause is associated with the development of multiple elements of Metabolic Syndrome (MetS) [...]

Cited by 31 publications

References 25 publications

Effect of Oral Administration of Lactiplantibacillus plantarum SNK12 on Temporary Stress in Adults: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Study

Effect of Oral Administration of Lactiplantibacillus plantarum SNK12 on Temporary Stress in Adults: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Study

Metabolic and Anthropometric Parameters of Persons at Risk of Developing Type 2 Diabetes Mellitus Before and After 3 Months of Consuming Insoluble Dietary Fiber

Lunasin as a Promising Plant-Derived Peptide for Cancer Therapy

Contact Info

Product

Resources

About