Medizinische Relevanz von Magnetfeldern zur Schmerztherapie

Salomonowitz, G.; Fortin, Martin; Güntert, Bernhard J.

doi:10.1007/s00482-010-1005-0

Cited by 9 publications

(2 citation statements)

References 35 publications

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“…As a non-invasive, safe and simple therapy, the PEMF therapy is widely used to treat soft injury and bone fracture and relieve pain and inflammation, as well as many other types of diseases and pathologies 35. In the past two decades, researchers have turned their attention to the efficacy of treating OA.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of the pulsed electromagnetic field in osteoarthritis: a meta-analysis

Ding

Lei

et al. 2018

BMJ Open

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ObjectiveTo investigate the efficacy and safety of the pulsed electromagnetic field (PEMF) therapy in treating osteoarthritis (OA).DesignMeta-analysis.Data sourcesPubMed, Embase, the Cochrane Library and Web of Science were searched through 13 October 2017.Eligibility criteria for selecting studiesRandomised controlled trials compared the efficacy of PEMF therapy with sham control in patients with OA.Data extraction and synthesisPain, function, adverse effects and characteristics of participants were extracted. RevMan V.5.2 was used to perform statistical analyses.ResultsTwelve trials were included, among which ten trials involved knee OA, two involved cervical OA and one involved hand OA. The PEMF group showed more significant pain alleviation than the sham group in knee OA (standardised mean differences (SMD)=−0.54, 95% CI −1.04 to –0.04, p=0.03) and hand OA (SMD=−2.85, 95% CI −3.65 to –2.04, p<0.00001), but not in cervical OA. Similarly, comparing with the sham–control treatment, significant function improvement was observed in the PEMF group in both knee and hand OA patients (SMD=−0.34, 95% CI −0.53 to –0.14, p=0.0006, and SMD=−1.49, 95% CI −2.12 to –0.86, p<0.00001, respectively), but not in patients with cervical OA. Sensitivity analyses suggested that the exposure duration <=30 min per session exhibited better effects compared with the exposure duration >30 min per session. Three trials reported adverse events, and the combined results showed that there was no significant difference between PEMF and the sham group.ConclusionsPEMF could alleviate pain and improve physical function for patients with knee and hand OA, but not for patients with cervical OA. Meanwhile, a short PEMF treatment duration (within 30 min) may achieve more favourable efficacy. However, given the limited number of study available in hand and cervical OA, the implication of this conclusion should be cautious for hand and cervical OA.

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of the pulsed electromagnetic field in osteoarthritis: a meta-analysis

Ding

Lei

et al. 2018

BMJ Open

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“…Another advantage is that static magnetic fields have gained considerable popularity as an alternative therapy for pain relief, especially in chronic pain [19, 20], osteoarthritis pain [21, 22], neuropathic pain [23], and postoperative pain [24]. The widespread adaptation is largely due to the perceived efficacy and safety with minimal side-effects [25, 26]. There is a significant body of research [27, 28, 29] on the inhibition of P2X 3 receptors for relieving inflammatory and neuropathic pain.…”

Section: Introductionmentioning

confidence: 99%

3D digital analysis of magnetic force-driven orthodontic tooth movement

Kuwajima

Ishida

Lee

et al. 2019

Heliyon

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With the introduction of rare earth magnets like neodymium-iron-boron (NdFeB), it has become possible to produce small magnets with high forces, necessary for its usage in the field of dentistry, such as for orthodontic tooth movement. The ultimate goal of this project is to establish magnetic force-driven orthodontic treatment as a future treatment modality for comprehensive orthodontic treatment.In order to utilize magnets for orthodontic treatment, we must first understand the characteristics of tooth movement created by magnetic forces. In this study, we aimed to digitally assess the efficacy of magnetic attraction and repulsion forces by means of a 3D digital analysis of movement (distance, direction, angulation and duration) and rotation (yaw, pitch and roll) of the crown and root of teeth in an ex vivo typodont model. We performed space closure and space gain treatment of maxillary central incisors (n = 30) and analyzed the movement and rotation of the teeth and root apex with 3D digital analysis. The results of the typodont model indicated significant differences on amount, speed and rotation of tooth and root movement created by magnetic attraction and repulsion forces.We also mimicked a moderate crowding typodont case and successfully treated it with a combination of attraction and repulsion magnetic forces. The moderate crowding case utilized magnets and a titanium archwire to guide the planned tooth movements and prevent undesired or unexpected movement. Further ex vivo experiments and considerations for biosafety will be necessary to investigate magnet force-driven orthodontics as a future modality of orthodontic treatment.

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Effect of static magnetic field on pain level and expression of P2X3 receptors in the trigeminal ganglion in mice following experimental tooth movement

Zhu

Wang

Long

et al. 2016

Bioelectromagnetics

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Recent research has demonstrated that static magnetic fields (SMF) can generate an analgesic effect in different conditions. The present study explored effects of SMF on pain levels and expressions of P2X3 receptors in trigeminal ganglion (TG) in mice after experimental tooth movement (tooth movement induced by springs between teeth). Experiments were performed in male mice (body mass: 25-30 g) and divided into SMF + force group, force group, and no force group. Exposure time was over 22 h per day. Mouse Grimace Scale was used for evaluating orofacial pain levels during experimental tooth movement at 4 h and 1, 3, 7, and 14 days. Meanwhile, expression levels of P2X3 receptors in the TG were evaluated by immunohistochemistry and western blotting at same time points. We finally found that during experimental tooth movement, pain levels of mice peaked at 3 days, and then decreased. While pain levels of mice were reduced in the SMF environment at 4 h, 1 and 3 days, there was a significant difference at 1 and 3 days. Meanwhile, under the action of SMF, expression levels of P2X3 receptors in TG were significantly lower at 4 h, 3 and 7 days. These results suggest that SMF can reduce pain levels in mice, and down-regulate P2X3 receptors in TG. Bioelectromagnetics. 38:22-30, 2017. © 2016 Wiley Periodicals, Inc.

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Medizinische Relevanz von Magnetfeldern zur Schmerztherapie

Abstract: Static magnetic fields are ineffective with respect to pain therapy. Dynamic magnetic fields show diverse effects. Hence, this therapy should be researched in depth.

Cited by 9 publications

References 35 publications

Efficacy and safety of the pulsed electromagnetic field in osteoarthritis: a meta-analysis

Efficacy and safety of the pulsed electromagnetic field in osteoarthritis: a meta-analysis

3D digital analysis of magnetic force-driven orthodontic tooth movement

Effect of static magnetic field on pain level and expression of P2X3 receptors in the trigeminal ganglion in mice following experimental tooth movement

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