Melanin nanoparticles: Antioxidant activities and effects on γ-ray-induced DNA damage in the mouse

Rageh, Monira M.; El-Gebaly, Reem H.

doi:10.1016/j.mrgentox.2018.01.009

Cited by 28 publications

(10 citation statements)

References 50 publications

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“…Therefore, modulating OS by scavenging ROS might be an effective measure to attenuate hypoxic‐ischemic and reperfusion injury. According to previous reports (Rageh & El‐Gebaly, 2018 ; Zhong et al, 2019 ), our data showed that MNPs exhibited the capacity to scavenge ROS and superoxide, which is beneficial for protecting against hypoxic‐ischemic injury. Previous studies have shown that antioxidation is one of the protective mechanisms of MSCs against ischemic brain injury (Calió et al, 2014 ).…”

Section: Discussionsupporting

confidence: 81%

Melanin nanoparticles enhance the neuroprotection of mesenchymal stem cells against hypoxic‐ischemic injury by inhibiting apoptosis and upregulating antioxidant defense

Tang

Luo

Yan

et al. 2022

Cell Biology International

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Polydopamine nanoparticles are artificial melanin nanoparticles (MNPs) that show strong antioxidant activity. The effects of MNPs on the neuroprotection of mesenchymal stem cells (MSCs) against hypoxic‐ischemic injury and the underlying mechanism have not yet been revealed. In this study, an oxygen–glucose deprivation (OGD)‐injured neuron model was used to mimic neuronal hypoxic‐ischemic injury in vitro. MSCs pretreated with MNPs and then cocultured with OGD‐injured neurons were used to investigate the potential effects of MNPs on the neuroprotection of MSCs and to elucidate the underlying mechanism. After coculturing with MNPs‐pretreated MSCs, MSCs, and MNPs in a transwell coculture system, the OGD‐injured neurons were rescued by 91.24%, 79.32%, and 59.97%, respectively. Further data demonstrated that MNPs enhanced the neuroprotection against hypoxic‐ischemic injury of MSCs by scavenging reactive oxygen species and superoxide and attenuating neuronal apoptosis by deactivating caspase‐3, downregulating the expression of proapoptotic Bax proteins, and upregulating the expression of antiapoptotic Bcl‐2 proteins. These findings suggest that MNPs enhance the neuroprotective effect of MSCs against hypoxic‐ischemic injury by inhibiting apoptosis and upregulating antioxidant defense, which could provide some evidence for the potential application of combined MNPs and MSCs in the therapy for ischemic stroke.

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Section: Discussionsupporting

confidence: 81%

Melanin nanoparticles enhance the neuroprotection of mesenchymal stem cells against hypoxic‐ischemic injury by inhibiting apoptosis and upregulating antioxidant defense

Tang

Luo

Yan

et al. 2022

Cell Biology International

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“…Compared with small‐molecule ROS scavengers, catalytic antioxidants have the advantages of simple manufacturing process, high operability and easy production on a large scale, as well as advanced surface functionalization with stimuli‐sensitive polymers (e.g., pH‐ and H 2 O 2 ) and organelle‐directed molecules. Here, we focus on several typical NPs with antioxidant activity including Pt NPs, [ 94 ] melanin NPs (Me NPs), [ 95 ] prussian blue NPs (PB NPs), [ 96 ] manganese oxide (Mn NPs), [ 97 ] nickel oxide (NiO), [ 98 ] cerium oxide (CeO 2 ), [ 99 ] and some 2D layered nanomaterials. Many of them possess inherently high SOD‐ or CAT‐like activities.…”

Section: Ros‐associated Nanomedicines For Disease Treatmentsmentioning

confidence: 99%

“…For Me NPs, it is well known as a potential radical scavenger. [ 95,103,104 ] Liu et al. revealed its multi‐antioxidative mechanisms, demonstrating the antioxidant potential to reactive oxygen and nitrogen species (RONS) in vitro and in a rat model of ischemic stroke ( Figure ).…”

Section: Ros‐associated Nanomedicines For Disease Treatmentsmentioning

confidence: 99%

Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment

et al. 2020

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Reactive oxygen species (ROS) play an essential role in physiological and pathological processes. Studies on the regulation of ROS for disease treatments have caused wide concern, mainly involving the topics in ROS‐regulating therapy such as antioxidant therapy triggered by ROS scavengers and ROS‐induced toxic therapy mediated by ROS‐elevation agents. Benefiting from the remarkable advances of nanotechnology, a large number of nanomaterials with the ROS‐regulating ability are developed to seek new and effective ROS‐related nanotherapeutic modalities or nanomedicines. Although considerable achievements have been made in ROS‐based nanomedicines for disease treatments, some fundamental but key questions such as the rational design principle for ROS‐related nanomaterials are held in low regard. Here, the design principle can serve as the initial framework for scientists and technicians to design and optimize the ROS‐regulating nanomedicines, thereby minimizing the gap of nanomedicines for biomedical application during the design stage. Herein, an overview of the current progress of ROS‐associated nanomedicines in disease treatments is summarized. And then, by particularly addressing these known strategies in ROS‐associated therapy, several fundamental and key principles for the design of ROS‐associated nanomedicines are presented. Finally, future perspectives are also discussed in depth for the development of ROS‐associated nanomedicines.

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“…Schweitzer et al showed that the systemic administration of melanin-covered NPs reduced the hematologic toxicity in CD-1 mice exposed to external radiation or radioimmunotherapy [ 107 ]. In addition, another study revealed that the pre-treatment of Chinese hamster ovary cells with MEL-NPs (6.25, 12.5, 25 and 50 µg/mL) attenuated gamma radiation-induced cytotoxicity [ 108 ].…”

Section: Melanin-based Targeted Cancer Therapymentioning

confidence: 99%

Melanin and Melanin-Functionalized Nanoparticles as Promising Tools in Cancer Research—A Review

Marcovici

Coricovac

Pînzaru

et al. 2022

Cancers

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Cancer poses an ongoing global challenge, despite the substantial progress made in the prevention, diagnosis, and treatment of the disease. The existing therapeutic methods remain limited by undesirable outcomes such as systemic toxicity and lack of specificity or long-term efficacy, although innovative alternatives are being continuously investigated. By offering a means for the targeted delivery of therapeutics, nanotechnology (NT) has emerged as a state-of-the-art solution for augmenting the efficiency of currently available cancer therapies while combating their drawbacks. Melanin, a polymeric pigment of natural origin that is widely spread among many living organisms, became a promising candidate for NT-based cancer treatment owing to its unique physicochemical properties (e.g., high biocompatibility, redox behavior, light absorption, chelating ability) and innate antioxidant, photoprotective, anti-inflammatory, and antitumor effects. The latest research on melanin and melanin-like nanoparticles has extended considerably on many fronts, allowing not only efficient cancer treatments via both traditional and modern methods, but also early disease detection and diagnosis. The current paper provides an updated insight into the applicability of melanin in cancer therapy as antitumor agent, molecular target, and delivery nanoplatform.

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Melanin nanoparticles: Antioxidant activities and effects on γ-ray-induced DNA damage in the mouse

Cited by 28 publications

References 50 publications

Melanin nanoparticles enhance the neuroprotection of mesenchymal stem cells against hypoxic‐ischemic injury by inhibiting apoptosis and upregulating antioxidant defense

Melanin nanoparticles enhance the neuroprotection of mesenchymal stem cells against hypoxic‐ischemic injury by inhibiting apoptosis and upregulating antioxidant defense

Reactive Oxygen Species‐Regulating Strategies Based on Nanomaterials for Disease Treatment

Melanin and Melanin-Functionalized Nanoparticles as Promising Tools in Cancer Research—A Review

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