Melanocytes in Odontogenic Keratocyst

Takeda, Yasunori; Kuroda, Masafumi; Suzuki, Atsumi; Fujioka, Yukio

doi:10.1111/j.1440-1827.1985.tb00631.x

Cited by 18 publications

(23 citation statements)

References 10 publications

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“…The racial factor may play an important one in pigmented odontogenic lesions, since most patients with pigmented odontogenic lesions are Asian or Black (7,(8)(9)(10)(11)(12)(13)(14)(15). However, the limited number of cases does not give any statistical value to the data.…”

Section: Discussionmentioning

confidence: 87%

“…In another series of 278 odontogenic keratocysts, only one patient, who was an American Black, exhibited melanin-pigmentation. In a study of 47 Japanese patients with odontogenic keratocysts, we found melanocytes and/or melanin-pigment in five patients (8). Only one case of pigmented odontogenic keratocyst was reported in a White patient (18).…”

Section: Discussionmentioning

confidence: 99%

“…We have studied the occurrence and distribution of melanocytes and melanin-pigment in intra-osseous odontogenic lesions, and discuss their possible histogenesis and pathological significance in the jaw lesions (8)(9)(10)(11)(12)(13)(14)(15)(16). The present paper reports a case of dentigerous cyst with melanin-pigmented epithelial lining in the belief that this represents a not previously described component within the spectrum of odontogenic cysts.…”

Section: Introductionmentioning

confidence: 94%

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Case report of a pigmented dentigerous cyst and a review of the literature on pigmented odontogenic cysts.

Takeda¹,

Yamamoto²

2000

Journal of Oral Science

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Abstract:This paper reports the first case of a dentigerous cyst containing melanin-pigment and melanocytes in the lining epithelium, and the first case of a odontogenic cyst with macroscopically visible pigmentation in the cyst wall. The patient was a 29-yearold Japanese male with a cystic lesion in the left retromolar area of the mandible. Pathologic examination revealed the lesion to be a dentigerous cyst with or without mild surface keratinization, and numerous granules of melanin-pigment were distributed in the basal cells of the epithelial lining. Furthermore, dendritic melanocytes were scattered in the basal layer. Review of the literature revealed that pigmented odontogenic cysts are uncommon, and only 11 cases have been documented; eight were odontogenic keratocyst, one was a gingival cyst, one was a botryoid odontogenic cyst, and one was a lateral periodontal cyst. The possible origin of melanocytes in odontogenic lesions is discussed. (J. Oral Sci. 42, 43-46, 2000)

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

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Case report of a pigmented dentigerous cyst and a review of the literature on pigmented odontogenic cysts.

Takeda¹,

Yamamoto²

2000

Journal of Oral Science

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“…However, a few reports on invasive SCC or intraepithelial squamous neoplasia with melanocytic hyperplasia, namely pigmented SCC, have been reported in certain organs, such as skin, oral mucosa, nasal cavity and uterine cervix (1)(2)(3)(4). The squamous epithelium of KCOT usually does not contain melanocytes, however, cases of pigmented KCOT have been documented, albeit extremely rarely (5)(6)(7)(8). In the present study, we described an additional case of pigmented KCOT and review the clinicopathological features of this extremely rare lesion.…”

Section: Introductionmentioning

confidence: 99%

“…These patients were of West Indian and African origins, respectively (Table I). However, Takeda et al (7) reported that the prevalence of pigmented KCOT was 10.6% (5/47 cases) in the Japanese population and this difference in frequency of pigmented KCOT may be related to ethnicity (7). Takeda et al (7) reported a series of pigmented KCOT and they described two distinct histopathological patterns of this lesion.…”

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confidence: 99%

Pigmented keratocystic odontogenic tumor: A case report with review of the literature

Ishida

Koshinuma

Oue

et al. 2013

Molecular and Clinical Oncology

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Abstract. Keratocystic odontogenic tumor (KCOT) is a relatively rare benign neoplasm of odontogenic origin. The squamous epithelium of KCOT usually does not contain melanocytes, however, pigmented KCOT has been documented, albeit extremely rarely. In the present study, we described an additional case of pigmented KCOT and review the clinicopathological features of this extremely rare lesion. A 23-year-old Japanese female presented with a relatively wellcircumscribed round unilocular radiolucency that impacted the third molar in her right mandibula. Surgical resection was performed subsequent to a clinical diagnosis of KCOT. Histopathological study of the resected mandibular cyst showed that it was covered by a parakeratinized stratified squamous epithelium, which had slightly enlarged hyperchromatic nuclei. On the luminal surface, a wavy layer of parakeratin was observed. In addition, dendritic melanocytes without atypia were observed in approximately half of the squamous epithelium. Immunohistochemical analyses revealed that these melanocytes were positive for S-100 protein, Melan-A and HMB-45. Therefore, a diagnosis of pigmented KCOT was made. Review of the clinicopathological features of the previously reported cases of pigmented KCOT as well as the present case revealed that: i) this lesion occurs mostly in young persons (average age, 18 years) and shows female predominance; ii) most cases are solitary and involve the mandibula; and iii) the reported incidence is 0.36-10.6% and this difference may be associated with ethnicity. Thus, we described the ninth reported case of pigmented KCOT. The mechanism by which melanocytes appear and the difference in ethnic prevalence remain unclear. Additional clinicopathological studies are needed to clarify these issues.

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Pigmented adenomatoid odontogenic tumour

Takeda¹

1989

Vichows Archiv A Pathol Anat

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A pigmented adenomatoid odontogenic tumour occurring in the mandible of a 12-year-old Japanese girl is reported. In addition to the characteristic histopathologic features, fine granules and coarse aggregates of melanin pigment were widely distributed in the spindle-shaped epithelial cells between duct-like structures, and dendritic cells containing melanin pigment were also distributed in tumour epithelium. The possible histogenesis of melanin pigment in the epithelial cells of the odontogenic lesions is discussed, although no firm conclusions could be drawn.

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Melanocytes in Odontogenic Keratocyst

Cited by 18 publications

References 10 publications

Case report of a pigmented dentigerous cyst and a review of the literature on pigmented odontogenic cysts.

Case report of a pigmented dentigerous cyst and a review of the literature on pigmented odontogenic cysts.

Pigmented keratocystic odontogenic tumor: A case report with review of the literature

Pigmented adenomatoid odontogenic tumour

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