Melanoma survival in the United States, 1992 to 2005

Pollack, Lori A.; Li, Jun; Berkowitz, Zahava; Weir, Hannah K.; Wu, Xiao‐Cheng; Ajani, Umed A.; Ekwueme, Donatus U.; Li, Chunyu; Pollack, Brian P.

doi:10.1016/j.jaad.2011.05.030

Cited by 162 publications

(196 citation statements)

References 32 publications

(34 reference statements)

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“…Notably, a strong association was observed between NM and NLRP3 rs35829419. Unlike SSM that initially describes a radial growth pattern, NM arises rapidly and grows in a more vertical direction and might be associated with a worse prognosis (Pollack et al, 2011). We hypothesize that this gain-of-function SNP because of increased IL-1b levels, might upregulate other related pro-inflammatory genes like TNF-a and NF-jB through a positive feedback loop, which might promote melanoma cells to resist elimination by the T lymphocytes.…”

Section: Discussionmentioning

confidence: 91%

Inflammasome polymorphisms confer susceptibility to sporadic malignant melanoma

Verma

Bivik

Farahani

et al. 2012

Pigment Cell Melanoma Res

106

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SummaryGenetic variants of NLRP3 and NLRP1 are known to modulate levels of pro‐inflammatory cytokine interleukin (IL)‐1β. The purpose of this study was to investigate the association of NLRP3/NLRP1 polymorphisms with susceptibility and clinical features of malignant melanoma in a Swedish case–control study. Common variants in NLRP3/NLRP1 were investigated in sporadic malignant melanoma patients and healthy controls followed by analysis using logistic regression. NLRP3 variant (rs35829419) was significantly more common in male patients than in controls (OR, 2.22; CI, 1.27–3.86). Upon stratification, significant association with nodular melanoma was observed (OR, 2.89; CI, 1.33–6.30), which intensified in male patients (OR 4.03, CI 1.40–11.59). The NLRP1 variant (rs12150220) was significantly more common in fair‐skinned female patients (OR, 1.85; CI, 1.04–3.33) and showed strong associations with nodular melanoma (OR, 6.03; CI, 1.33–25). Our data suggest that NLRP3/NLRP1 polymorphisms are associated with melanoma susceptibility; these findings warrant validation in other independent populations.

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Section: Discussionmentioning

confidence: 91%

Inflammasome polymorphisms confer susceptibility to sporadic malignant melanoma

Verma

Bivik

Farahani

et al. 2012

Pigment Cell Melanoma Res

106

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“…Melanoma comprises $3.3 billion of the total $8.1 billion in all direct skin cancer annual costs (16). Indirect costs associated with melanoma are estimated to be as high as over $3.5 billion annually (17). As incidence and mortality rises, costs for treatment and indirect care are projected to concurrently rise (15).…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Melanoma

Matthews

Qureshi

et al. 2017

Cutaneous Melanoma: Etiology and Therapy

274

321

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Melanoma is a potentially lethal cancer that is most commonly cutaneous. The worldwide incidence of melanoma has risen rapidly over the course of the last 50 years. Its incidence is greatest among fair-skinned populations, and in regions of lower latitude. Incidence is greater among geriatric populations, but melanoma is also among the most common cancers found in adolescent and young adult populations. In fact, it is one of the leading cancers in average years of life lost per death from disease. Melanoma incidence varies by sex, which is also associated with differences in melanoma anatomic site. Similar differences by region, ethnicity, age, and sex are observed in mortality rates of melanoma. In the setting of rising incidence and mortality, melanoma bears a heavy health and economic burden. Attributable costs are several billion in nations with greater melanoma incidence. Preventative strategies have been implemented in multiple high-risk regions with variable success. It is imperative that research efforts Epidemiology of Melanoma 4 achieve better understanding of the risk factors and etiology of disease, with the goal to halt and reverse the progressive trend of rising incidence and mortality from melanoma.

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“…As a result, the ability of LMMs to metastasize and their rising incidence rate over the past decades are often trivialized, leading to a lack of follow-up standards as well as of current data from epidemiological studies [12, 15]. Therefore, it is absolutely necessary to analyze and define prognostic factors influencing the progression of disease and survival [16]. In this study, we aimed to focus on recurrence, progression, and overall survival of LMM managed with primary wide local excision.…”

Section: Introductionmentioning

confidence: 99%

A Retrospective Cohort Study on Patients with Lentigo Maligna Melanoma

et al. 2019

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Background: More epidemiological data about lentigo maligna melanoma (LMM) are required to define follow-up guidelines. The study focused on recurrence, progression, and overall survival of LMM managed with primary wide local excision. Methods: In a 23-year retrospective study (1994 to 2016), a cohort of patients with LMM was evaluated by collecting data about the tumor location, the Breslow depth, the presence of ulceration, and patients’ age and sex. Local recurrences, locoregional and distant metastases, and disease-free and overall survival were additionally assessed. Results: Overall, 150 cases (84 male, 66 female, mean age 71.3 ± 11.3 years) of single, localized, primary LMM with a mean follow-up of 6.6 ± 4.4 years were included. A total of 33 (22.2%) patients underwent sentinel lymph node biopsy (SLNB) during surgical excision. However, positive SLNB was detected in none of them. The multivariable Cox analysis indicated that age of diagnosis and male gender significantly influenced the overall survival, while a shorter disease-free survival could be correlated with a greater Breslow thickness. The metastatic potential turned out to be low, entailing 7 deaths in the context of the LMM. Conclusion: Male gender, age over 70 at diagnosis, and a Breslow thickness greater than 0.75 mm were associated with a statistically significant decrease in overall disease-free survival in the current study. The results of the study confirm the favorable outcome of LMM. However, diagnosed patients should undertake regular follow-ups. The intensity of follow-up in these patients can be individualized based on the probability of recurrence/metastasis and overall survival. Furthermore, the study showed that SLNB might not be a necessary staging procedure in patients with LMM.

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Melanoma survival in the United States, 1992 to 2005

Abstract: Poorer survival from melanoma was observed among those given the diagnosis at late stage and older age. Improvements in survival over time have been minimal. Although newly available therapies may impact survival, prevention and early detection are relevant to melanoma-specific survival.

Cited by 162 publications

References 32 publications

Inflammasome polymorphisms confer susceptibility to sporadic malignant melanoma

Inflammasome polymorphisms confer susceptibility to sporadic malignant melanoma

Epidemiology of Melanoma

A Retrospective Cohort Study on Patients with Lentigo Maligna Melanoma

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