Melanopsin-dependent light avoidance in neonatal mice

Johnson, John L.; Wu, V.; Donovan, Michael H.; Majumdar, Sriparna; Renterı́a, René C.; Porco, Travis C.; Gelder, Russell N. Van; Copenhagen, David R.

doi:10.1073/pnas.1008533107

Cited by 126 publications

(137 citation statements)

References 43 publications

Supporting

Mentioning

128

Contrasting

Unclassified

Order By: Relevance

“…For nonimage vision, although adaptation is certainly beneficial for increasing the signaling dynamic range, the exact implication of Weber-Fechner behavior is less obvious. Because ipRGCs are now known to also contribute to conscious vision (12,(48)(49)(50)(51)(52), this adaptation behavior may have more to do with the latter function. It would, thus, be useful to know whether the other ipRGC subtypes [which supposedly are more involved in image vision compared with M1 cells (12,15)] show similar adaptation behavior.…”

Section: Discussionmentioning

confidence: 99%

Adaptation to steady light by intrinsically photosensitive retinal ganglion cells

Yau

2013

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Intrinsically photosensitive retinal ganglion cells (ipRGCs) are recently discovered photoreceptors in the mammalian eye. These photoreceptors mediate primarily nonimage visual functions, such as pupillary light reflex and circadian photoentrainment, which are generally expected to respond to the absolute light intensity. The classical rod and cone photoreceptors, on the other hand, mediate image vision by signaling contrast, accomplished by adaptation to light. Experiments by others have indicated that the ipRGCs do, in fact, light-adapt. We found the same but, in addition, have now quantified this light adaptation for the M1 ipRGC subtype. Interestingly, in incremental-flash-on-background experiments, the ipRGC's receptor current showed a flash sensitivity that adapted in background light according to the Weber-Fechner relation, well known to describe the adaptation behavior of rods and cones. Part of this light adaptation by ipRGCs appeared to be triggered by a Ca 2+ influx, in that the flash response elicited in the absence of extracellular Ca 2+ showed a normal rising phase but a slower decay phase, resulting in longer time to peak and higher sensitivity. There is, additionally, a prominent Ca 2+ -independent component of light adaptation not typically seen in rods and cones or in invertebrate rhabdomeric photoreceptors.

show abstract

Section: Discussionmentioning

confidence: 99%

Adaptation to steady light by intrinsically photosensitive retinal ganglion cells

Yau

2013

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…Because it has been shown that light exposure induces avoidance behavior in early postnatal mice (12), light stimuli may increase stress levels of the pups, potentially affecting granule cell migration. Therefore, to comprehensively understand the role of light stimuli in granule cell migration and cerebellar development, it is necessary to examine what degree of light exposure may induce toxic effects on the proliferation, migration, and differentiation of immature neurons.…”

Section: Discussionmentioning

confidence: 99%

“…Even though mice do not open their eyes until approximately postnatal day 12 (P12), it has been reported that light stimuli induce physiological changes well before that time (12). In early postnatal mouse cerebella, granule cell precursors proliferate actively at the top of the external granular layer (EGL) (13).…”

mentioning

confidence: 99%

Light stimuli control neuronal migration by altering of insulin-like growth factor 1 (IGF-1) signaling

Liu

Komuro

Fahrion

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

The role of genetic inheritance in brain development has been well characterized, but little is known about the contributions of natural environmental stimuli, such as the effect of light-dark cycles, to brain development. In this study, we determined the role of light stimuli in neuronal cell migration to elucidate how environmental factors regulate brain development. We show that in early postnatal mouse cerebella, granule cell migration accelerates during light cycles and decelerates during dark cycles. Furthermore, cerebellar levels of insulin-like growth factor 1 (IGF-1) are high during light cycles and low during dark cycles. There are causal relationships between light-dark cycles, speed of granule cell migration, and cerebellar IGF-1 levels. First, changes in lightdark cycles result in corresponding changes in the fluctuations of both speed of granule cell migration and cerebellar IGF-1 levels. Second, in vitro studies indicate that exogenous IGF-1 accelerates the migration of isolated granule cells through the activation of IGF-1 receptors. Third, in vivo studies reveal that inhibiting the IGF-1 receptors decelerates granule cell migration during light cycles (high IGF-1 levels) but does not alter migration during dark cycles (low IGF-1 levels). In contrast, stimulating the IGF-1 receptors accelerates granule cell migration during dark cycles (low IGF-1 levels) but does not alter migration during light cycles (high IGF-1 levels). These results suggest that during early postnatal development light stimuli control granule cell migration by altering the activity of IGF-1 receptors through modification of cerebellar IGF-1 levels. cerebellar granule cells | light stimulation

show abstract

“…By P14 (eye opening), slow activity and rapid activity alternate in cortex with arousal state and sensory input. (Johnson et al, 2010) and electrophysiological Kirkby and Feller, 2013) effects before P8, when we first observed N2. Furthermore, synaptic blockade in retina eliminates visual responses in rats at equivalent ages .…”

Section: High Lowmentioning

confidence: 99%

Development of Activity in the Mouse Visual Cortex

Shen¹,

Colonnese²

2016

J. Neurosci.

124

View full text Add to dashboard Cite

A comprehensive developmental timeline of activity in the mouse cortex in vivo is lacking. Understanding the activity changes that accompany synapse and circuit formation is important to understand the mechanisms by which activity molds circuits and would help to identify critical checkpoints for normal development. To identify key principles of cortical activity maturation, we systematically tracked spontaneous and sensory-evoked activity with extracellular recordings of primary visual cortex (V1) in nonanesthetized mice. During the first postnatal week (postnatal days P4 -P7), V1 was not visually responsive and exhibited long (Ͼ10 s) periods of network silence. Activation consisted exclusively of "slow-activity transients," 2-10 s periods of 6 -10 Hz "spindle-burst' oscillations; the response to spontaneous retinal waves. By tracking daily changes in this activity, two key components of spontaneous activity maturation were revealed: (1) spindle-burst frequency acceleration (eventually becoming the 20 -50 Hz broadband activity caused by the asynchronous state) and (2) "filling-in" of silent periods with low-frequency (2-4 Hz) activity (beginning on P10 and complete by P13). These two changes are sufficient to create the adult-like pattern of continuous activity, alternation between fast-asynchronous and slowsynchronous activity, by eye opening. Visual responses emerged on P8 as evoked spindle-bursts and neuronal firing with a signal-tonoise ratio higher than adult. Both were eliminated by eye opening, leaving only the mature, short-latency response. These results identify the developmental origins of mature cortical activity and implicate the period before eye opening as a critical checkpoint. By providing a systematic description of electrical activity development, we establish the murine visual cortex as a model for the electroencephalographic development of fetal humans.

show abstract

Melanopsin-dependent light avoidance in neonatal mice

Cited by 126 publications

References 43 publications

Adaptation to steady light by intrinsically photosensitive retinal ganglion cells

Adaptation to steady light by intrinsically photosensitive retinal ganglion cells

Light stimuli control neuronal migration by altering of insulin-like growth factor 1 (IGF-1) signaling

Development of Activity in the Mouse Visual Cortex

Contact Info

Product

Resources

About