Melatonin and 1400 W Ameliorate both Intestinal and Remote Organ Injury Following Mesenteric Ischemia/Reperfusion

Kesik, Vural; Güven, Ahmet; Vurucu, Sebahattin; Tunç, Turan; Uysal, Bülent; Gündoğdu, Gökhan; Öztaş, Emin; Korkmaz, Ahmet

doi:10.1016/j.jss.2008.12.024

Cited by 33 publications

(22 citation statements)

References 49 publications

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“…On the other hand, recent studies clearly demonstrated that excessive NO formation causes renal injury following ischemia reperfusion insults. 8,23,40,44,45 Our findings are also consistent with these reports, in which some of them found that OT protected kidney against I/ R injury through blocking formation of endogenous NO. So, it can be concluded that renal injury following SWT originates from excessive production of NO and ONOO À as seen at renal I/R injury.…”

Section: Discussionsupporting

confidence: 91%

“…17,18 It was also demonstrated that ozone increases antioxidant enzyme activities such as glutathione peroxidase (GSHPx), SOD, and catalase (CAT), preparing the host to face physiopathological conditions mediated by ROS/ RNS. 16,19 Ameliorative effects of OT on oxidative and nitrosative stress have been reported in different experimental models such as renal ischemia/reperfusion injury, 20 necrotizing pancreatitis, 21 caustic esophageal burn, 22 and necrotizing enterocolitis 23 by our research group. Based on these data and observations, we designed this study to find out whether OT has an ameliorative effect on ESW-induced renal injury in an experimental model of rats.…”

Section: Introductionmentioning

confidence: 85%

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Medical ozone therapy reduces shock wave therapy-induced renal injury

et al. 2016

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Objectives: Extracorporeal shock wave (ESW) lithotripsy is the preferred treatment modality for uncomplicated kidney stones. More recently free oxygen radical production following ESW application has been considered to be crucial in shock wave-induced renal damage. It has been shown that ozone therapy (OT) has ameliorative and preventive effects against various pathological conditions due to increased nitro-oxidative stress. In current study, we aimed to evaluate the efficacy of OT against ESW-induced renal injury. Methods: Twenty-four male Sprague-Dawley rats were divided into three groups: sham-operated, ESW, and ESW þ OT groups. All groups except shamoperated group were subjected to ESW procedure. ESW þ OT group received 1 mg/kg/day of oxygen/ozone mixture intraperitoneally at 2 h before ESW, and OT was continued once a day for consecutive three days. The animals were killed at the 4th day, and kidney tissue and blood samples were harvested for biochemical and histopathologic analysis. Results: Serum ALT and AST levels, serum neopterin, tissue nitrite/nitrate levels, and tissue oxidative stress parameters were increased in the ESW group and almost came close to control values in the treatment group (p < 0.05, ESW vs. ESW þ OT). Histopathological injury scores were significantly lower in treatment group than the ESW group (p < 0.05, ESW vs. ESW þ OT). Immunohistochemical iNOS staining scores in ESW group were higher than those of sham-operated group (p < 0.05, ESW vs. sham-operated), iNOS staining scores in OT group were significantly lower than the ESW group (p < 0.05, ESW þ OT vs. ESW). Conclusion: OT ameliorates nitro-oxidative stress and reduces the severity of pathological changes in the experimental ESW-induced renal injury of rat model. ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 85%

Medical ozone therapy reduces shock wave therapy-induced renal injury

et al. 2016

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“…The critical ischemic period is dependent on the organ, and is about 15-20 minutes (min) in the liver and kidney (2). Reperfusion of the superior mesenteric artery (SMA) causes activation of reactive oxygen species (ROS) and reactive nitrogen species (RNS), and a large amount of nitric oxide, proinflammatory and inflammatory cytokines and transcription factors are activated after mesenteric I/R injury and circulate via both the venous and lymphatic system, inducing remote organ injury (3,4) including the lungs, kidneys and liver (4,5). ROS formation results in injury via various biomolecules found in tissues, including membrane lipids, nucleic acids, enzymes, and receptors.…”

Section: Introductionmentioning

confidence: 99%

The protective effects of curcumin on intestine and remote organs against mesenteric ischemia/reperfusion injury

Önder¹,

Kapan²,

Gümüş³

et al. 2012

Turk J Gastroenterol

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“…1400W is a known highly selective inhibitor for iNOS in rat tissue and administrated dose of agents in the current study was chosen by considering previous studies. 34,35 Moreover, it is well known that release of mediators commence after acute inflammation and continue consecutive three days based on acute inflammation studies of animal models. 36,37 To reach effective plasma concentration, 1400W (10 mg/kg body weight) was administered before SWT procedure and continued consecutive three days with the aim of defining the role of NO formation in acute phase of this process.…”

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confidence: 99%

Inhibition of inducible nitric oxide synthase prevents shock wave therapy induced renal injury

Fırat¹,

Malkoç

Demirer³

et al. 2014

Renal Failure

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Objectives: Shock wave lithotripsy treatment (SWT) is not completely free from side effects; one of the accused mechanisms for renal injury during SWT is oxygen-and nitrogen-derived free radical productions. Therefore, we aimed to evaluate the effect of inhibition of nitric oxide (NO) production by N-[3(aminomethyl) benzyl) acetamidine] (1400W), highly selective inducible nitric oxide synthase (iNOS) inhibitor, at SWT-induced kidney damage. Materials and methods: Twenty-four rats those underwent right nephrectomy procedure were divided equally into three groups as control, SWT, and SWT + 1400W. 1400W was administered at a dose of 10 mg/kg at 2 h prior to SWT procedure and at the beginning of SWT procedure via intraperitoneal route and continued daily for consecutive 3 days. At the end of the fourth day, animals were killed via decapitation and trunk blood and the left kidneys were taken for biochemical and histopathologic evaluation. Results: SWT caused renal tubular damage and increased lipid peroxidation and antioxidant enzyme activities and SWT also significantly increased nitro-oxidative products. Inhibition of iNOS via administration of 1400W ameliorated renal injury and decreased tissue lipid peroxidation (malondialdehyde), superoxide dismutase, glutathione peroxidase and nitrite/nitrate levels (NO x ). In addition, it was seen that histolopathological changes were attenuated in the SWT + 1400W group when compared to SWT group. Conclusion: SWT-induced renal injury might be due to excessive production of oxygen free radicals and NO production. Inhibition of iNOS attenuates renal injury following SWT treatment. It can be concluded that iNOS inhibitors or peroxynitrite scavengers might be used to protect the kidneys against SWT-induced morphological and functional injuries.

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Melatonin and 1400 W Ameliorate both Intestinal and Remote Organ Injury Following Mesenteric Ischemia/Reperfusion

Cited by 33 publications

References 49 publications

Medical ozone therapy reduces shock wave therapy-induced renal injury

Medical ozone therapy reduces shock wave therapy-induced renal injury

The protective effects of curcumin on intestine and remote organs against mesenteric ischemia/reperfusion injury

Inhibition of inducible nitric oxide synthase prevents shock wave therapy induced renal injury

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