Melatonin, antioxidant capacity, and male reproductive function

Mohammadghasemi, Fahimeh

doi:10.1016/b978-0-12-815972-9.00026-3

Cited by 3 publications

(3 citation statements)

References 62 publications

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“…Naturally male reproductive system has two types of antioxidant systems, namely enzymatic and non-enzymatic agents. The enzymatic agents include SOD, CAT, glutathione peroxidase, glutathione reductase, and glutathione-s-transferase [ 11 ]. Non-enzymatic agents are vitamins A, E, C, B-complex, melatonin, resveratrol, copper, and selenium [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…The enzymatic agents include SOD, CAT, glutathione peroxidase, glutathione reductase, and glutathione-s-transferase [ 11 ]. Non-enzymatic agents are vitamins A, E, C, B-complex, melatonin, resveratrol, copper, and selenium [ 11 ]. Our findings showed no significant statistical differences in CAT activity between groups.…”

Section: Discussionmentioning

confidence: 99%

“…In testis tissue, due to the continuation of the spermatogenesis process, the proliferation and metabolism of germ cells are high. On the other hand, testicular tissue possesses a high amount of unsaturated fatty acids, therefore, the testicles may be an environment with high production of reactive oxygen species (ROS) [ 11 ]. Due to the relative insufficient blood flow in testis, testicles are very susceptible to hypoxia and oxidative stress [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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The amelioration of nicotine-induced reproductive impairment in male mouse by Sambucus ebulus L. fruit extract

et al. 2021

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Nicotine as a toxic agent in cigarette smoke impairs the reproductive system. Sambucus ebulus extract (SEE) is shown to have some beneficial effects such as antioxidant properties. The aim of this study was to evaluate the effects of SEE on the hormones of the pituitary-gonadal axis, lipid peroxidation index, antioxidant enzymes, spermatogenesis, and epididymal sperm parameters in male mice treated with nicotine. Adult male mice were divided into five groups; A: normal saline, B: 1 mg/kg nicotine, C: 1 mg/kg nicotine and 10 mg/kg SEE, D: 1 mg/kg nicotine and 50 mg/kg SEE, D: 1 mg/kg nicotine and 100 mg/kg SEE. Treatments lasted for 35 days. The spermicidal activity of SEE was tested in vitro. Sperm count, motility and morphology were assessed for fertility. Serum testosterone, prolactin and luteinizing hormone (LH) were measured, using ELISA. Serum malondialdehyde (MDA), catalase (CAT), and superoxide dismutase (SOD) activity were measured, using colorimetric assays. Spermatogenesis was evaluated by Johnsen's score and morphometry in histological slides. SEE at different doses did not have any spermicidal activity. Sperm parameters were reduced in the nicotine-treated group, compared with controls (P<0.01). Nicotine reduced testosterone and LH levels (P<0.01) and increased prolactin (P<0.01). A hike in MDA and a reduction in SOD activity without change on CAT, were observed in the nicotine group. Nicotine caused hypospermatogenesis. SEE improved most of the above-mentioned parameters, especially in the doses of 50 and 100 mg/kg. Beneficial effects of SEE in the doses of 50 and 100 mg/kg on male reproduction impairment, induced by nicotine might be partly attributed to the reduction of oxidative stress and changes in the hormones of the pituitary-gonadal axis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The amelioration of nicotine-induced reproductive impairment in male mouse by Sambucus ebulus L. fruit extract

et al. 2021

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An elderberry-supplemented diet improves spermatogenesis in mice with busulfan-induced azoospermia

Balani

Novin

Alvani

et al. 2022

Reprod. Fertil. Dev.

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Context Approximately 40–50% of all infertility cases are due to male infertility, and one of the most important causes of infertility is azoospermia. Aims This study aimed to evaluate the potential effect of elderberry on the spermatogenesis process in the azoospermia mice model. Method Thirty adult male mice were randomised into three groups: control; busulfan (45 mg/kg); and busulfan + elderberry (2%), 6 mL orally per animal. Sperm samples were collected from the tail of the epididymis, and testis specimens were also collected and then subjected to sperm parameters analysis, histopathological evaluation, reactive oxygen species (ROS), and glutathione (GSH) measurement to determine the mRNA expression and hormonal assay. Conclusions It can be concluded that the elderberry diet may be considered a complementary treatment to improve the spermatogenesis process in busulfan-induced azoospermic mice. Implications Considering some limitations, the elderberry diet can be an alternate option for improving testicular damage following chemotherapy.

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Tocopherol Alleviates Oxidative Stress and Increases Androgen Receptors in Mice Testicular Tissues under Forced Swimming in Warm Water

Daeihamed,

Fallah Kochakam,

Taghizadeh Valdi

et al. 2024

Andrologia

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The purpose of this study was to investigate the effect of tocopherol supplementation and swimming in warm water on the spermatogenesis, expression of androgen receptors (ARs), and oxidative stress markers in mouse testis. Adult male mice were divided into seven groups: (A) control, (B) solvent, (C) vitamin E (VE), (D) swimming at 23°C water, (E) swimming at 23°C water and receiving VE, (F) swimming at 35°C water, and (G) swimming at 35°C water and receiving VE. Hormones were measured using ELISA. Spermatogenesis was examined through histopathology. The ARs were studied by immunohistochemistry. The testis oxidative stress markers were assessed using colorimetric assays. The distribution of VE in testis tissue was also evaluated using high-performance liquid chromatography (HPLC). Swimming of mice at 23°C was safe for sperm development. Swimming at 35°C resulted in lower testosterone, LH, sperm parameters, sperm differentiation, AR expression, SOD activity, and increased MDA in the testis, compared to control (P <0.05). The abovementioned parameters were significantly altered by VE, in comparison to the animals that swam in warm water at 35°C (P <0.05). The results of HPLC showed that tissue distribution of VE was significantly higher in group G, compared to group E (P <0.05). Swimming in water at 23°C is conducive to sperm development, whereas swimming at 35°C impairs sperm production. In conclusion, VE counteracts the negative effects of swimming at 35°C water on sperm development by altering the hypothalamic–pituitary–gonadal axis, distribution of VE, AR expression, and lipid peroxidation in testicular tissue.

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Melatonin, antioxidant capacity, and male reproductive function

Cited by 3 publications

References 62 publications

The amelioration of nicotine-induced reproductive impairment in male mouse by Sambucus ebulus L. fruit extract

The amelioration of nicotine-induced reproductive impairment in male mouse by Sambucus ebulus L. fruit extract

An elderberry-supplemented diet improves spermatogenesis in mice with busulfan-induced azoospermia

Tocopherol Alleviates Oxidative Stress and Increases Androgen Receptors in Mice Testicular Tissues under Forced Swimming in Warm Water

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