Melatonin Attenuates Dextran Sodium Sulfate Induced Colitis with Sleep Deprivation: Possible Mechanism by Microarray Analysis

Chung, Sung Pil; Park, Sung Chul; Kim, Ok Soon; Kim, Ja Hyun; Baik, Haing Woon; Hong, Young Ok; Kim, Sang Su; Shin, Jae-Ho; Jun, Jae-Hoon; Jo, Yunju; Ahn, Sang Bong; Jo, Young-Soo; Son, Byoung Kwan; Kim, Seong Hwan

doi:10.1007/s10620-013-3013-2

Cited by 31 publications

(21 citation statements)

References 49 publications

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“…Based on these results, adiponectin expression in colonic tissue might be modulated by melatonin injection. These results are comparable to genetic expression of adiponectin after melatonin treatment in our previous study[14]. …”

Section: Discussionsupporting

confidence: 90%

“…In our previous study, we found the genetic expression of adiponectin after melatonin injection with sleep deprivation using microarray and PCR[14]. Here, we tried to confirm the tissue expression of adiponectin after melatonin injection through immunohistochemical staining (Figure 4) and Western blotting (Figure 6).…”

Section: Discussionmentioning

confidence: 98%

“…The melatonin in GI tract has anti-inflammatory effect in experimental models of colitis in many previous reports[9-13]. Our previous study also shows that mRNA level of adiponectin is down regulated by sleep deprivation but up-regulated by melatonin based on microarrays and real-time PCR analysis of mice colon tissues[14]. Currently, the relationship between melatonin and adiponectin on colitis with sleep deprivation remains unknown.…”

Section: Introductionmentioning

confidence: 92%

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Melatonin modulates adiponectin expression on murine colitis with sleep deprivation

Kim¹,

Park²,

Baik³

et al. 2016

WJG

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AIMTo determine adiponectin expression in colonic tissue of murine colitis and systemic cytokine expression after melatonin treatments and sleep deprivation.METHODSThe following five groups of C57BL/6 mice were used in this study: (1) group I, control; (2) group II, 2% DSS induced colitis for 7 d; (3) group III, 2% DSS induced colitis and melatonin treatment; (4) group IV, 2% DSS induced colitis with sleep deprivation (SD) using specially designed and modified multiple platform water baths; and (5) group V, 2% DSS induced colitis with SD and melatonin treatment. Melatonin (10 mg/kg) or saline was intraperitoneally injected daily to mice for 4 d. The body weight was monitored daily. The degree of colitis was evaluated histologically after sacrificing the mice. Immunohistochemical staining and Western blot analysis was performed using anti-adiponectin antibody. After sampling by intracardiac punctures, levels of serum cytokines were measured by ELISA.RESULTSSleep deprivation in water bath exacerbated DSS induced colitis and worsened weight loss. Melatonin injection not only alleviated the severity of mucosal injury, but also helped survival during stressful condition. The expression level of adiponectin in mucosa was decreased in colitis, with the lowest level observed in colitis combined with sleep deprivation. Melatonin injection significantly (P < 0.05) recovered the expression of adiponectin. The expression levels of IL-6 and IL-17 were increased in the serum of mice with DSS colitis but decreased after melatonin injection.CONCLUSIONThis study suggested that melatonin modulated adiponectin expression in colonic tissue and melatonin and adiponectin synergistically potentiated anti-inflammatory effects on colitis with sleep deprivation.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 92%

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Melatonin modulates adiponectin expression on murine colitis with sleep deprivation

Kim¹,

Park²,

Baik³

et al. 2016

WJG

Self Cite

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“…Additionally, it was reported that melatonin (10 mg/kg, intraperitoneally, i.p.) attenuated colitis with sleep deprivation in mice by downregulating mRNA of E2F transcription factor (E2F2) and histocompatibility class II antigen A, beta 1 (H2-Aβ1), indicating its clinical potential for patients with inflammatory bowel disease, particularly those suffering from sleep disturbances [171]. Furthermore, melatonin was reported to reduce intestinal ischemia-reperfusion-induced lung injury in rats dose-dependently by activating the expression of N -myc downstream-regulated gene 2 (NDRG2), which was involved in cellular differentiation, development, anti-apoptosis, anti-inflammatory cytokine, and antioxidant [172].…”

Section: Bioactivities Of Melatoninmentioning

confidence: 99%

Dietary Sources and Bioactivities of Melatonin

et al. 2017

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Insomnia is a serious worldwide health threat, affecting nearly one third of the general population. Melatonin has been reported to improve sleep efficiency and it was found that eating melatonin-rich foods could assist sleep. During the last decades, melatonin has been widely identified and qualified in various foods from fungi to animals and plants. Eggs and fish are higher melatonin-containing food groups in animal foods, whereas in plant foods, nuts are with the highest content of melatonin. Some kinds of mushrooms, cereals and germinated legumes or seeds are also good dietary sources of melatonin. It has been proved that the melatonin concentration in human serum could significantly increase after the consumption of melatonin containing food. Furthermore, studies show that melatonin exhibits many bioactivities, such as antioxidant activity, anti-inflammatory characteristics, boosting immunity, anticancer activity, cardiovascular protection, anti-diabetic, anti-obese, neuroprotective and anti-aging activity. This review summaries the dietary sources and bioactivities of melatonin, with special attention paid to the mechanisms of action.

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“…Colitis can be aggravated by stress, like sleep deprivation, and improved by anti-inflammatory agents including melatonin [97]. In microarrays and real-time PCR on the mouse colon, mRNA of adiponectin and AQP8 were downregulated by sleep deprivation and upregulated by melatonin.…”

Section: Aqps In Gut Pathophysiologymentioning

confidence: 99%

Aquaporins in Health and Disease: An Overview Focusing on the Gut of Different Species

Pelagalli

Squillacioti

Mirabella

et al. 2016

IJMS

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Aquaporins (AQPs) play a pivotal role in gut homeostasis since their distribution and function is modulated both in physiological and in pathophysiological conditions. The transport of water and solutes through gut epithelia is essential for osmoregulation and digestive and absorptive functions. This passage is regulated by different AQP isoforms and characterized by their peculiar distribution in the gastrointestinal tract. To date, AQP localization has been identified in the gut and associated organs of several mammalian species by different techniques (immunohistochemical, western blotting, and RT-PCR). The present review describes the modulation of AQP expression, distribution, and function in gut pathophysiology. At the same time, the comparative description of AQP in animal species sheds light on the full range of AQP functions and the screening of their activity as transport modulators, diagnostic biomarkers, and drug targets. Moreover, the phenotype of knockout mice for several AQPs and their compensatory role and the use of specific AQP inhibitors have been also reviewed. The reported data could be useful to design future research in both basic and clinical fields.

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Melatonin Attenuates Dextran Sodium Sulfate Induced Colitis with Sleep Deprivation: Possible Mechanism by Microarray Analysis

Abstract: Melatonin improves and sleep deprivation aggravates inflammation of colitis in mice. Adiponectin, aquaporin 8, E2F2 and H2-Ab1 may be involved in the inflammatory change aggravated by sleep deprivation and attenuated by melatonin.

Cited by 31 publications

References 49 publications

Melatonin modulates adiponectin expression on murine colitis with sleep deprivation

Melatonin modulates adiponectin expression on murine colitis with sleep deprivation

Dietary Sources and Bioactivities of Melatonin

Aquaporins in Health and Disease: An Overview Focusing on the Gut of Different Species

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