Melatonin Supplementation for the Cryopreservation of Canine Sperm

Monteiro, Kianne Silva; Cardoso, Ana Cláudia Pereira; Souza, Stefânia P. de; Murgas, Luís David Solis

doi:10.1089/bio.2022.0009

Cited by 2 publications

(3 citation statements)

References 40 publications

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“…Among the tested antioxidant agents, the most efficient in mitigating the cryodamage in human spermatozoa was melatonin, as reported in a recent meta-analysis [144]. Indeed, the addition of the hormone, a physiological regulator of the circadian rhythm, to cryoprotectants exerts a significant positive effect on sperm progressive motility and viability [144], is currently used for the cryopreservation of spermatozoa from several animal species [149][150][151] and has been also shown to improve the survivability of oocytes and embryos [148]. Such beneficial effects are not surprising considering that melatonin, besides showing antioxidant activity, is an anti-apoptotic and ROS scavenging agent [147].…”

Section: Possible Strategies To Prevent the Damage And New Approaches...mentioning

confidence: 99%

Cryopreservation of Human Spermatozoa: Functional, Molecular and Clinical Aspects

Traini

Vignozzi

Baldi

et al. 2023

IJMS

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Cryopreservation is an expanding strategy to allow not only fertility preservation for individuals who need such procedures because of gonadotoxic treatments, active duty in dangerous occupations or social reasons and gamete donation for couples where conception is denied, but also for animal breeding and preservation of endangered animal species. Despite the improvement in semen cryopreservation techniques and the worldwide expansion of semen banks, damage to spermatozoa and the consequent impairment of its functions still remain unsolved problems, conditioning the choice of the technique in assisted reproduction procedures. Although many studies have attempted to find solutions to limit sperm damage following cryopreservation and identify possible markers of damage susceptibility, active research in this field is still required in order to optimize the process. Here, we review the available evidence regarding structural, molecular and functional damage occurring in cryopreserved human spermatozoa and the possible strategies to prevent it and optimize the procedures. Finally, we review the results on assisted reproduction technique (ARTs) outcomes following the use of cryopreserved spermatozoa.

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Section: Possible Strategies To Prevent the Damage And New Approaches...mentioning

confidence: 99%

Cryopreservation of Human Spermatozoa: Functional, Molecular and Clinical Aspects

Traini

Vignozzi

Baldi

et al. 2023

IJMS

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“…In frozen-thawed pig sperm, 1.0 µM of melatonin presented higher viability and acrosome integrity, lower levels of peroxynitrite, •O 2− , and lipid peroxidation and diminished the levels of total ROS [220]. On the other hand, melatonin supplementation in canine sperm had no effects on it [232].…”

Section: Beneficial Role Of Melatoninmentioning

confidence: 94%

“…Unlike sperm enrichment with melatonin, no differences were observed during cryopreservation in sperm quality of goat semen [221]. Specifically, in several studies, it was shown that the administration of melatonin on both fresh and frozen sperm improved membrane integrity, motility and velocity, capacitation, antioxidant protein quantity, and developmental competence of sperm [222][223][224][225][226][227][228][229][230][231][232][233][234].…”

Section: Beneficial Role Of Melatoninmentioning

confidence: 99%

The Role of Melatonin to Ameliorate Oxidative Stress in Sperm Cells

Makris,

Alevra,

Exadactylos

et al. 2023

IJMS

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It is widely accepted that oxidative stress (OS) coming from a wide variety of causes has detrimental effects on male fertility. Antioxidants could have a significant role in the treatment of male infertility, and the current systematic review on the role of melatonin to ameliorate OS clearly shows that improvement of semen parameters follows melatonin supplementation. Although melatonin has considerable promise, further studies are needed to clarify its ability to preserve or restore semen quality under stress conditions in varied species. The present review examines the actions of melatonin via receptor subtypes and its function in the context of OS across male vertebrates.

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Melatonin Supplementation for the Cryopreservation of Canine Sperm

Cited by 2 publications

References 40 publications

Cryopreservation of Human Spermatozoa: Functional, Molecular and Clinical Aspects

Cryopreservation of Human Spermatozoa: Functional, Molecular and Clinical Aspects

The Role of Melatonin to Ameliorate Oxidative Stress in Sperm Cells

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