Melittin and Breast Cancer: A Brief Review of the Evidence

Varpaei, Hesam Aldin; Yavari, Mohammad; Salesi, Zahra; Derakhti, Ali; Azimzadeh, Shakiba; Esmaeili, Hossein; Jafari, Mozhdeh

doi:10.47755/jnps.1000101

Cited by 3 publications

(1 citation statement)

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“…Through anticancer chemicals, like bee venom and its primary component, melittin, cancer cells can be eliminated by interfering with the cell cycle and apoptotic cell death. In numerous studies, melittin has been shown to have an anticancer activity by causing apoptotic cell death in cancer cells, including those from the prostate, ovary, melanoma, lung, breast, bladder, leukemia, and hepatocellular carcinoma [ 15 , 16 , 17 , 18 ] ( Figure 2 ).…”

Section: Molecular Interaction Of Melittin (Honeybee Venom) In Cancermentioning

confidence: 99%

An Updated Review Summarizing the Anticancer Efficacy of Melittin from Bee Venom in Several Models of Human Cancers

Pandey

Khan

et al. 2023

Nutrients

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Apitherapy (using bee products) has gained broad recognition in cancer therapeutics globally. Honeybee venom has a broad range of biological potential, and its utilization is rapidly emerging in apitherapy. Bee products have significant potential to strengthen the immune system and improve human health. Thus, this review is targeted toward recapitulating the chemo-preventive potential of melittin (MEL), which constitutes a substantial portion of honeybee venom. Honeybee venom (apitoxin) is produced in the venom gland of the honeybee abdomen, and adult bees utilize it as a primary colony defense mechanism. Apitoxin comprises numerous biologically active compounds, including peptides, enzymes, amines, amino acids, phospholipids, minerals, carbohydrates, and volatile components. We are mainly focused on exploring the potential of melittin (a peptide component) of bee venom that has shown promising potential in the treatment of several human cancers, including breast, stomach, lung, prostate, ovary, kidney, colon, gastric, esophageal, cervical cancers, melanoma, osteosarcoma, and hepatocellular carcinoma. This review has summarized all potential studies related to the anticancerous efficacy of melittin (apitoxin), its formulations, conjugates, and nano-formulations against several human carcinomas, which would further pave the way for future researchers in developing potent drugs for cancer management.

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Section: Molecular Interaction Of Melittin (Honeybee Venom) In Cancermentioning

confidence: 99%

An Updated Review Summarizing the Anticancer Efficacy of Melittin from Bee Venom in Several Models of Human Cancers

Pandey

Khan

et al. 2023

Nutrients

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Potential of Melittin to induce apoptosis and overcome multidrug resistance in human colon cancer cell line

Nikodijević,

Jovankić,

Radenković

et al. 2024

Toxin Reviews

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Dual Cytotoxic Responses Induced by Treatment of A549 Human Lung Cancer Cells with Sweet Bee Venom in a Dose-Dependent Manner

Hwang

Kwon

et al. 2022

J Pharmacopuncture

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Objectives: Sweet bee venom (sBV) is purified from Apis mellifera, containing a high level of melittin-its main component. It has been used as a therapeutic agent for pain relief and anti-inflammation, as well as for treating neuronal abnormalities. Recently, there have been studies on the therapeutic application of sBV for anticancer treatment. In the present study, we investigated the pharmacological effect of sBV treatment in A549 human lung cancer cells. Methods: We used microscopic analysis to observe the morphological changes in A549 cells after sBV treatment. The MTT assay was used to examine the cytotoxic effect after dose-dependent sBV treatment. Molecular changes in sBV were evaluated by the expression of apoptosis marker proteins using western blot analysis. Results: Microscopic analysis suggested that the growth inhibitory effect occurred in a dose-dependent manner; however, cell lysis occurred at a concentration over 20 µg/mL of sBV. The MTT assay indicated that sBV treatment exhibited a growth inhibitory effect at a concentration over 5 µg/mL. On fluorescence activated cell sorting analysis, G0 dead cells were observed after G1 arrest at treatment concentrations up to 10 µg/mL. However, rapid cell rupture was observed at a concentration of 20 µg/mL. Western blot analysis demonstrated that sBV treatment modulated the expression of multiple cell death-related proteins, including cleaved-PARP, cleaved-caspase 9, p53, Bcl2, and Bax. Conclusion: sBV induced cell death in A549 human lung cancer cells at a pharmacological concentration, albeit causing hemolytic cell death at a high concentration.

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Melittin and Breast Cancer: A Brief Review of the Evidence

Cited by 3 publications

References 0 publications

An Updated Review Summarizing the Anticancer Efficacy of Melittin from Bee Venom in Several Models of Human Cancers

An Updated Review Summarizing the Anticancer Efficacy of Melittin from Bee Venom in Several Models of Human Cancers

Potential of Melittin to induce apoptosis and overcome multidrug resistance in human colon cancer cell line

Dual Cytotoxic Responses Induced by Treatment of A549 Human Lung Cancer Cells with Sweet Bee Venom in a Dose-Dependent Manner

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