Membrane fixation enhances guided bone regeneration in standardized calvarial defects: A pre‐clinical study

An, Yin-Zhe; Strauß, Franz Josef; Park, Jin‐Young; Shen, Yu Qin; Thoma, Daniel S.; Lee, Jung Seok

doi:10.1111/jcpe.13583

Cited by 20 publications

(18 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To circumvent this problem, techniques to immobilize the collagen membrane have been used, including membrane‐stabilizing sutures, bone tacks, and titanium pins (Porcaro et al, 2017). Membrane fixation using bone tacks has been shown to enhance not only the width of the sites grafted with particulate bone substitute (Mir‐Mari et al, 2016; Naenni, Berner, et al, 2019) but also the expression of osteogenic factors (An et al, 2021). These bone tacks, however, can increase the duration of surgery, cost of treatment, and difficulty of the augmentation procedure.…”

Section: Introductionmentioning

confidence: 99%

Effect of collagen membrane fixation on ridge volume stability and new bone formation following guided bone regeneration

Park

Song

et al. 2022

J Clinic Periodontology

Self Cite

View full text Add to dashboard Cite

Aim To test the effect of membrane fixation on ridge volume stability and new bone formation using guided bone regeneration. Materials and Methods In eight beagle dogs, after bilateral extraction of the maxillary pre‐molars, a box‐shaped defect was created on each side. All defect sites were augmented with a particulate bone substitute material, covered with either one of two non‐cross‐linked collagen membranes (CM1 or CM2) with or without fixation (‐F or ‐UF). Samples were collected after 8 weeks. Histomorphometric and micro‐computed tomography analyses were performed. Results Membrane fixation made no significant difference to the total augmented volume for both membranes (p > .05). Histological data indicated that at the ridge crest the augmented tissue width amounted to 2.4 ± 0.4 mm in the group CM1‐F and 2.4 ± 0.5 mm in the group CM1‐UF, with no significant difference between the groups. Conversely, in CM2‐F the augmented tissue width was significantly larger than in CM2‐UF (2.3 ± 0.1 vs. 1.57 ± 0.27, p < .05). Conclusions Membrane fixation in contained defects failed to improve ridge volume stability regardless of the membrane type. However, it may enhance the width of the augmented ridge at the coronal portion depending on the type of membrane.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of collagen membrane fixation on ridge volume stability and new bone formation following guided bone regeneration

Park

Song

et al. 2022

J Clinic Periodontology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Том 21 № 3. 2022 Таким образом, результаты исследования, полученные авторами через 12 месяцев после оперативного лечения, позволяют обоснованно присоединиться к мнению отечественных и зарубежных коллег, использующих дополнительную фиксацию пародонтологической мембраны пинами, особенно, как представлено в данном исследовании, при дефектах сложной конфигурации [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30].…”

Section: For Citationunclassified

Analysis of wound discharge microbiota in patients with drug-associated osteonecrosis of the jaw

Konovalova

Ivanov

Zyul'kina

et al. 2022

jour

View full text Add to dashboard Cite

Introduction. Chronic forms of inflammatory periodontal diseases, leading to deterioration of bone tissue quality and volume, are the most important and urgent problems for modern dentistry. Despite the measures taken at different levels of prevention the tendency to the increase of patients with periodontitis has been revealed. The aim of the investigation was to make a comparative clinical and radiological evaluation of the effectiveness of directed tissue regeneration (DTR) using different methods of membrane placement in the area of defects with complex configuration in patients with moderate-to-severe chronic periodontitis. Material and methods. Patients were divided into two groups of 30 patients each. Study design: open randomized. Patients of the first group were operated on using DTR technique and additional membrane fixation by means of periodontal micropins; patients of the second group were operated on using DTR without additional membrane fixation. The results were assessed by clinical and radiological examination after 1, 3, 6 and 12 months. Results. More active regenerative processes were registered in the first group; the periodontal pocket depth after one month was 2,77 ± 0,08 mm, in patients of the second group – 2,85 ± 0,03 mm (p < 0,05); the tendency for decrease of this index remained during all investigation. The Hounsfield index after 12 months was 1658 ± 45.38 units in the first group and 1589 ± 12.02 units in the second group (p < 0.05). Discussion. When comparing the obtained data with those of their foreign colleagues, the authors concluded that additional fixation of the membrane leads to a less pronounced deformation and preservation of the bone volume in the long-term postoperative period. Conclusion. The use of micropins for membrane fixation allows to work with defects of complex configuration and in the long term leads to formation of denser bone tissue with preservation of its volume.

show abstract

“…Up to now, collagen membrane is the one of favorable barrier materials used in GTR operation, as removal surgery and additional pain or infection are associated with the other non-resorbable membranes [14,15]. However, the reconstruction outcomes are significantly depended on the stability of collagen membrane and regeneration space [16][17][18]. Hence, the barrier membrane is frequently used combined with bone grafts, as such bone Conclusions: Our results suggested that such modularized hierarchical architectures have excellent potential as a next-generation oral implants, and this precisely tuned guided tissue regeneration route offer an opportunity for improving periodontal damage reconstruction and reducing operation sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Modularized bioceramic scaffold/hydrogel membrane hierarchical architecture beneficial for periodontal tissue regeneration in dogs

et al. 2022

View full text Add to dashboard Cite

Background Destruction of alveolar bone and periodontal ligament due to periodontal disease often requires surgical treatment to reconstruct the biological construction and functions of periodontium. Despite significant advances in dental implants in the past two decades, it remains a major challenge to adapt bone grafts and barrier membrane in surgery due to the complicated anatomy of tooth and defect contours. Herein, we developed a novel biphasic hierarchical architecture with modularized functions and shape based on alveolar bone anatomy to achieve the ideal outcomes. Methods The integrated hierarchical architecture comprising of nonstoichiometric wollastonite (nCSi) scaffolds and gelatin methacrylate/silanized hydroxypropyl methylcellulose (GelMA/Si-HPMC) hydrogel membrane was fabricated by digital light processing (DLP) and photo-crosslinked hydrogel injection technique respectively. The rheological parameters, mechanical properties and degradation rates of composite hydrogels were investigated. L-929 cells were cultured on the hydrogel samples to evaluate biocompatibility and cell barrier effect. Cell scratch assay, alkaline phosphatase (ALP) staining, and alizarin red (AR) staining were used to reveal the migration and osteogenic ability of hydrogel membrane based on mouse mandible-derived osteoblasts (MOBs). Subsequently, a critical-size one-wall periodontal defect model in dogs was prepared to evaluate the periodontal tissue reconstruction potential of the biphasic hierarchical architecture. Results The personalized hydrogel membrane integrating tightly with the nCSi scaffolds exhibited favorable cell viability and osteogenic ability in vitro, while the scratch assay showed that osteoblast migration was drastically correlated with Si-HPMC content in the composite hydrogel. The equivalent composite hydrogel has proven good physiochemical properties, and its membrane exhibited potent occlusive effect in vivo; meanwhile, the hierarchical architectures exerted a strong periodontal regeneration capability in the periodontal intrabony defect models of dogs. Histological examination showed effective bone and periodontal ligament regeneration in the biomimetic architecture system; however, soft tissue invasion was observed in the control group. Conclusions Our results suggested that such modularized hierarchical architectures have excellent potential as a next-generation oral implants, and this precisely tuned guided tissue regeneration route offer an opportunity for improving periodontal damage reconstruction and reducing operation sensitivity. Graphical Abstract

show abstract

Membrane fixation enhances guided bone regeneration in standardized calvarial defects: A pre‐clinical study

Cited by 20 publications

References 30 publications

Effect of collagen membrane fixation on ridge volume stability and new bone formation following guided bone regeneration

Effect of collagen membrane fixation on ridge volume stability and new bone formation following guided bone regeneration

Analysis of wound discharge microbiota in patients with drug-associated osteonecrosis of the jaw

Modularized bioceramic scaffold/hydrogel membrane hierarchical architecture beneficial for periodontal tissue regeneration in dogs

Contact Info

Product

Resources

About