Memory rehabilitation for people with multiple sclerosis

Taylor, Lauren; Mhizha-Murira, Jacqueline R; Smith, Laura; Potter, Kristy-Jane; Wong, Dana; Evangelou, Nikos; Lincoln, Nadina B.; Nair, Roshan das

doi:10.1002/14651858.cd008754.pub4

Cited by 31 publications

(19 citation statements)

References 158 publications

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“…The treatment of cognitive impairment in MS is an important unmet need. While cognitive rehabilitation has been proven to be effective in improving cognitive performance in MS [7][8][9], studies with larger sample sizes, inclusion of patients with progressive disease, assessment of the effects on daily life and long-term follow-up data are still lacking [6]. Furthermore, research in the elderly indicates that combined cognitive-motor rehabilitation may be more effective than single cognitive or motor training [23].…”

Section: Discussionmentioning

confidence: 99%

“…Some aspects of the trial need clarification. First, we have chosen not to include a passive control group, since the effectiveness of cognitive rehabilitation in multiple sclerosis has already been proven [7][8][9], and the goal of this study is to evaluate whether a combined cognitive-motor training is more effective than single cognitive or motor training in improving cognitive performance. Second, our primary outcome measure is the digit span backwards, a measure of working memory, since the cognitive part of our training programme is focused on working memory improvement and studies have shown that improvement of cognitive performance seems to be limited to the functions that were trained [23].…”

Section: Discussionmentioning

confidence: 99%

“…Its management is an important gap in the treatment of MS [6]. Cognitive rehabilitation is the most promising treatment strategy [6], with recent meta-analyses finding conclusive evidence that both cognitive rehabilitation interventions in general and memory rehabilitation improve objective cognitive performance [7][8][9]. However, many challenges remain that hamper implementation into daily practice; studies with larger sample sizes, inclusion of patients with progressive disease, assessment of the effects on daily life and long-term follow-up data are still lacking [6].…”

Section: Introductionmentioning

confidence: 99%

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Cognitive-motor telerehabilitation in multiple sclerosis (CoMoTeMS): study protocol for a randomised controlled trial

Laethem

Steen

Kos

et al. 2022

Trials

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Background The management of cognitive impairment is an important goal in the treatment of multiple sclerosis (MS). While cognitive rehabilitation has been proven to be effective in improving cognitive performance in MS, research in the elderly indicates a higher effectiveness of combined cognitive-motor rehabilitation. Here, we present the protocol of a randomised controlled clinical trial to assess whether a combined cognitive-motor telerehabilitation programme is more effective in improving working memory than only cognitive or motor training. Methods/design The CoMoTeMS-trial is a two-centre, randomised, controlled and blinded clinical trial. A total of 90 patients with MS will receive 12 weeks of either a combined cognitive-motor telerehabilitation programme or only cognitive or motor training. The primary outcome is a change in the digit span backwards. Secondary outcomes are other cognitive changes (Brief International Cognitive Assessment for Multiple Sclerosis and Backward Corsi), Expanded Disability Status Scale (EDSS), 6-Min Walk Test, 25-Foot Walk Test, 9-Hole Peg Test, anxiety and depression, fatigue, quality of life, cognitive and physical activity level, electroencephalography and magnetic resonance imaging of the brain. Discussion We hypothesise that the improvement in digit span backwards after 12 weeks of treatment will be significantly higher in the group treated with the combined cognitive-motor telerehabilitation programme, compared to the groups receiving only cognitive and only motor training. Trial registration ClinicalTrials.gov NCT05355389. Registered on 2 May 2022.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cognitive-motor telerehabilitation in multiple sclerosis (CoMoTeMS): study protocol for a randomised controlled trial

Laethem

Steen

Kos

et al. 2022

Trials

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“…5,6,27,28 For example, a recent Cochrane Review of 44 memory rehabilitation interventions evaluated in randomised controlled trials in MS found that patients who received memory rehabilitation reported better memory functioning and quality of life relative to those who did not receive memory rehabilitation. 29 A number of recent clinical reviews and guidelines about cognitive rehabilitation in MS are available that can be used to guide care and treatment planning. 4,6,7,10 It is important to note that other 'invisible' MS symptoms (eg fatigue, depression, pain, sleep difficulties) can have an adverse impact on cognitive functioning and therefore may need to be addressed to optimise the outcome of targeted cognitive rehabilitation interventions.…”

Section: Next Steps: Choosing Between the Effective Cognitive Rehabil...mentioning

confidence: 99%

Cognitive rehabilitation in multiple sclerosis

Longley¹

2022

Aust J Gen Pract

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“…(19) In relation to memory-related interventions (activities necessary to improve patient independence and performance of daily activities), 44 studies of a total of 2714 patients found that memory rehabilitation improved functioning and quality of life, although there was no effect in relation to improvement in activities of daily living or decreased anxiety. (20)…”

Section: Multiple Sclerosis Drug Analysismentioning

confidence: 99%

Multiple Sclerosis. A Scientific Review From 2016 to 2022

García¹,

Belesaca²,

Peláez³

et al. 2022

EPRA

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Multiple sclerosis is a disease that is characterized by the nervous system injury. The pathophysiology is unknown, but it is supposed that it is caused by an increase of the immune response to the myelin sheath, which causes damage in the nervous system. Actually, there are a lot of immunomodulatory drugs to control this pathology. One of the most important aspects of this disease is the fact that it is irreversible; therefore, the use of drugs for this illness is just for the control of the symptoms; nevertheless, some review has shown the free-recurrency of multiple sclerosis. Nowaday, there is information that defines the effectiveness of Rituximab, Alemtuzumab, Fingolimod, and many more drugs. In the non-pharmacological aspects, there is information about the diet and its non-action in the progression of Multiple Sclerosis. When a patient presents fatigue, there are many alternatives for the control of this. Finally, activities which stimulate social interactions have shown little effectiveness in these patients. KEYWORDS: Multiple Sclerosis,Nervous System,Immune Syste

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Memory rehabilitation for people with multiple sclerosis

Abstract: Memory rehabilitation for people with multiple sclerosis.

Cited by 31 publications

References 158 publications

Cognitive-motor telerehabilitation in multiple sclerosis (CoMoTeMS): study protocol for a randomised controlled trial

Cognitive-motor telerehabilitation in multiple sclerosis (CoMoTeMS): study protocol for a randomised controlled trial

Cognitive rehabilitation in multiple sclerosis

Multiple Sclerosis. A Scientific Review From 2016 to 2022

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