Menge und Zusammensetzung der Hautoberfl�chenlipide bei Patienten mit Acne vulgaris und gesunden Vergleichspersonen

Gloor, M.; U, Graumann; Kionke, M.; Wiegand, Iris; Friederich, H. C.

doi:10.1007/bf00595417

Cited by 31 publications

(4 citation statements)

References 19 publications

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“…So far, no anatomical features of the epidermis or pilosebaceous apparatus have been xmcovered to explain the development of this disease. However, some differences in functional parameters, such as increased sebum excretion in acne subjects, have been described by several investigators (Cotterill et al, 1971;Cunliffe et al, 1972;Cunliffe & Shuster, 1969a, b;Gloor et al, 1972;Pochi & Strauss, 1954;Powell & Beveridge, 1970;Strauss & Pochi, 1961). The reasons for this augmented lipid production and its role in the aetiopathogenesis of acne vulgaris are unknown.…”

Section: Discussionmentioning

confidence: 99%

Acne vulgaris: proliferative cells in sebaceous glands

Plewig¹

1974

Br J Dermatol

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SUMMARY The proliferative activity of sebaceous glands of uninvolved skin from acne patients was analysed by means of 3H‐thymidine autoradiography and by planimetry. Twelve specimens of normal skin from the back (with thirty‐five glands) and two specimens from the face (with six glands) were analysed. Labelling indices and planimetric values were determined separately for the two portions within each gland: the differentiating cell pool with germinative cells and large lipid cells; and the undiffer‐entiated cell pool with multilayered cells. The germinative cells of the differentiating cell pool on the back and face of patients with acne showed a significantly greater labelling index than in control subjects. The undifferentiated cell pool, although having a higher labelling index than the differentiating cell pool, was similar both in acne patients and in controls. Planimetry confirmed that the sebaceous glands of patients are much larger than those of normal subjects. Therefore, the known increase in sebum excretion in acne patients is a result of two factors—an increase in lipid cell production and an increase in sebaceous gland size.

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Section: Discussionmentioning

confidence: 99%

Acne vulgaris: proliferative cells in sebaceous glands

Plewig¹

1974

Br J Dermatol

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“…We thought it more meaningful to measure sebum excretion rate on the forehead and our results do not support the observations of Rajka of a greatly decreased sebum excretion rate in people with constitutional eczema. There is an almost undisputed link between the degree of acne and seborrhoea, with control subjects having a low rate of sebum production (Pochi & Strauss, 1964;Cimliffe & Shuster, 1969;Gloor et al, 1972). The low sebum excretion in patients with constitutional eczema is thus one reason for the low incidence of acne in such subjects.…”

Section: Discussionmentioning

confidence: 99%

Sebum excretion rate, surface lipid composition and constitutional eczema

1977

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“…There has been considerable research regarding skin lipidomics in patients with SD. In older studies from many years ago, patients with SD were discovered to have decreased squalene, free fatty acids, and wax esters, as well as elevated levels of cholesterol, triglycerides, and paraffins [ 62 ]. Similar results were obtained by Passi et al, who studied patients with SD who were HIV-negative; patients had significantly higher content of cholesterol within the skin lesions, a lower level of squalene, and lower total lipid capacity compared to controls without SD [ 63 ].…”

Section: Seborrhoeic Dermatitismentioning

confidence: 99%

Lipid Alterations and Metabolism Disturbances in Selected Inflammatory Skin Diseases

Nowowiejska

Baran

Flisiak

2023

IJMS

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Lipidomics is a term used to define the field that analyzes the structure, functions, and interactions of lipids. Inflammatory dermatoses and lipid disturbances are interrelated, especially due to chronic inflammatory conditions. This review discusses lipidomics in selected inflammatory skin diseases: psoriasis, lichen planus, and atopic dermatitis, as well as the less commonly mentioned hidradenitis suppurativa, rosacea, and acne vulgaris. Lipid homeostasis disorders are common; they are especially well-documented in psoriasis, lichen planus, and atopic dermatitis. Future studies are required for better insight into this issue, particularly on the skin lipidome. Understanding lipidomics, in particular skin diseases, increases our knowledge about their pathogenesis, and may become useful in adjusting tailored management for each patient as well establishing prognosis. Noteworthily, it seems advisable to alert doctors to the need to analyze lipid parameters and the complications of abnormal lipid metabolism in dermatological patients, which could decrease their comorbidities and improve the life quality and health condition of dermatological patients.

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Menge und Zusammensetzung der Hautoberfl�chenlipide bei Patienten mit Acne vulgaris und gesunden Vergleichspersonen

Cited by 31 publications

References 19 publications

Acne vulgaris: proliferative cells in sebaceous glands

Acne vulgaris: proliferative cells in sebaceous glands

Sebum excretion rate, surface lipid composition and constitutional eczema

Lipid Alterations and Metabolism Disturbances in Selected Inflammatory Skin Diseases

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