Meningeal involvement by a transformed mycosis fungoides following Hodgkin's disease

Beylot‐Barry, M.; Dubus, Pierre; Vergier, Béatrice; Cogrel, O.; Marit, Gérald; Beylot, C; Merlio, Jean Philippe

doi:10.1046/j.1365-2133.1999.03168.x

Cited by 10 publications

(14 citation statements)

References 25 publications

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“…All patients with stage III or IV MF/SS were erythrodermic, except 1 patient with stage IVB MF because of meningeal involvement, as reported elsewhere. 26 Patients with stage IA to IIA MF were considered as having early-stage MF/SS, and patients with stage IIB to IVB MF and patients with SS were considered as having advanced-stage MF/SS.…”

Section: Resultsmentioning

confidence: 99%

Bone Marrow Histopathologic and Molecular Staging in Epidermotropic T-Cell Lymphomas

et al. 2003

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This study was undertaken to determine the prognostic value of bone marrow histopathologic and molecular analyses in 53 patients with mycosis fungoides and 7 with Sézary syndrome. Bone marrow was involved in only 1 patient with Sézary syndrome, clinical stage IVA, before bone marrow biopsy. An ambiguous T-cell infiltrate was observed in 8 patients but was not associated with disease progression. The bone marrow specimen was normal in 51 patients. Monoclonality was detected in the skin specimen in 44 cases; an identical T-cell clone in the blood specimen was found in 21 of them and, in 16 of the 21 patients, in bone marrow specimens without histologic correlation. Multivariate analysis confirmed that clinical stage and detection by polymerase chain reaction of an identical T-cell clone in skin and blood specimens had an independent prognostic value. No further prognostic value was observed for the presence of a T-cell clone in bone marrow specimens. Our data do not support the need for bone marrow examination in patients with mycosis fungoides/Sézary syndrome.

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Section: Resultsmentioning

confidence: 99%

Bone Marrow Histopathologic and Molecular Staging in Epidermotropic T-Cell Lymphomas

et al. 2003

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“…A literature search revealed only 5 Tables III and IV. 5,[7][8][9][10] It is important to note that brain biopsy was not performed to confirm the histologic presence of LCT in CNS, but MF was confirmed in the periphery and imaging obtained after CNS symptoms strongly suggested MF spread to the CNS. In 4 of our 5 patients, eye biopsies were performed; 3 specimens were positive.…”

Section: Discussionmentioning

confidence: 97%

Central nervous system involvement in patients with mycosis fungoides and cutaneous large-cell transformation

Duvic

2008

Journal of the American Academy of Dermatology

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“…the other hand, it is well known that patients with HL are at increased risk of developing second malignant neoplasms including non-Hodgkin's iymphoma (4)(5)(6). Occurrence of MF in patients with previous HL has also been reported occasionally (7).…”

Section: Discussionmentioning

confidence: 98%

Mycosis Fungoides with Recurrent Hodgkin’s Lymphoma and Diffuse Large B-cell Lymphoma

Miyagaki¹,

Sugaya²,

Minatani³

et al. 2009

Acta Derm Venerol

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SinMycosis fungoides (MF), a common form of primary ctitaneous T-cell lymphoma (CTCL), is a type of to nonHodgkin's lymphoma (HL). Although the coexistence of multiple distinct lymphoid neoplasms in the same itidividual is rare, cases of CTCL associated with HL or other types of non-Hodgkin's lymphoma have been described previously (1-3). We report here a rare case of MF associated with a composite recurrent HL and diffuse large B-cell lymphoma (DLBCL). CASE REPORTiA 75-year-oid Japatiese man was referred to our hospital with scaly erythematous plaques distributed over most of his body. The patient had a histoiy of nodular-sclerosing subtype HL diagnosed at the age of62 years with persistent fever and left axillary lymph node swelling. Biopsy specimens from axillary lymph nodes showed a pleomorphic cellular infiltróte with bands of fibrosis and contained nunieroiis large atypicul cells, including ReedStemberg cells and lacunar cells {Fig. la). Immunohistochemistry and in situ hybridization showed thai the Reed-Stcmbcrg cells were positive for CD30 and Epstein-Barr vims-encoded RNA (EBER) and negative for CD20. In addition. T-cell markers were negative. These features confirmed the diagnosis of nodularsclerosis subtype of HL. He was treated with polychemotherapy (cyclophosphamide, vincristine, procarbazine and prednisolone) combined with radiation therapy and complete remission was achieved. Mis medical history was otherwise unremarkable.At presentation, scaly erythematous patches and infiltrated plaques were distributed over most of ihe patient's body (Fig. 2a). The skin lesions had initially appeared at the age of 64 years on his left arm and the number of lesions increased year after year. He had no lymphadenopathy. Hislological examination of a skin biopsy specimen from the left shoulder revealed infiltration of small lymphocytes with only subtle nuclear atypia in the epidermis and superficial dennis (Fig. 2b). Immunohistochemieal study showed that these atypical cells were positive forCD3 and CD4., bul negative for CD20 and CD30. Southern blotting analysis of T-cell receptor gene using DNA from lesional skin detected a monoclonal rearrangement band. Further detailed examination revealed no visceral, lymph node, or blood involvement. The patient was diagnosed with MF. T2bNOMOIîO, clinical stage Ib.The skin lesions were treated with oral psoralen-ultraviolet A (PUVA) therapy and topical corticosteroid. resulting in partial improvement. The skin lesions remained stable thereafter. Three years after the diagnosis of MF. a subcutaneous mass (3.5x3.0 cm) appeared on the patient's left lower abdomen. He also developed swelling of multiple lymph nodes, ranging from the aortic bifurcation region to the bilateral inguinal region. Biop.sy specimens from the inguinal lymph nodes showed almost the same pathological findings as those from axillary lymph nodes at the age of 62 years (Fig. Ib). In addition, there was a lesion composed of diffuse infiltration of large-sized centroblasts(FÍg. le). Most large atypical lymphocyt...

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Meningeal involvement by a transformed mycosis fungoides following Hodgkin's disease

Cited by 10 publications

References 25 publications

Bone Marrow Histopathologic and Molecular Staging in Epidermotropic T-Cell Lymphomas

Bone Marrow Histopathologic and Molecular Staging in Epidermotropic T-Cell Lymphomas

Central nervous system involvement in patients with mycosis fungoides and cutaneous large-cell transformation

Mycosis Fungoides with Recurrent Hodgkin’s Lymphoma and Diffuse Large B-cell Lymphoma

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