Menopausal changes in calcium balance performance

Heaney, Robert P.; Recker, Robert R.; Saville, Paul D.

doi:10.1111/j.1753-4887.1983.tb07709.x

Cited by 98 publications

(58 citation statements)

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“…It is likely that the RYR3 A→G polymorphism may regulate the intracellular Ca 2+ concentration and increase susceptibility to breast cancer. The increased risk associated with this genetic variant in postmenopausal women is consistent with the knowledge that estrogens are regulators of calcium influx (29) and that postmenopausal women absorb calcium less efficiently (30,31). It has been postulated that microcalcification is a result of abnormal calcium deposition and mineralization of necrotic debris (32,33).…”

Section: Discussionsupporting

confidence: 65%

Functional SNP in the microRNA-367 binding site in the 3′UTR of the calcium channel ryanodine receptor gene 3 ( RYR3 ) affects breast cancer risk and calcification

Zhang

Liu

Song

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

145

106

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We have evaluated and provided evidence that the ryanodine receptor 3 gene (RYR3), which encodes a large protein that forms a calcium channel, is important for the growth, morphology, and migration of breast cancer cells. A putative binding site for microRNA-367 (miR-367) exists in the 3′UTR of RYR3, and a genetic variant, rs1044129 A→G, is present in this binding region. We confirmed that miR-367 regulates the expression of a reporter gene driven by the RYR3 3′UTR and that the regulation was affected by the RYR3 genotype. A thermodynamic model based on base pairing and the secondary structure of the RYR3 mRNA and miR-367 miRNA showed that miR-367 had a higher binding affinity for the A genotype than for the G genotype. The rs1044129 SNP was genotyped in 1,532 breast cancer cases and 1,600 healthy Chinese women. The results showed that compared with the AA genotype, G was a risk genotype for breast cancer development and was also associated with breast cancer calcification and poor survival. Thus, rs1044129 is a unique SNP that resides in a miRNA-gene regulatory loop that affects breast cancer risk, calcification, and survival.

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Section: Discussionsupporting

confidence: 65%

Functional SNP in the microRNA-367 binding site in the 3′UTR of the calcium channel ryanodine receptor gene 3 ( RYR3 ) affects breast cancer risk and calcification

Zhang

Liu

Song

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

145

106

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“…Heaney and colleagues published a series of influential calcium balance studies, concluding that premenopausal women required 1000-1200 mg/day and post-menopausal women 1500 mg/day to maintain neutral calcium balance (83,84). Small increases in bone density were reported in randomised controlled trials (RCTs) of calcium supplements with or without vitamin D (85,86).…”

Section: Brief History Of Calcium Intake Recommendationsmentioning

confidence: 99%

Calcium supplementation in osteoporosis: useful or harmful?

Chiodini

Bolland

2018

European Journal of Endocrinology

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Osteoporosis and fragility fractures are important social and economic problems worldwide and are due to both the loss of bone mineral density and sarcopenia. Indeed, fragility fractures are associated with increased disability, morbidity and mortality.It is known that a normal calcium balance together with a normal vitamin D status is important for maintaining well-balanced bone metabolism and for many years calcium and vitamin D has been considered crucial in the prevention and treatment of osteoporosis. However, recently the usefulness of calcium supplementation (alone or with concomitant vitamin D) has been questioned, since some studies reported only weak efficacy of these supplementations in reducing fragility fracture risk. On the other hand, besides the gastrointestinal side effects of calcium supplements and the risk of kidney stones related to use of coadministered calcium and vitamin D supplements, other recent data suggested potential adverse cardiovascular effects from calcium supplementation.This debate article is focused on the evidence regarding both the possible usefulness for bone health and the potential harmful effects of calcium and/or calcium with vitamin D supplementation.

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“…The Recommended Dietary Allowance (RDA) for European adults is 800 mg/d (6) . After menopause, Ca requirements increase to at least 1000 mg/d (7,8) .…”

mentioning

confidence: 99%

Low dietary calcium in European postmenopausal osteoporotic women

Bruyère

Cock

Mottet

et al. 2009

Public Health Nutr.

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Objective: The WHO recommends a daily Ca intake for postmenopausal women of 1300 mg. The objective of the present study was to assess the dietary Ca intake in European postmenopausal osteoporotic women. Design, setting and subjects: Assessment of dietary Ca intake (food and supplements) was performed with a validated self-questionnaire in 8524 osteoporotic women from nine European countries (Belgium, Denmark, France, Germany, Hungary, Italy, Poland, Spain and the UK).

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Menopausal changes in calcium balance performance

Abstract: Editor's Note: This paper is one of the first suggesting that idiapathic osteoporosis may be n disorder of calcium metabolism for which increased intakes calcium mas be preventative.

Cited by 98 publications

References 0 publications

Functional SNP in the microRNA-367 binding site in the 3′UTR of the calcium channel ryanodine receptor gene 3 ( RYR3 ) affects breast cancer risk and calcification

Functional SNP in the microRNA-367 binding site in the 3′UTR of the calcium channel ryanodine receptor gene 3 ( RYR3 ) affects breast cancer risk and calcification

Calcium supplementation in osteoporosis: useful or harmful?

Low dietary calcium in European postmenopausal osteoporotic women

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