Menopause and its effect on the female lower urinary tract

Henn, Etienne W

doi:10.1080/20786204.2010.10874015

Cited by 4 publications

(4 citation statements)

References 30 publications

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“…Many aspects of somatic aging in Western women have been linked with this drop (e.g., Riggs et al, 1998; Pfeilschifter et al, 1978; Turgeon et al, 2006; Stevenson and Thornton, 2007; Wise et al, 2009; Gibbs, 2010; Henn, 2010). Yet postmenopausal declines in physiological competence are not large enough to cause an inflection in mortality (Hamilton, 1966; Gavrilov and Gavrilova, 1991) or stop postmenopausal women from continuing high levels of economic productivity (e.g., Hawkes et al, 1989, 1997).…”

mentioning

confidence: 99%

“…When follicle stocks fall below a threshold needed to support ovulation, cycling stops (Faddy and Gosden, 1996;McGee and Hsueh, 2000) and, estrogen secretion plummets to levels so low that it remains controversial whether postmenopausal ovaries produce any (Labrie et al, 2011). Many aspects of somatic aging in Western women have been linked with this drop (e.g., Riggs et al, 1998;Pfeilschifter et al, 1978;Turgeon et al, 2006;Stevenson and Thornton, 2007;Wise et al, 2009;Gibbs, 2010;Henn, 2010). Yet postmenopausal declines in physiological competence are not large enough to cause an inflection in mortality (Hamilton, 1966;Gavrilov and Gavrilova, 1991) or stop postmenopausal women from continuing high levels of economic productivity (e.g., Hawkes et al, 1989Hawkes et al, , 1997.…”

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confidence: 99%

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Brief communication: Adrenal androgens and aging: Female chimpanzees (Pan troglodytes) compared with women

Blevins

Coxworth

Herndon

et al. 2013

American J Phys Anthropol

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Ovarian cycling continues to similar ages in women and chimpanzees yet our nearest living cousins become decrepit during their fertile years and rarely outlive them. Given the importance of estrogen in maintaining physiological systems aside from fertility, similar ovarian aging in humans and chimpanzees combined with somatic aging differences indicates an important role for nonovarian estrogen. Consistent with this framework, researchers have nominated the adrenal androgen dehydroepiandrosterone (DHEA) and its sulfate (DHEAS), which can be peripherally converted to estrogen, as a biomarker of aging in humans and other primates. Faster decline in production of this steroid with age in chimpanzees could help explain somatic aging differences. Here, we report circulating levels of DHEAS in captive female chimpanzees and compare them with published levels in women. Instead of faster, the decline is slower in chimpanzees, but from a much lower peak. Levels reported for other great apes are lower still. These results point away from slowed decline but toward increased DHEAS production as one of the mechanisms underlying the evolution of human longevity.

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confidence: 99%

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confidence: 99%

Brief communication: Adrenal androgens and aging: Female chimpanzees (Pan troglodytes) compared with women

Blevins

Coxworth

Herndon

et al. 2013

American J Phys Anthropol

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“… 17 In the present study, almost half of the postmenopausal women with GSM had urinary symptoms, with 137 (48.1%) suffering from dysuria and 156 (54.7%) having urinary frequency/urgency. Two-thirds of women do not relate their vaginal or urinary complaints to menopause, 18 and they often delay seeking treatment for several years as these symptoms are more often taken as part of aging.…”

Section: Discussionmentioning

confidence: 99%

Genitourinary Syndrome of Menopause among Postmenopausal Women in a Tertiary Care Centre: A Descriptive Cross-sectional Study

Ojha¹,

Bista²,

Bajracharya³

et al. 2022

J Nepal Med Assoc

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Introduction: Genitourinary syndrome of menopause incorporates vulvovaginal and lower urinary tract symptoms related to estrogen deficiency which affects more than half of postmenopausal women. This study aimed to find out the prevalence of genitourinary syndrome of menopause among postmenopausal women attending a tertiary care center. Methods: A descriptive cross-sectional study was conducted at the Department of Obstetrics and Gynaecology of tertiary care hospital from October 2019 to April 2021 after obtaining ethical approval from the Institutional Review Committee (Reference number: 452 6-11). A convenience sampling method was used among postmenopausal women aged 40-75 years attending gynaecology outpatient departments. The information was obtained by interview and examination. Analysis was done using the Statistical Package for the Social Sciences version 20. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data. Results: Among the 385 postmenopausal women, 285 (74.02%) (69.63-78.40 at 95% Confidence Interval) had a diagnosis of genitourinary syndrome of menopause. The mean age of menopause was 48.2±3.6years. The most common symptom and sign were vaginal dryness in 223 (78.2%) and decreased moisture 200 (70.2%). Regarding the impact of genitourinary syndrome of menopause on quality of life, it least affected the activities of daily living and mostly on sexual functioning. Conclusions: The study showed three-fourth of postmenopausal women suffered from genitourinary syndrome of menopause which is similar to the previous studies done in other countries, in postmenopausal women. Therefore, understanding genitourinary syndrome of menopause is vital, and assuring women those treatments are available to relieve symptoms may improve their quality of life.

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“…With menopause, there is a significant fall in the level of estrogen and hence the impact on all estrogen-sensitive tissues. [ 1 ] There are both histological and functional changes associated with menopause due to the falling levels of circulating estrogen, both in the genital tract as well as the lower urinary tract. [ 2 ]…”

Section: Introductionmentioning

confidence: 99%

Is urodynamic study is a necessity for evaluation of lower urinary tract symptoms in postmenopausal female patients? Result of a prospective observational study

et al. 2017

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Aim:The aim of this study is to evaluate the causes of lower urinary tract symptoms (LUTS) in postmenopausal female patients (PMFP) and correlate their symptoms with their urodynamic study (UDS) findings.Materials and Methods:A prospective observational study analyzing the clinical and UDS findings of PMFP presenting with LUTS. A detailed history including history of diabetes, neurological disease, drug history, and pelvic surgeries was taken, followed by physical examination and urodynamic assessment.Results:A total of 100 patients were classified according to their predominant symptoms into three categories: (1) voiding dysfunction (45 patients), (2) storage symptoms (30 patients), and (3) urinary incontinence (25 patients). The patients with voiding LUTS could be categorized urodynamically into three grades of bladder outlet obstruction (BOO): (a) early (37.8%) (maximal flow [Qmax] >15 mL/s and detrusor pressure at maximal flow [PdetQmax] >30 cm of water), (b) compensated (31.1%) (Qmax <15 mL/s and PdetQmax >30 cm of water), and (c) late (31.1%) (Qmax <15 mL/s and PdetQmax <30 cm of water). The patients with storage symptoms could be categorized into two with either the presence of demonstrable idiopathic detrusor contractions (53.3%) or not (46.7%). The patients with incontinence were of three types: (a) stress incontinence (44%), (b) urge incontinence (28%), and (c) mixed incontinence (28%). UDS showed no demonstrable leak in nine patients (36%) and the rest had UDS findings corroborative to their symptoms.Conclusions:Thus, the major LUTS in PMFP were BOO, storage symptoms, and incontinence. Proper evaluation of LUTS necessitates UDS and along with good physical examination can help us in reaching a correct diagnosis and plan respective treatment.

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Menopause and its effect on the female lower urinary tract

Cited by 4 publications

References 30 publications

Brief communication: Adrenal androgens and aging: Female chimpanzees (Pan troglodytes) compared with women

Brief communication: Adrenal androgens and aging: Female chimpanzees (Pan troglodytes) compared with women

Genitourinary Syndrome of Menopause among Postmenopausal Women in a Tertiary Care Centre: A Descriptive Cross-sectional Study

Is urodynamic study is a necessity for evaluation of lower urinary tract symptoms in postmenopausal female patients? Result of a prospective observational study

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