Mentha rotundifolia (L.) Huds. aqueous extract attenuates H2O2 induced oxidative stress and neurotoxicity

Abstract

IntroductionOxidative stress plays a causal role in neurodegenerative diseases. The aim of this study is to evaluate the antioxidant and neuroprotective effects of Mentha rotundifolia (L.) Huds (M. rotundifolia), a widely used Moroccan plant in traditional medicine.MethodsThe chemical composition of M. rotundifolia aqueous extract was analyzed by liquid chromatography coupled to mass spectrometry (LC-MS). 2,2-diphenyl 1-picrylhydrazyl (DPPH) and 2,2′-azino-bis 3-ethylbenzothiazoline-6-sulfonic acid (ABTS+) assays were used to assess its in vitro antioxidant activity. H2O2 was utilized to induce oxidative stress and neurotoxicity in vivo. Behavioral changes were evaluated using Open Field, Y-maze and Rotarod tests. Hyperalgesia was assessed using the tail immersion test.Results and discussionThe LC-MS/MS analysis revealed high content of kaempferol glucuronide (85%) at the extract. IC50 values of the DPPH and ABTS were 26.47 and 41.21 μg/mL, respectively. Pre-treatments with M. rotundifolia extract attenuated the behavioral changes induced by H2O2. In addition, the latency of tail withdrawal increased significantly in the treated groups suggesting central analgesic effect of M. rotundifolia extract. Moreover, the extract attenuated the deleterious effects of H2O2 and improved all liver biomarkers. The obtained results suggested that M. rotundifolia had remarkable antioxidant and neuroprotective effects and may prevent oxidative stress related disorders.

Mentha suaveolens Leaves Extract‐Mediated Synthesis of CoO@TiO2 and Fe2O3@TiO2 Core/Shell Nanoparticles with Synergistic Antimicrobial and Antioxidant Activities

“…These compounds scavenge free radicals, which are reactive molecules that can damage cells and contribute to oxidative stress. The antioxidant activity of M. suaveolens has been shown to protect against various oxidative stress‐related conditions, such as cancer, cardiovascular diseases, and neurodegenerative disorders [30] . Mentha suaveolens has also been shown to possess anti‐inflammatory properties, which are attributed to the presence of flavonoids and other polyphenolic compounds [31] .…”

“…The antioxidant activity of M. suaveolens has been shown to protect against various oxidative stress-related conditions, such as cancer, cardiovascular diseases, and neurodegenerative disorders. [30] Mentha suaveolens has also been shown to possess anti-inflammatory properties, which are attributed to the presence of flavonoids and other polyphenolic compounds. [31] These compounds inhibit the production of inflammatory mediators, such as prostaglandins and leukotrienes, and thereby reduce inflammation.…”