Mercury (Hg) exposure and its effects on Saudi breastfed infant's neurodevelopment

Al‐Saleh, Iman; Nester, Michael; Abduljabbar, Mai; Al-Rouqi, Reem; Eltabache, Chafica; Al-Rajudi, Tahreer; Elkhatib, Rola

doi:10.1016/j.ijheh.2015.10.002

Cited by 37 publications

(9 citation statements)

References 79 publications

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“…A few studies have reported substantial human exposure to inorganic Hg, which may come from the use of personal products, such as a skin-lightening cosmetics, traditional remedies and ritualistic and spiritual practices. The toxicokinetics of Hg, including its absorption, distribution, metabolism, and excretion are highly dependent on its chemical form (Al-Saleh et al, 2016). In traditional Indian Ayuvedic medicines, Tibetan medicines and Chinese medicines, Hg sulfides have been included in the preparation of herbo-metallic substances for treatment of various diseases (Liu et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Neurobehavioral protective properties of curcumin against the mercury chloride treated mice offspring

Abu-Taweel

2019

Saudi Journal of Biological Sciences

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In the present investigation, the effects of mercuric chloride (HgCl 2 ) on the neurobehavioural and neurochemical disruption in mice offspring was studied. A total of thirty pregnant mice were divided into six groups. Group II and III were received 150 and 300 ppm of curcumin respectively. Group IV was given 10 ppm of HgCl 2 . Group V and VI were given 10 ppm of HgCl 2 with 150 and 300 ppm of curcumin respectively. In this study, treatment started from day one of pregnancy and continued until post-natal day 15 (PD 15). During weaning period, three pups in each experimental group were marked and were subjected to behavioral, physical and biochemical tests. The results revealed decreased body weight, delayed hair growth and eye opening. HgCl 2 treated pups taken more time in righting, rotating reflexes to return to normal placement, cliff avoidance compared to that of control group. HgCl 2 exposed pups showed memory and learning deficits. Anxiety behavior in treating pups was increased. Biochemical investigations showed decreased level of dopamine (DA), serotonin (5-HT) and acetylcholinesterase (AChE) in forebrain of treated pups compared to the control and curcumin groups. The protective effect of curcumin doses were significant compared to HgCl 2 group. The results indicated that the administration of curcumin showed effective activity towards biochemical and behavioral disorders obtained with the HgCl 2 treated animals. Overall, the curcumin administration revealed increased cognetion and anxiety behaviors in the treated animals. Conclusively, curcumin has a good benefits for health which can use to avoid toxicants such as Hg and other heavy metals.

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Section: Discussionmentioning

confidence: 99%

Neurobehavioral protective properties of curcumin against the mercury chloride treated mice offspring

Abu-Taweel

2019

Saudi Journal of Biological Sciences

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“…Of note, occupation (e.g., mining) is another important source of exposure for humans and is associated with possible multi-organ toxicity [ 102 ]. As for the influence of Hg on neurodevelopment, a cross-sectional study, involving healthy Saudi mothers and their infants (age 3–12 months), showed an association between Hg exposure and neurodevelopmental delay, with possible negative effects persisting also in adulthood [ 103 ]. Interestingly, curcumin appeared to mitigate Hg toxicity in animal models [ 102 ].…”

Section: Role Of Curcumin In Pregnancymentioning

confidence: 99%

Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications?

et al. 2020

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Curcumin, the main polyphenol contained in turmeric root (Curcuma longa), has played a significant role in medicine for centuries. The growing interest in plant-derived substances has led to increased consumption of them also in pregnancy. The pleiotropic and multi-targeting actions of curcumin have made it very attractive as a health-promoting compound. In spite of the beneficial effects observed in various chronic diseases in humans, limited and fragmentary information is currently available about curcumin’s effects on pregnancy and pregnancy-related complications. It is known that immune-metabolic alterations occurring during pregnancy have consequences on both maternal and fetal tissues, leading to short- and long-term complications. The reported anti-inflammatory, antioxidant, antitoxicant, neuroprotective, immunomodulatory, antiapoptotic, antiangiogenic, anti-hypertensive, and antidiabetic properties of curcumin appear to be encouraging, not only for the management of pregnancy-related disorders, including gestational diabetes mellitus (GDM), preeclampsia (PE), depression, preterm birth, and fetal growth disorders but also to contrast damage induced by natural and chemical toxic agents. The current review summarizes the latest data, mostly obtained from animal models and in vitro studies, on the impact of curcumin on the molecular mechanisms involved in pregnancy pathophysiology, with the aim to shed light on the possible beneficial and/or adverse effects of curcumin on pregnancy outcomes.

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“…No statistically significant association was found between breast milk mercury and infant performance on the Denver Developmental Screening Test II (DDST-II) at 3 to 12 mo of age (Al-Saleh et al. 2016a, 2016b).…”

Section: Resultsmentioning

confidence: 99%

“…A positive association was observed between mercury levels in breast milk and scoring on the Parents’ Evaluation of Developmental Status (PEDS) at 3 to 12 mo of age (Al-Saleh et al. 2016a, 2016b). However, that finding was no longer significant once the model was adjusted for variables that were significantly associated with both outcome and exposure, including z -scores of weight-for-age and weight-for-length, infant birth order, total number of full siblings, smoking status among other family members living in the same house, infant health status, mother's highest educational level, mother's working status, vaccination timing, infant taking supplements/vitamins, infant's sleeping problems, location of primary health care centers, father's smoking status, mother's taking medication, and mother’s age.…”

Section: Resultsmentioning

confidence: 99%

Infant Dietary Exposures to Environmental Chemicals and Infant/Child Health: A Critical Assessment of the Literature

LaKind¹,

Lehmann

Davis

et al. 2018

Environ Health Perspect

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Background: The benefits of breastfeeding to the infant and mother have been well documented. It is also well known that breast milk contains environmental chemicals, and numerous epidemiological studies have explored relationships between background levels of chemicals in breast milk and health outcomes in infants and children. Objectives: In this paper, we examine epidemiological literature to address the following question: Are infant exposures to background levels of environmental chemicals in breast milk and formula associated with adverse health effects? We critically review this literature a ) to explore whether exposure–outcome associations are observed across studies, and b ) to assess the literature quality. Methods: We reviewed literature identified from electronic literature searches. We explored whether exposure–outcome associations are observed across studies by assessing the quality (using a modified version of a previously published quality assessment tool), consistency, and strengths and weaknesses in the literature. The epidemiological literature included cohorts from several countries and examined infants/children either once or multiple times over weeks to years. Health outcomes included four broad categories: growth and maturation, morbidity, biomarkers, and neurodevelopment. Results: The available literature does not provide conclusive evidence of consistent or clinically relevant health consequences to infants exposed to environmental chemicals in breast milk at background levels. Conclusions: It is clear that more research would better inform our understanding of the potential for health impacts from infant dietary exposures to environmental chemicals. A critical data gap is a lack of research on environmental chemicals in formula and infant/child health outcomes. https://doi.org/10.1289/EHP1954

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Mercury (Hg) exposure and its effects on Saudi breastfed infant's neurodevelopment

Cited by 37 publications

References 79 publications

Neurobehavioral protective properties of curcumin against the mercury chloride treated mice offspring

Neurobehavioral protective properties of curcumin against the mercury chloride treated mice offspring

Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications?

Infant Dietary Exposures to Environmental Chemicals and Infant/Child Health: A Critical Assessment of the Literature

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