Mercury Poisoning and Acrodynia

Foulds, D. Michael; Copeland, Kenneth C.; Franks, Ronald

doi:10.1001/archpedi.1987.04460020014006

Cited by 11 publications

(12 citation statements)

References 3 publications

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“…In particular, normal platelet counts excluded erythromelalgia as a primary cause of the symptoms [3]. Intoxication with heavy metals, which can produce a similar clinical picture, was ex-cluded in our patients [8]. Two reports presented a possible clue to the nature of the disease by reference to the discovery of a markedly elevated urinary catecholamine excretion [1,2].…”

Section: Discussionmentioning

confidence: 82%

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Acute secondary erythermalgia and hypertension in children

Drenth

Michiels

Özsoylu³

1995

Eur J Pediatr

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We studied the clinical symptoms in nine children (seven females and two males; mean age 11.6 years) with severe but transient acute secondary erythermalgia. The classical symptoms at presentation were episodic attacks of painful burning hands and feet which felt warm with congested appearance of the feet. Each attack lasted for a mean period of 25 days (range from 6 to 56 days). The blood pressure was elevated in seven patients. Intravenous sodium nitroprusside was effective in ameliorating the symptoms with drop in blood pressure to normal in five patients; pizotifene, labetolol, prostaglandin E1 and hypnotherapy were effective in each of four separate cases. The episodes of acute secondary erythermalgia were transient in all and did not recur after a mean follow up period of 1.6 years. These cases suggest that acute secondary erythermalgia, however transient, is not rare and can be associated with mild to moderate hypertension which may respond to sodium nitroprusside. A greater awareness of this condition is necessary to make an accurate and timely diagnosis and institute appropriate therapy in order to prevent undue complications.

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Section: Discussionmentioning

confidence: 82%

“…Platelet count was normal in all patients (range 256 • 109/1-394 • 109/1). The mean ESR was slightly elevated Serum and/or urine was tested for mercury or lead in patients 2, 6 and 9 and were found to be normal [8].…”

Section: Laboratorymentioning

confidence: 97%

Acute secondary erythermalgia and hypertension in children

Drenth

Michiels

Özsoylu³

1995

Eur J Pediatr

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“…Penicillamine is a monothiol compound, not considered as effective as DMSA [11] or DMPS, at least for some effects [27]. It should not be considered a first-line agent; partly because of its toxicity profile, its use should be reserved for patients who cannot tolerate other agents [11].…”

Section: Discussionmentioning

confidence: 99%

Full Recovery from a Potentially Lethal Dose of Mercuric Chloride

et al. 2013

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“…Exposure to mercury can permanently damage the brain and kidneys, or the developing fetus (Kutsuna, 1968;Choi et al, 1978;Kanluen & Gottlieb, 1991). The predominant skin reaction is erythematous and pruritic skin rashes (Foulds et al, 1987). Regardless of the species of mercury or the route of exposure, individuals who are hypersensitive to mercury (primarily children) develop acrodynia upon exposure (Foulds et al, 1987).…”

mentioning

confidence: 99%

“…The predominant skin reaction is erythematous and pruritic skin rashes (Foulds et al, 1987). Regardless of the species of mercury or the route of exposure, individuals who are hypersensitive to mercury (primarily children) develop acrodynia upon exposure (Foulds et al, 1987). This syndrome is characterized by severe leg cramps; irritability; and erythema and subsequent peeling of the hands, nose, and soles of the feet.…”

mentioning

confidence: 99%

In Vitro Penetration of Soil-Aged Mercury Through Pig Skin

Skowronski

Turkall²,

Abdel‐Rahman³

2000

Journal of Toxicology and Environmental Health, Part A

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The dermal bioavailability of mercury "aged" in soil for 3 mo was compared to that of pure mercury (without soil) and to mercury in brief contact with soil (16 h). Studies were conducted in vitro with [203Hg]mercuric chloride on dermatomed male pig skin by flow-through diffusion cell methodology. Less than 0.5% of the initial mercury dose penetrated through skin into receptor fluid after each treatment. The majority of pure mercury became covalently bound to skin. However, a short contact time with either an Atsion (sandy) or Keyport (clay) soil significantly decreased the total penetration of mercury (sum of receptor fluid and skin) by 40%. After aging, a 95% reduction in total penetration was observed for the compound relative to chemical without soil. Both soils bind mercury more strongly with time, as evidenced by larger quantities of radioactivity in soil and smaller amounts in skin decontaminate after aging than in soil for 16 h. Decreased mercury bioavailability with aging indicates lower health risk and reduced need for soil cleanup.

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Mercury Poisoning and Acrodynia

Cited by 11 publications

References 3 publications

Acute secondary erythermalgia and hypertension in children

Acute secondary erythermalgia and hypertension in children

Full Recovery from a Potentially Lethal Dose of Mercuric Chloride

In Vitro Penetration of Soil-Aged Mercury Through Pig Skin

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