2019
DOI: 10.1186/s11658-019-0167-8
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Mesenchymal stem cells decrease blood–brain barrier permeability in rats with severe acute pancreatitis

Abstract: Background Impairment of the blood–brain barrier (BBB) could result in secondary cerebral edema and life-threatening pancreatic encephalopathy in patients with severe acute pancreatitis (SAP). Mesenchymal stem cells (MSCs) have been widely adopted in clinical research because of their pleiotropic functions. The aim of this study was to investigate the impact of MSCs on BBB permeability in SAP and the potential mechanisms driving these effects. Methods Sprague-Dawley rat… Show more

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Cited by 14 publications
(11 citation statements)
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“…As described previously, systemic inflammation is closely associated with altered permeability of BBB, and mechanism of LPS-induced BBB disruption is well elaborated [ 13 ]. Lin et al present that SAP results in enhanced BBB permeability and secondary brain edema in a rat model [ 14 ]. Pathological H&E staining in our case shows an extensive infiltration of inflammatory cells through BBB in the hemorrhagic brain tissue, which indicates a severe neuroinflammation.…”
Section: Discussionmentioning
confidence: 99%
“…As described previously, systemic inflammation is closely associated with altered permeability of BBB, and mechanism of LPS-induced BBB disruption is well elaborated [ 13 ]. Lin et al present that SAP results in enhanced BBB permeability and secondary brain edema in a rat model [ 14 ]. Pathological H&E staining in our case shows an extensive infiltration of inflammatory cells through BBB in the hemorrhagic brain tissue, which indicates a severe neuroinflammation.…”
Section: Discussionmentioning
confidence: 99%
“…As is known, the brain vascular endothelial cells were the major component of BBB, which mainly expressed the TJ proteins. [6][7][8] Thus, we further conducted in vitro experiments with bEND.…”
Section: Oridonin Improved Bbb Integrity After Ischaemic Strokementioning
confidence: 99%
“…Additionally, MSC treatment inhibited apoptosis of brain microvascular endothelial cells through upregulation of claudin‐5 and downregulation of matrix metalloproteinase‐9. Consequently, damage to blood ‐ brain barrier and its permeability were reduced, leading to protective effects in rats with SAP 71 …”
Section: Overview Of Pancreatitismentioning
confidence: 99%