Mesenchymal tumors of the prostate

McKenney, Jesse K.

doi:10.1038/modpathol.2017.155

Cited by 54 publications

(42 citation statements)

References 60 publications

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“…Based on histopathological and IHC evaluation of the specimen obtained postsurgery, a diagnosis of SFT of the prostate was rendered. A review article authored by McKenney documents that benign sub-epithelial connective tissue or benign prostatic hyperplasia can simulate SFT, in superficial biopsies obtained by the transurethral method (6). Additionally, the differential diagnosis of prostatic SFT in resected specimen encompasses a wide range of spindle cell lesions namely stromal tumor of uncertain malignant potential (STUMP), prostatic stromal sarcoma (PSS), smooth muscle tumors such as leiomyoma and leiomyosarcoma, fibrosarcoma, inflammatory myofibroblastic tumor, gastrointestinal stromal tumor (GIST), sarcomatoid carcinoma, rhabdomyosarcoma and schwannoma.…”

Section: Discussionmentioning

confidence: 99%

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Solitary Fibrous Tumor of the Prostate: A Diagnostic Challenge: A Case Report

et al. 2020

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Solitary fibrous tumor (SFT) of prostate is an unusual type of mesenchymal neoplasm that can elicit a benign or malignant phenotype. It represents a diagnostic challenge as it can simulate poorly differentiated adenocarcinoma and various mesenchymal neoplasms of prostate. We report a case of prostate SFT in a 54-year-old patient, which was clinically misdiagnosed as nodular hyperplasia of prostate with cystitis. However, on follow-up, he was not relieved by the designated treatment. Furthermore, he complained of exacerbation of symptoms and consequently, had to undergo open prostatectomy. Based on histopathological and immunohistochemical (IHC) assessment, a diagnosis of SFT of the prostate was rendered. Additionally, we have discussed the histological mimics of SFT and the diagnostic and prognostic importance of IHC while evaluating such lesions.

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Section: Discussionmentioning

confidence: 99%

“…Rest of the spindle cell neoplasms, unlike SFT, are negative for CD34(4,6). Osamu et al reported poorly differentiated adenocarcinoma mimicking as SFT, as the initial prostatic biopsy was pan-cytokeratin positive.…”

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Solitary Fibrous Tumor of the Prostate: A Diagnostic Challenge: A Case Report

et al. 2020

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“…Less than 40 cases of PSS have been reported in the literature (1). PSS has been reported to occur between the ages of 25 and 86 years.…”

Section: Prostatic Stromal Tumorsmentioning

confidence: 99%

“…STUMP is typically indolent, and generally cured with complete resection (3,8). However, as sarcomatoid differentiation may occur rarely, close follow-up is required in cases where complete resection is not possible (1,3).…”

Section: Prostatic Stromal Tumorsmentioning

confidence: 99%

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Mesenchymal Tumors of the Prostate

Öznur¹

2018

jus

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Analysis of three primary prostatic sarcoma cases and literature review

Wei,

Wang,

Xie

et al. 2024

The Prostate

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ObjectiveThe objective of this study is to evaluate the clinical presentations, diagnostic approaches, and treatment modalities for primary prostate sarcoma postradical prostatectomy, aiming to enhance its diagnosis and management.MethodsWe retrospectively reviewed the clinical records of three male patients diagnosed with primary prostate sarcoma at Beijing Chaoyang Hospital, affiliated with Capital Medical University, from February 2014 to February 2024. All patients underwent transrectal prostate biopsies, which informed the decision to proceed with laparoscopic radical prostatectomies. After surgery, one patient received a combination of epirubicin and ifosfamide as immunotherapy, along with external beam radiotherapy. After comprehensive discussions regarding potential benefits and risks, the remaining two patients decided against undergoing radiotherapy and chemotherapy.ResultsBased on the pathological examination results, two patients were diagnosed with stromal sarcoma and one with spindle cell sarcoma, all classified as high‐grade sarcomas. Immunohistochemical analysis showed that all three cases were positive for VIMENTIN, but other results did not show significant specificity. During the follow‐up period, one patient died within 12 months, and two patients were lost to follow‐up after 6 months. However, there were no evident signs of recurrence observed during the follow‐up period.ConclusionsPrimary prostate sarcoma is extremely rare and typically has a poor prognosis once diagnosed. Early diagnosis should be based on pathological and immunohistochemical testing results, followed by prompt surgical treatment and adjuvant radiotherapy and chemotherapy. Despite these measures, recurrence is common, underscoring the need for a detailed and appropriate treatment plan and systematic therapy for affected patients.

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Mesenchymal tumors of the prostate

Cited by 54 publications

References 60 publications

Solitary Fibrous Tumor of the Prostate: A Diagnostic Challenge: A Case Report

Solitary Fibrous Tumor of the Prostate: A Diagnostic Challenge: A Case Report

Mesenchymal Tumors of the Prostate

Analysis of three primary prostatic sarcoma cases and literature review

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