Mesenchymal tumours of the bladder and prostate: an update

Tavora, Fabio; Kryvenko, Oleksandr N.; Epstein, Jonathan I.

doi:10.1097/pat.0b013e32835c768b

Cited by 33 publications

(25 citation statements)

References 126 publications

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“…In man, both benign and malignant tumors of smooth muscle origin are the most common mesenchymal tumors of the bladder [35]. Rhabdomyosarcoma of the bladder is relatively rare; however, the urinary bladder is believed to be the most common location for this type of tumor in the pediatric population since 90% of rhabdomyosarcomas in children are seen in the bladder [35].…”

Section: Resultsmentioning

confidence: 99%

“…Rhabdomyosarcoma of the bladder is relatively rare; however, the urinary bladder is believed to be the most common location for this type of tumor in the pediatric population since 90% of rhabdomyosarcomas in children are seen in the bladder [35]. Of the three types of rhabdomyosarcomas (embryonal, alveolar, and pleomorphic) by far the most common is the embryonal type [35, 38]. …”

Section: Resultsmentioning

confidence: 99%

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Bovine Papillomavirus Type 2 Infection and a Series of Mesenchymal Tumors of the Urinary Bladder in Cattle

Martano

Roperto

Stocco

et al. 2013

BioMed Research International

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This report describes the histopathology of two hundred and fifty-three mesenchymal tumors of the urinary bladder in cattle grazing on lands rich in bracken fern. Approximately 80% were hemangiomas and angiosarcomas. Hemangioma (capillary, cavernous, and large vessels) was the most frequent mesenchymal tumor and was more common than angiosarcoma. Although the appearance of endothelial cells can vary remarkably, epithelioid angiosarcomas, often containing multinucleated cells, were the most frequent malignant vascular tumors. Hemangiopericytoma and tumors of muscle and soft connective tissue origin, alone and/or in association with tumor-like lesions, were less frequently seen. Furthermore, forty-five cases of intravascular papillary endothelial hyperplasia (IPEH), a lesion not previously reported in the urinary bladder of cattle, were also described. Bovine papillomavirus type-2 DNA was amplified in tumor samples. Forty vascular tumors were investigated by dual-labeling immunofluorescence, and, for the first time, a coexpression of E5 and platelet-derived growth factor β receptor (PDGFβR) was shown to occur. The results show that the BPV-2 E5 oncoprotein binds to the activated form of the PDGFβ receptor thus playing an important role in mesenchymal as well as epithelial carcinogenesis of the urinary bladder. Furthermore, these findings demonstrate that BPV-2 infects both epithelial and mesenchymal cells.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Bovine Papillomavirus Type 2 Infection and a Series of Mesenchymal Tumors of the Urinary Bladder in Cattle

Martano

Roperto

Stocco

et al. 2013

BioMed Research International

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show abstract

“…Leiomyoma is seen rarely and less than 100 cases have been reported in the literature (9). Microscopically, they are nonatypical or less atypical tumors consisting of well-circumscribed crossing fascicular structures and having no mitotic activity.…”

Section: Leiomyomamentioning

confidence: 99%

“…It is the most common sarcoma in the prostate in adults in the 5 th to 8 th decades of life (2,9). It is seen as poor-circumscribed infiltrative nodules between 1 and 25 cm in diameter.…”

Section: Leiomyosarcomamentioning

confidence: 99%

Mesenchymal Tumors of the Prostate

Öznur¹

2018

jus

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“…The expression and characterization of recombinant viral oncoproteins are required to obtain biotechnological products as antibodies and potential vaccines [9, 15, 35–37]. Further studies show association of oncoproteins and cell compounds, as PDGF β receptor and their actions in transformation of epithelial cell to mesenchymal cell as well as epithelial carcinogenesis of the urinary bladder [17, 33, 38]. The oncoproteins also act on host cell chromatin, in epithelial and blood cells [18, 23, 27, 39].…”

mentioning

confidence: 99%