Mesoporous molecularly imprinted polymer nanoparticles as a sustained release system of azithromycin

Sheybani, Simin; Hosseinifar, Tolou; Abdouss, Majid; Mazinani, Saeedeh

doi:10.1039/c5ra11970g

Cited by 32 publications

(10 citation statements)

References 19 publications

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“…Raising the concentration of Al‐CD, it was expected to increase the number of CD groups available for interaction with 5‐FU and subsequently better drug entrapment in the nanoparticles. Nevertheless, in sample 5 high crosslinking density decreased the loading efficiency of sample because the flexibility of nanoparticles was reduced flexibility of nanoparticles by increasing the crosslinker which resulted in a lower loading capacity for this sample …”

Section: Resultsmentioning

confidence: 95%

Pressure responsive nanogel base on Alginate‐Cyclodextrin with enhanced apoptosis mechanism for colon cancer delivery

Hosseinifar

Sheybani

Abdouss

et al. 2017

J Biomedical Materials Res

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5-Fluorouracil (5-Fu) commonly use in the treatment of different kinds of cancer, but limited cellular uptake and death is still a problem. Herein, we report a simple process for the synthesis of pressure-sensitive nanogels that indicate to be appropriate in the delivery of 5-Fu. The hydrogels (Al-CD) prepare by crosslinking of alginate (Al) with modified beta Cyclodextrin (β-CD) as Crosslinker. Next, nanoparticles obtaine by an emulsification method. 5-Fu as model drug loades into the Al-CD nanogels easily by mixing it in aqueous solution with the nanoparticles. The results revealed that the Al-CD nanogels are cytocompatible. They have also a noticeable drug encapsulation (82.1 ±5.7%) while they can release (in vitro controlled) 5-Fu in conditions that imitate the intravascular pressure conditions. These nanogels can rapidly be taken up by HT-29 cells (a colon cell line). In addition, a higher 5-Fu intracellular accumulation and a significant cell death extension by apoptosis mechanism is notice when compare with free 5-Fu. Accordingly, the developed nanogels can be employe as an excellent candidate to overcome the inefficiency of 5-Fu in anticancer treatments and possibly can employe for further evaluation as a chemotherapical agent in applications beyond cancer. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 349-359, 2018.

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Section: Resultsmentioning

confidence: 95%

Pressure responsive nanogel base on Alginate‐Cyclodextrin with enhanced apoptosis mechanism for colon cancer delivery

Hosseinifar

Sheybani

Abdouss

et al. 2017

J Biomedical Materials Res

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“…To study the release behavior of DCF from nanocarriers, the experimental release data were normalized to fit to the following release kinetic models. The zero‐order, first‐order, Higuchi, and Ritger‐Peppas release kinetic models are respectively expressed as

\frac{M_{t}}{M_{\infty}} = k_{0} t,

ln ((), 1 - \frac{M_{t}}{M_{\infty}}) = - k_{1} t,

\frac{M_{t}}{M_{\infty}} = k_{H} t^{1 / 2},

and

\frac{M_{t}}{M_{\infty}} = k_{p} t^{n},

where M t stands for the amount of drug released cumulatively at time t and M ∞ is the total amount of DCF loaded. The parameters k 0 , k 1 , k H , and k p are the zero‐order, first‐order, Higuchi, and Ritger‐Peppas release rate constants, respectively, and n is the diffusional release exponent.…”

Section: Resultsmentioning

confidence: 99%

Molecularly imprinted polymer nanocarriers for recognition and sustained release of diclofenac

Zheng

Wang

Cheng

2018

Polymers for Advanced Techs

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In this study, a series of imprinted poly(methacrylic acid-co-ethylene glycol dimethacrylate) nanocarriers for diclofenac and corresponding nonimprinted polymer nanocarriers have been synthesized in 4 different types of solvents by precipitation polymerization. The products were characterized by Fourier transform infrared, scanning electron microscopy, dynamic light scattering, and Brunauer-Emmett-Teller measurement. Results showed that uniformly sized molecularly imprinted polymer (MIP) nanospheres with relatively good porosity could only be obtained in acetonitrile. The effects of solvents on the recognition and release properties of polymer particles were also carefully investigated. The binding experiments indicated that MIPs prepared in acetonitrile displayed much higher binding capacity than other MIPs with a maximum binding capacity of 65.18 mg g −1 . The Scatchard analysis showed that synthetic MIPs have special recognition sites for diclofenac, while nonimprinted polymers have not. The Sips model could provide a best fit to the equilibrium data of nanocarriers over whole concentrations. The experimental data of an adsorption kinetic study were well fitted to the pseudo-second-order kinetic model, indicating the chemisorption mechanism between diclofenac and MIPs in the process of adsorption. The drug release of diclofenac from MIPs could well be described by the Ritger-Peppas model, suggesting a non-Fickian diffusion mechanism. In addition, we successfully used MIPs to extract diclofenac at low levels from fetal bovine serum.

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“…Molecular imprinting technique and precipitation polymerization have been used to prepare AZ-imprinted poly(methacrylic acid- co -ethylene glycol dimethacrylate) NPs [ 40 ]. These NPs presented higher AZ loading capacity in comparison with non-imprinted NPs and lower cytotoxicity against L929 fibroblast cells.…”

Section: Areas Of Applicationmentioning

confidence: 99%

Antimicrobial Polymers in the Nano-World

2017

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Infections are one of the main concerns of our era due to antibiotic-resistant infections and the increasing costs in the health-care sector. Within this context, antimicrobial polymers present a great alternative to combat these problems since their mechanisms of action differ from those of antibiotics. Therefore, the microorganisms’ resistance to these polymeric materials is avoided. Antimicrobial polymers are not only applied in the health-care sector, they are also used in many other areas. This review presents different strategies that combine nanoscience and nanotechnology in the polymer world to combat contaminations from bacteria, fungi or algae. It focuses on the most relevant areas of application of these materials, viz. health, food, agriculture, and textiles.

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Mesoporous molecularly imprinted polymer nanoparticles as a sustained release system of azithromycin

Abstract: A combination of a molecular imprinting technique and precipitation polymerization was applied to develop novel azithromycin-imprinted poly(methacrylic acid-co-ethylene glycol dimethacrylate) nanoparticles for sustained release of azithromycin (AZM).

Cited by 32 publications

References 19 publications

Pressure responsive nanogel base on Alginate‐Cyclodextrin with enhanced apoptosis mechanism for colon cancer delivery

Pressure responsive nanogel base on Alginate‐Cyclodextrin with enhanced apoptosis mechanism for colon cancer delivery

Molecularly imprinted polymer nanocarriers for recognition and sustained release of diclofenac

Antimicrobial Polymers in the Nano-World

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