Mesoporous silica nanoparticle: Heralding a brighter future in cancer nanomedicine

Abbasi, Milad; Ghoran, Salar Hafez; Niakan, Mohammad; Jamali, Kazem; Moeini, Zohre; Jangjou, Ali; Izadpanah, Peyman; Amani, Ali Mohammad

doi:10.1016/j.micromeso.2021.110967

Cited by 31 publications

(15 citation statements)

References 360 publications

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“…Organic metals, polymers, and inorganic materials, especially silica, are the most frequently used materials for formulations. Thus far, many studies have reported that MSN-based nanoparticles can be used to detect cancer in diagnostic methods, such as magnetic resonance imaging, fluorescence imaging, ultrasound imaging, positron emission tomography (PET), photoacoustic imaging, or computed tomography (CT) [ 128 ] ( Figure 8 ). Ovarian cancer, as one of the deadliest diseases in women, also requires more accurate and advanced detection to help patients receive early therapy to lower mortality and increase the survival rate.…”

Section: Application Of Msns In Disease Diagnosismentioning

confidence: 99%

Mesoporous Silica Nanoparticles as a Potential Nanoplatform: Therapeutic Applications and Considerations

Djayanti

Maharjan

Cho

et al. 2023

IJMS

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With advances in nanotechnology, nanoparticles have come to be regarded as carriers of therapeutic agents and have been widely studied to overcome various diseases in the biomedical field. Among these particles, mesoporous silica nanoparticles (MSNs) have been investigated as potential nanocarriers to deliver drug molecules to various target sites in the body. This review introduces the physicochemical properties of MSNs and synthesis procedures of MSN-based nanoplatforms. Moreover, we focus on updating biomedical applications of MSNs as a carrier of therapeutic or diagnostic cargo and review clinical trials using silica-nanoparticle-based systems. Herein, on the one hand, we pay attention to the pharmaceutical advantages of MSNs, including nanometer particle size, high surface area, and porous structures, thus enabling efficient delivery of high drug-loading content. On the other hand, we look through biosafety and toxicity issues associated with MSN-based platforms. Based on many reports so far, MSNs have been widely applied to construct tissue engineering platforms as well as treat various diseases, including cancer, by surface functionalization or incorporation of stimuli-responsive components. However, even with the advantageous aspects that MSNs possess, there are still considerations, such as optimizing physicochemical properties or dosage regimens, regarding use of MSNs in clinics. Progress in synthesis procedures and scale-up production as well as a thorough investigation into the biosafety of MSNs would enable design of innovative and safe MSN-based platforms in biomedical fields.

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Section: Application Of Msns In Disease Diagnosismentioning

confidence: 99%

Mesoporous Silica Nanoparticles as a Potential Nanoplatform: Therapeutic Applications and Considerations

Djayanti

Maharjan

Cho

et al. 2023

IJMS

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“…Mesoporous silica nanoparticles (MSNs) have been widely used as suitable substances for carrying nanosilver because of their simplicity of surface modification, excellent biocompatibility, large surface area, and uniform porous framework 21 . MSNs can have a controlled release of Ag ions and safeguard nanosilver from agglomeration, leading to prolonged efficiency while significantly lowering undesirable toxic effects.…”

Section: Introductionmentioning

confidence: 99%

An intriguing approach toward antibacterial activity of green synthesized Rutin-templated mesoporous silica nanoparticles decorated with nanosilver

Abbasi

Gholizadeh

Kasaee

et al. 2023

Sci Rep

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In recent years, mesoporous silica nanoparticles (MSNs) have been applied in various biomedicine fields like bioimaging, drug delivery, and antibacterial alternatives. MSNs could be manufactured through green synthetic methods as environmentally friendly and sustainable synthesis approaches, to improve physiochemical characteristics for biomedical applications. In the present research, we used Rutin (Ru) extract, a biocompatible flavonoid, as the reducing agent and nonsurfactant template for the green synthesis of Ag-decorated MSNs. Transmission electron microscopy (TEM), zeta-potential, x-ray powder diffraction (XRD), fourier transform infrared (FTIR) spectroscopy analysis, scanning electron microscopy (SEM), brunauer–emmett–teller (BET) analysis, and energy-dispersive system (EDS) spectroscopy were used to evaluate the Ag-decorated MSNs physical characteristics. The antimicrobial properties were evaluated against Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), and also different types of candida. The cytotoxicity test was performed by using the MTT assay. Based on the findings, the significant antimicrobial efficacy of Ru-Ag-decorated MSNs against both gram positive and gram negative bacteria and different types of fungi was detected as well as acceptable safety and low cytotoxicity even at lower concentrations. Our results have given a straightforward and cost-effective method for fabricating biodegradable Ag-decorated MSNs. The applications of these MSNs in the domains of biomedicine appear to be promising.

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“…1 ). In most of the instances, the published reviews from us and others are focused on either of the aspects of advancements, for instance, polymer coating/surface modification [ 50 ], or capping [ 33 , 51 ], or framework modification [ 52 ], or discussions restricted to stimuli-responsive delivery [ 53 ], and one of the specific biomedical applications of cancer therapy [ 26 , 31 , 54 ], tissue engineering [ 29 ], as well as bioimaging [ 55 ]. To be precise, in our previous review on advanced MSNs, we were intended to explore the advanced prototypes of MSNs, in which the discussions were predominantly focused only on the physicochemical features and morphological attributes after modifying the MSNs with different ways of surface modification, pore alteration, and molecular impregnation in MSN frameworks [ 43 ].…”

Section: Introductionmentioning

confidence: 99%

Nanoarchitectured prototypes of mesoporous silica nanoparticles for innovative biomedical applications

et al. 2022

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Despite exceptional morphological and physicochemical attributes, mesoporous silica nanoparticles (MSNs) are often employed as carriers or vectors. Moreover, these conventional MSNs often suffer from various limitations in biomedicine, such as reduced drug encapsulation efficacy, deprived compatibility, and poor degradability, resulting in poor therapeutic outcomes. To address these limitations, several modifications have been corroborated to fabricating hierarchically-engineered MSNs in terms of tuning the pore sizes, modifying the surfaces, and engineering of siliceous networks. Interestingly, the further advancements of engineered MSNs lead to the generation of highly complex and nature-mimicking structures, such as Janus-type, multi-podal, and flower-like architectures, as well as streamlined tadpole-like nanomotors. In this review, we present explicit discussions relevant to these advanced hierarchical architectures in different fields of biomedicine, including drug delivery, bioimaging, tissue engineering, and miscellaneous applications, such as photoluminescence, artificial enzymes, peptide enrichment, DNA detection, and biosensing, among others. Initially, we give a brief overview of diverse, innovative stimuli-responsive (pH, light, ultrasound, and thermos)- and targeted drug delivery strategies, along with discussions on recent advancements in cancer immune therapy and applicability of advanced MSNs in other ailments related to cardiac, vascular, and nervous systems, as well as diabetes. Then, we provide initiatives taken so far in clinical translation of various silica-based materials and their scope towards clinical translation. Finally, we summarize the review with interesting perspectives on lessons learned in exploring the biomedical applications of advanced MSNs and further requirements to be explored. Graphical Abstract

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Mesoporous silica nanoparticle: Heralding a brighter future in cancer nanomedicine

Cited by 31 publications

References 360 publications

Mesoporous Silica Nanoparticles as a Potential Nanoplatform: Therapeutic Applications and Considerations

Mesoporous Silica Nanoparticles as a Potential Nanoplatform: Therapeutic Applications and Considerations

An intriguing approach toward antibacterial activity of green synthesized Rutin-templated mesoporous silica nanoparticles decorated with nanosilver

Nanoarchitectured prototypes of mesoporous silica nanoparticles for innovative biomedical applications

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