Meta-analysis: Comparison of F-18 Fluorodeoxyglucose-Positron Emission Tomography and Bone Scintigraphy in the Detection of Bone Metastases in Patients With Breast Cancer

Abstract

It remains inconclusive whether FDG-PET or bone scintigraphy is superior in detecting osseous metastasis from breast cancer. However, FDG-PET does have a higher specificity and may better serve as a confirmatory test than bone scintigraphy and used to monitor response to therapy.

Diagnostic Value of18F-FDG PET/CT in Comparison to Bone Scintigraphy, CT and18F-FDG PET for the Detection of Bone Metastasis

“…CT components of PET/CT can give precise locations of the metastasis sites and further describe the morphological changes with osteoblastic or lyitc. CT is also a vital choice for initial evaluation the risk of bone fractures (Shie et al, 2008).…”

“…The images of BS were interpreted by two experienced nuclear medicine physicians, PET and PET/CT images by 2 experienced nuclear medicine physicians, and CT images by one double board-certified nuclear medicine physician and radiologist and one board-certified radiologist.Each image was performed to 10 separate areas (Skull, Cervical spine, Thoracic spine, Lumbar spine, Sacrum with coccyx, Pelvis, Long bone (Upper and lower extremities), Sternum, Ribs, Scapula and clavicle) and each site of abnormally increased uptake of 99mTc-MDP or 18 F-FDG was recorded and categorized as normal, malignant or equivocal. Suspected focal bone marrow infiltrations by 18 F-FDG PET were compared with morphological changes in the corresponding CT scan (Shinji et al, 2007;Shie et al, 2008). Lesions were diagnosed as metastases if they were associated with characteristic morphological changes on CT.…”

“…But there were conflicting evidences that 18 F-FDG PET was less sensitive than BS in breast and colon cancer. It seemed that the diagnosis value of PET was tumor specific (Shie et al, 2008;Choi et al, 2012;Montini et al, 2012). The morphological types of the metastasis lesions appeared to be relevant with FDG uptake, too.…”

Comparison of bone scintigraphy and magnetic resonance imaging in suspected cases of with lumbosacral metastasis in patient with prostate cancer

“…Bu nedenle sadece tümör aktivitesinin olduğu alanlarda değil; dejenerasyon, inflamasyon gibi benign lezyonlarda da tutulum artışı göstermektedir. 9,10 Sintigrafinin kemik metastazı duyarlılığı literatürde % 62-89 olarak bildirilmektedir. 5,11 MRG'nin kemik metastazlarının saptanmasında yüksek duyarlılığa sahip olduğu literatürde gösterilmiştir.…”

Nuclear Imaging and Early Breast Cancer Detection

“…Osteolytic lesions are more common than sclerotic type (80 vs. 15−20%). FDG may miss sclerotic lesions, but a better specificity for PET/CT than for bone scintigraphy in their detection has been recently reported [36,37].…”