Meta‐Analysis of Association Between Interleukin‐1β C‐511T Polymorphism and Chronic Periodontitis Susceptibility

Zeng, Xian‐Tao; Liu, Dongyan; Kwong, Joey S.W.; Li, Weidong; Xia, Lingyun; Mao, Min

doi:10.1902/jop.2015.140698

Cited by 46 publications

(49 citation statements)

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“…Furthermore, in another meta-analysis conducted by Zeng et al (2015), two of the studies (Loo et al, 2012;Hao et al, 2013) potentially involved the same subjects of the Chinese population. The present meta-analysis was strengthened by the exclusion of duplicated studies, and significant results were revealed in the subgroup and overall analyses.…”

Section: Discussionmentioning

confidence: 99%

Association between the interleukin-1β C-511T polymorphism and periodontitis: a meta-analysis in the Chinese population

Wang¹,

He²,

Xu³

et al. 2017

Genet. Mol. Res.

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ABSTRACT. The association between the interleukin-1 beta (IL-1β) C-511T (or rs16944) polymorphism and periodontitis remains inconclusive, even though there have been previous studies on this association. To assess the effects of IL-1β C-511T variants on the risk of development of periodontitis, a meta-analysis was performed in a single ethnic population. Studies, published up to December 2015, were selected for the meta-analysis from PubMed and Chinese databases. The associations were assessed with pooled OR and 95%CI. This meta-analysis identified 8 studies, including 1276 periodontitis cases and 1558 controls. Overall, a significant association between the IL-1β C-511T polymorphism and periodontitis was found 1.68). In the subgroup analyses based on geographical area(s), source of controls, and type of periodontitis, significant results were obtained for the association between IL-1β C-511T variants and periodontitis. Our meta-analysis indicated that the IL-1β C-511T polymorphism may be a genetic susceptibility factor for periodontitis in the Chinese population. This marker could be used to identify Chinese individuals at a high risk for periodontitis.

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Section: Discussionmentioning

confidence: 99%

Association between the interleukin-1β C-511T polymorphism and periodontitis: a meta-analysis in the Chinese population

Wang¹,

He²,

Xu³

et al. 2017

Genet. Mol. Res.

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“…All analyses were conducted using the Comprehensive Meta-Analysis v2.2 software (Zeng et al, 2015b). The ORs and its 95%CIs were used to evaluate the pooled and single effect size to determine whether there was a significant association between cases and controls.…”

Section: Discussionmentioning

confidence: 99%

“…Sensitivity analysis was performed to investigate the influence of a single study on overall analysis, and to test the robustness of overall results. Potential publication bias was assessed by visual inspection of funnel plots and the Egger test (Mao et al, 2013;Zeng et al, 2015b). Five genetic models were used for overall and subgroup analyses (Suo et al, 2015;Zeng et al, 2015b): A vs G, AA vs GG, AG vs GG, (AG+AA) vs GG, and AA vs (AG+GG).…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have previously investigated the association between TNF-α G-308A polymorphism and MI risk, but have yielded inconsistent results. Meta-analysis is a useful method to combine various single studies to obtain a larger sample size (Bax et al, 2007;Zeng et al, 2015a), and has been widely used in genetic association studies (Leng et al, 2013;Mao et al, 2013;Yan et al, 2014;Suo et al, 2015;Zeng et al, 2015b). In the present study, we performed a metaanalysis to evaluate the association between TNF-α G-308A polymorphism and MI risk.…”

Section: Discussionmentioning

confidence: 99%

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Association between TNF-α rs1800629 polymorphism and the risk of myocardial infarction: A meta-analysis

et al. 2016

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ABSTRACT. The tumor necrosis factor-alpha (TNF-α) G-308A polymorphism has been suggested to be a susceptibility factor for myocardial infarction (MI). However, differing results from various studies have led to controversial conclusions. Hence, we performed a meta-analysis to evaluate the association between TNF-α G-308A polymorphism and MI. Reported studies published before March 30, 2015 were included and analyzed from the PubMed and Embase databases. Study selection and data extraction were carried out independently by two authors. The odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the association between the selected variables using the Comprehensive Meta-Analysis v2.2 software. In total, 12 publications with 13 case-control studies consisting of 6037 cases and 7262 controls However, when subgroup analysis was performed according to the stages of MI, results indicated that there was a significant association between TNF-α G-308A polymorphism and the risk of acute MI. Other subgroup analyses revealed no significant associations. Current evidence suggests that TNF-α G-308A polymorphism may be associated with increased risk for acute MI.

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“…Similarly, different studies have failed to establish an association of the IL1B -511C>T polymorphism with the development of AgP and/or CP. [32729] However, in a meta-analysis, a weak association between this polymorphism and CP was observed, with the T allele representing a risk for the disease, especially among Asians. [30]…”

Section: Discussionmentioning

confidence: 99%

Interaction of IL1B and IL1RN polymorphisms, smoking habit, gender, and ethnicity with aggressive and chronic periodontitis susceptibility

et al. 2016

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Background:Although the interleukin-1 (IL-1) plays a critical role in the pathogenesis of periodontitis, associations between IL1 gene cluster polymorphisms and the disease remains unclear.Aims:To investigate the importance of IL1B-511C>T (rs16944), IL1B +3954C>T (rs1143634), and IL1RN intron 2 variable number tandem repeat (VNTR) (rs2234663) polymorphisms, individually or in combination, as the risk factors of periodontitis in a Southeastern Brazilian population with a high degree of miscegenation.Subjects and Methods:A total of 145 individuals, with aggressive (aggressive periodontitis [AgP], n = 43) and chronic (chronic periodontitis [CP], n = 52) periodontitis, and controls (n = 50) were genotyped by polymerase chain reaction (PCR) (IL1RN intron 2 VNTR) or PCR-restriction fragment length polymorphism (PCR-RFLP) (IL1B-511 C>T and IL1B + 3954C>T) techniques.Statistical Analysis:The independent t-test, Chi-square, and Fisher's exact tests were used. The SNPStats program was used for haplotype estimation and multiplicative interaction analyses.Results:The IL1B +3954T allele represented risk for CP (odds ratio [OR] = 2.84), particularly in smokers (OR = 4.43) and females (OR = 6.00). The minor alleles IL1RN*2 and *3 increased the risk of AgP (OR = 2.18), especially the IL1RN*2*2 genotype among white Brazilians (OR = 7.80). Individuals with the combinations of the IL1B + 3954T and IL1RN*2 or *3-containing genotypes were at increased risk of developing CP (OR = 4.50). Considering the three polymorphisms (rs16944, rs1143634, and rs2234663), the haplotypes TC2 and CT1 represented risk for AgP (OR = 3.41) and CP (OR = 6.39), respectively.Conclusions:Our data suggest that the IL1B +3954C>T and IL1RN intron 2 VNTR polymorphisms are potential candidates for genetic biomarkers of periodontitis, particularly in specific groups of individuals.

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Meta‐Analysis of Association Between Interleukin‐1β C‐511T Polymorphism and Chronic Periodontitis Susceptibility

Abstract: Based on currently available evidence, IL-1β C-511T polymorphism is not associated with the risk of developing CP. Additional research is warranted to further explore and confirm the association of genetic polymorphism and CP.

Cited by 46 publications

References 50 publications

Association between the interleukin-1β C-511T polymorphism and periodontitis: a meta-analysis in the Chinese population

Association between the interleukin-1β C-511T polymorphism and periodontitis: a meta-analysis in the Chinese population

Association between TNF-α rs1800629 polymorphism and the risk of myocardial infarction: A meta-analysis

Interaction of IL1B and IL1RN polymorphisms, smoking habit, gender, and ethnicity with aggressive and chronic periodontitis susceptibility

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