Metabolic changes in ischemic myocardium by nitroprusside

Vasodilator treatment for acute and chronic heart failure.

“…Some authors have reported improvement in regional myocardial metabolism and mechanical function during nitroprusside infusion (Cohn et al, 1974a;Mueller et al, 1974;Da Luz et al, 1975;Ramanathan et al, 1975) and others deterioration or no change (Kerber and Abboud, 1975;Kerber et al, 1976;Chiariello et al, 1976). Similarly, there have been contradictory and conflicting reports on the effects of nitroglycerin on the extent of myocardial ischaemic injury, as judged by changes in the magnitude of ST segment elevation after acute myocardial infarction.…”