Metabolic Consequences of Different Perioperative Fluid Therapies in the Neonatal Period

Sandström, Kerstin; Nilsson, Kjell; Andréasson, Svenerik; Niklasson, Anna; Larsson, L. E.

doi:10.1097/00132586-199310000-00047

Cited by 4 publications

(8 citation statements)

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“…, and Sandstrom et al . who found an average rise in blood glucose during surgery in children irrespective of the type of fluid used. The rise in blood glucose is explained by the metabolic and endocrine response to surgical stress resulting in an increase in counter‐regulatory hormones, mainly epinephrine and glucagon.…”

Section: Discussionmentioning

confidence: 97%

“…On the contrary, Sandstrom et al . reported no change in pH during the use of dextrose‐free fluid during surgery in neonates. The change in pH may not have been evident due to the smaller sample size of their study.…”

Section: Discussionmentioning

confidence: 99%

“…Routine use of intraoperative dextrose‐containing fluids in children has declined over the years owing to evidence that normal to high blood glucose levels are maintained during surgery even with the infusion of glucose‐free fluids . In newborns, dextrose‐containing fluid is prescribed during surgery as it is believed that they need 4–8 ml·kg −1 ·min −1 of glucose for sustaining brain development and their limited glycogen reserve makes them susceptible to hypoglycemia without glucose supply .…”

Section: Introductionmentioning

confidence: 99%

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Dextrose‐containing intraoperative fluid in neonates: a randomized controlled trial

Datta

Pawar

Baidya

et al. 2016

Pediatric Anesthesia

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All three solutions, when infused at 10 ml·kg(-1) ·h(-1) , are equally effective in maintaining glucose homeostasis, but 1% dextrose-containing fluid promotes catabolism, insulin resistance, rebound hyperglycemia, and acidosis. Therefore, 2-4% dextrose-containing fluids is more suitable compared to 1% dextrose-containing fluids for use during major neonatal surgeries requiring average fluid infusion rate of 10 ml·kg(-1) ·h(-1) .

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dextrose‐containing intraoperative fluid in neonates: a randomized controlled trial

Datta

Pawar

Baidya

et al. 2016

Pediatric Anesthesia

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“…A number of publications have shown that it is possible to use nonglucose containing maintenance infusion solutions even in neonates (7,8). However, certain risk categories do exist and a reasonable clinical compromise might be to use a 1% glucose solution as described by Dubois et al .…”

Section: Discussionmentioning

confidence: 99%

Use of albumin, blood transfusion and intraoperative glucose by APA and ADARPEF members: a postal survey

Söderlind

Salvignol

Izard

et al. 2001

Pediatric Anesthesia

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The response rate of the survey was 38% and 25% for APA and ADARPEF members, respectively. Forty-one percent of APA members reported a reduced use of albumin containing solutions following the publication of the Cochrane report compared to eight percent in the ADARPEF group (P < 0.0001). Albumin continues to be the most frequently used plasma expander in premature babies and neonates, whereas many colleagues use alternative colloids in infants and older children. A clear difference was observed in the 1-12-year-old age group between APA members favouring the use of gelatines and ADARPEF members who instead frequently use hetastarch solutions. ADARPEF members appeared to have a slightly more restrictive attitude towards blood transfusion and also reported more widespread use of erythropoetin (56% versus 9%, P < 0.0001) and predilution techniques (40% versus 23%, P < 0.04) compared with APA members. Regarding intraoperative maintenance solutions, a large proportion of both APA and ADARPEF members still use high concentrations of glucose intraoperatively, even in older children.

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“…Sandstrom et al studied whether intraoperative supply of glucose influences the dominating metabolic pathway as reflected by the RQ during pediatric anaesthesia [11]. If no glucose is administrated, increased fat metabolism, such as free fatty acids and ketones, have been observed in young children [12,13] We reported that small-dose of glucose administration, around one-third of basal metabolism, could reduce ketogenesis [14].…”

Section: Introductionmentioning

confidence: 99%

Effect of Glucose Administration on the Metabolism during Surgery

Kitamura¹,

Hirokawa

Sako³

et al. 2016

J Diabetes Metab

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Metabolic Consequences of Different Perioperative Fluid Therapies in the Neonatal Period

Cited by 4 publications

References 0 publications

Dextrose‐containing intraoperative fluid in neonates: a randomized controlled trial

Dextrose‐containing intraoperative fluid in neonates: a randomized controlled trial

Use of albumin, blood transfusion and intraoperative glucose by APA and ADARPEF members: a postal survey

Effect of Glucose Administration on the Metabolism during Surgery

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