Metabolic Factors Associated with Risk of Renal Cell Carcinoma

Abstract

Previous studies have shown that obesity and hypertension are associated with increased risk of renal cell carcinoma (RCC), but less is known about the association to other metabolic factors. In the Metabolic Syndrome and Cancer project (Me-Can) data on body mass index (BMI, kg/m2), blood pressure, and circulating levels of glucose, cholesterol, and triglycerides were collected from 560,388 men and women in cohorts from Norway, Austria, and Sweden. By use of Cox proportional hazard models, hazard ratios (HR) were calculated for separate and composite metabolic exposures. During a median follow-up of 10 years, 592 men and 263 women were diagnosed with RCC. Among men, we found an increased risk of RCC for BMI, highest vs. lowest quintile, (HR = 1.51, 95% CI 1.13–2.03), systolic blood pressure, (HR = 3.40, 95% CI 1.91–6.06), diastolic blood pressure, (HR = 3.33, 95% CI 1.85–5.99), glucose, (HR = 3.75, 95% CI 1.46–9.68), triglycerides, (HR = 1.79, 95% CI 1.00–3.21) and a composite score of these metabolic factors, (HR = 2.68, 95% CI 1.75–4.11). Among women we found an increased risk of RCC for BMI, highest vs. lowest quintile, (HR = 2.21, 95% CI 1.32–3.70) and the composite score, (HR = 2.29, 95% CI 1.12–4.68). High levels of the composite score were also associated with risk of death from RCC among both men and women. No multiplicative statistical or biological interactions between metabolic factors on risk of RCC were found. High levels of BMI, blood pressure, glucose and triglycerides among men and high BMI among women were associated with increased risk of RCC.

Metabolic Syndrome Prevalence in Renal Cell Cancer Patients

“…Those metabolic factors were high levels of BMI, BP, glucose, TG among men and BMI among women. However, the authors observed no interaction between the risk factors and RCC (Haggstrom et al, 2013). In the present study, we investigated the relationship between the risk of RCC and MetS which is referred to a constellation of interrelated metabolic risk factors.…”

Prevalence of dyslipidaemia in patients with renal cell carcinoma: a case‐control study in China

“… study. In another European cohort study, the link between triglyceride and RCC hazard was only seen in men but not in women . To our knowledge, little research has been reported on the role of LDL in carcinogenesis, especially for RCC.…”

RECURRENT PERI-OP HAEMATURIA IN REPEAT LOWER SEGMENT CAESAREAN SECTION: an unusual Presentation of Renal Cell Carcinoma in Pregnancy (A Case report with Literature Review)

“…5 Smoking, obesity and hypertension are high risk factors for this condition. 6 NSAID is another high risk factor. 7 Immediate relatives of people with RCC have 2-4 old increased risk of developing the disease.…”