2016
DOI: 10.1148/radiol.2016151654
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Metabolic Patterns in Chronic Multiple Sclerosis Lesions and Normal-appearing White Matter: Intraindividual Comparison by Using 2D MR Spectroscopic Imaging

Abstract: equally to this work.q RSNA, 2016 Purpose:To perform a direct metabolic comparison of chronic lesions and diffusely injured normal-appearing white matter (NAWM) in multiple sclerosis (MS). Materials and Methods:In this institutional review board-approved study, with the written informed consent of all patients, two-dimensional magnetic resonance spectroscopic imaging data in 46 patients with relapsing-remitting MS (median disease duration, 0.8 year) were analyzed by using the spectral quantification tool LC… Show more

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Cited by 18 publications
(24 citation statements)
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“…Even though free lipid signal has previously been reported in localized active MS lesions [34], in the MS lesions of patients with prior PML a widespread affection of brain white matter by inflammatory processes, extending beyond the visual location of PML lesions, has to be taken into consideration as an alternative source of lipid elevation. The major metabolite ratios (NAA/Cr, NAA/Cho, Cho/Cr) in MS lesions did not significantly differ from NAWM, which was in accordance with a recent larger MRS study in which a high similarity in the individual spectra of chronic MS lesions and contralateral NAWM was described [35]. These results, however, should be interpreted with caution, due to the low number of MS lesions studied.…”
Section: Discussionsupporting
confidence: 89%
“…Even though free lipid signal has previously been reported in localized active MS lesions [34], in the MS lesions of patients with prior PML a widespread affection of brain white matter by inflammatory processes, extending beyond the visual location of PML lesions, has to be taken into consideration as an alternative source of lipid elevation. The major metabolite ratios (NAA/Cr, NAA/Cho, Cho/Cr) in MS lesions did not significantly differ from NAWM, which was in accordance with a recent larger MRS study in which a high similarity in the individual spectra of chronic MS lesions and contralateral NAWM was described [35]. These results, however, should be interpreted with caution, due to the low number of MS lesions studied.…”
Section: Discussionsupporting
confidence: 89%
“…The MM at 0.9 ppm and 1.3 ppm were elevated in acute lesions compared to those in chronic lesions or in controls . A more recent study reports significantly decreased signals of MM (including lipids) at 0.9, 1.2 to 1.4, and 2.0 ppm in chronic lesions and normal‐appearing WM compared to cortical gray matter. The above‐mentioned MM differences often are connected to a particular MM peak and do not manifest over the whole spectral range.…”
Section: Discussionmentioning
confidence: 84%
“…A quantification of patient data with only a single measured MM background in the basis set leads not only to incorrect estimation of MMs but also to biased metabolic quantification. In addition, a rather diffuse MM change, such as that observed in , favors utilization of MRSI over single‐voxel spectroscopy.…”
Section: Discussionmentioning
confidence: 99%
“…Since its introduction, MRSI has evolved into a unique tool that can add valuable information about pathology in many brain disorders . In some cases MRSI can even unravel biochemical changes, where conventional MRI appears insufficient …”
Section: Introductionmentioning
confidence: 99%
“…[1][2][3][4][5] In some cases MRSI can even unravel biochemical changes, where conventional MRI appears insufficient. 6 The quality of MRSI data depends strongly on the homogeneity of the main magnetic (B 0 ) field, particularly that within each voxel. 7 B 0 inhomogeneity (ΔB 0 ) increases spectral linewidths, decreases SNR, and leads to poor performance of frequency-selective (suppression) pulses.…”
Section: Introductionmentioning
confidence: 99%