Metabolic profile of the bioactive compounds of burdock (Arctium lappa) seeds, roots and leaves

Ferracane, Rosalia; Graziani, Giulia; Gallo, Monica; Fogliano, Vincenzo; Ritieni, Alberto

doi:10.1016/j.jpba.2009.03.018

Cited by 178 publications

(135 citation statements)

References 24 publications

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“…The amount of different components of REB and LEB were analyzed using HPLC. Profile of the compounds of REB and LEB were similar with previous studies (data not shown) [13,14].…”

Section: Extract Preparationsupporting

confidence: 89%

“…Further studies showed that various components, such as Caffeic acid, diarctigenin, arctigenin, Lappaol F, and trachelogeninin root and leaves of burdock are responsible for suppression NO synthesis [11,25,26]. HPLC analysis and single quadrupole mass spectrometry of root and leaves of burdock showed that amounts of some of these components in root extract is more than leaves extract [1,4,13,14]. In general, therefore, it seems that root of burdock can be more effective than leaves of burdock for treatment inflammatory diseases related to excessive production of NO.…”

Section: Discussionmentioning

confidence: 99%

“…isolated and purified from different tissues of the burdock plant [9][10][11][12]. Ferracane et al showed that amount of these compounds varies greatly between different tissues of burdock plant [13]. Accordingly, do root and leaves of burdock have similar or different immunomodulatory properties?…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the Immunomodulatory Properties of Root and Leaves of Arctium Lappa (Burdock) in Vitro

Ahmadabad

Behnamfar

Firizi

et al. 2017

Zahedan J Res Med Sci

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Background: The roots and leaves of Arctium lappa (burdock) have been used for different therapeutic purposes, especially for diseases linked to chronic inflammation. Objectives: The present study was designed to evaluate and compare the immunomodulatory activities of root extract of burdock and leaves extract of burdock in vitro. Methods: In this experimental study, PHA-or LPS-stimulated splenocytes were treated with different concentrations of root or leaves extract of burdock and proliferation of splenocytes measured by MTT assay. The levels of IFN-γ and IL4 in the supernatants of PHAstimulated splenocytes determined using ELISA. We also studied the effects of root and leaves extract of burdock on Nitric Oxide production by LPS-stimulated macrophages using the Griess reagent. The data were analyzed by one-way ANOVA followed by Tukey's post-test using GraphPad Prism software, version 5.0. Results: Our findings showed that both root and leaves extract of burdock have suppressive effects on LPS-stimulated splenocytes proliferation, IL-4 secretion from PHA-stimulated splenocytes, and NO production from LPS-stimulated macrophage and stimulatory effects on PHA-stimulated splenocytes proliferation, and IFN-γ secretion from PHA-stimulated splenocytes. Although both root and leaves extract of burdock had similar immunomodulatory effects in vitro, stronger immunomodulatory effects seen in root extract of burdock. Conclusions: According to our results, we suggest that root of burdock is better option than leaves of burdock in modulation immune responses and inflammations.

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“…The amount of different components of REB and LEB were analyzed using HPLC. Profile of the compounds of REB and LEB were similar with previous studies (data not shown) [13,14].…”

Section: Extract Preparationsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of the Immunomodulatory Properties of Root and Leaves of Arctium Lappa (Burdock) in Vitro

Ahmadabad

Behnamfar

Firizi

et al. 2017

Zahedan J Res Med Sci

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“…Arctium lappa L. is an important natural source for several classes of bioactive compounds such as flavonoids and lignans (Ferracane et al, 2010). A. lappa has demonstrated potent antioxidant effects in vitro and in vivo (Duh, 1998;Liu et al, 2014) and protective effects in an acute experimental colitis model (De Almeida et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Polyphenolic Profile, Anti-Inflammatory and Antinociceptive Activity of an Extract from Arctium lappa L. Roots

Conea

Mogoşan

Voștinaru

et al. 2017

Not Bot Horti Agrobo

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The aim of the study was to assess the polyphenolic profile, anti-inflammatory and antinociceptive activity of Arctium lappa, a medicinal plant traditionally used in the treatment of gout, hepatitis and other inflammatory disorders. Polyphenolic profile of a hydro-glycero-ethanolic extract from Arctium lappa roots (ALE) was evaluated by HPLC-MS method. Antiinflammatory effect of the Arctium lappa extract (ALE) was determined by carrageenan-induced rat paw oedema test, while antinociceptive effect was determined by acetic acid induced writhing test in mice and Randall Selitto test in rats. HPLC-MS analysis of the extract showed the presence of chlorogenic acid (158.9 μg/mL) and quercitrin (14.4 μg/mL). The administration of ALE reduced the oedema formation in the carrageenan-induced rat paw oedema test, especially at dose of 500 mg/kg, the results being statistically significant and dose-dependent. Also, ALE showed statistically significant and dosedependent antinociceptive effects in the acetic acid induced writhing test in mice and Randall Selitto test in rats. The results of the pharmacological experiments suggest that the anti-inflammatory and antinociceptive effects of the Arctium lappa extract (ALE) may be related to the ability of polyphenols such as chlorogenic acid to inhibit the synthesis and release of some proinflammatory mediators. Our experimental data justify the traditional use of this plant in the management of some inflammatory diseases.

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“…The plant also contains flavonoids, and many researchers have demonstrated their role in treatment of diabetes (7). It is also beneficial for atherosclerosis due to its antioxidant properties and inhibitory effects on platelet adhesion (8). Burdock anti-inflammatory activity against diabetes and cerebral ischemia is attributed to its arctigenin ingredients (9,10).…”

Section: Introductionmentioning

confidence: 99%

Histopathological Evaluation of Burdock (Arctium lappa) Root Hydroalcoholic Extract on Wound Healing

Ghorat

Azizkhani

Naji

et al. 2017

Iran Red Crescent Med J

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Background: Wound healing is a process that occurs following skin lesions. Shortening healing time is of critical importance as it reduces the risk of infection, complications, and costs. Objectives: In this experimental study, 36 male Wistar rats each weighting approximately 200 -220 g were studied in six groups, each with 6 animals for 21 days. Hydroalcoholic extract of Burdock root was prepared through the maceration method. The animals

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Metabolic profile of the bioactive compounds of burdock (Arctium lappa) seeds, roots and leaves

Cited by 178 publications

References 24 publications

Comparison of the Immunomodulatory Properties of Root and Leaves of Arctium Lappa (Burdock) in Vitro

Comparison of the Immunomodulatory Properties of Root and Leaves of Arctium Lappa (Burdock) in Vitro

Polyphenolic Profile, Anti-Inflammatory and Antinociceptive Activity of an Extract from Arctium lappa L. Roots

Histopathological Evaluation of Burdock (Arctium lappa) Root Hydroalcoholic Extract on Wound Healing

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