Metabolic responses to euglycaemic hyperinsulinaemia in lactating and non-lactating sheep in vivo

Faulkner, Anne; Pollock, Helen T.

doi:10.1677/joe.0.1240059

Cited by 36 publications

(31 citation statements)

References 31 publications

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“…Endogenous glucose production was suppressed by 30 to 60% and glucose utilization was stimulated by 0 to 30% when plasma insulin concentration was increased to twofold that of basal states by insulin infusion with a maintained plasma glucose concentration [29][30][31]. This suggests that the increase in plasma insulin concentration during the postfeeding period in the present study should produce a decrease in glucose entry and no change or a slight increase in glucose utilization.…”

Section: Discussionmentioning

confidence: 49%

Combined effect of salinomycin and feeding on whole body glucose kinetics in sheep fed a high-concentrate diet

et al. 2006

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-The aim of this study was to investigate the effects of salinomycin (SL) and feeding on whole body glucose kinetics in sheep fed a high-concentrate diet (25% orchardgrass hay and 75% commercial concentrate). Four adult sheep were fed the diet with or without 20 mg·kg −1 diet of SL once daily for each 3 wk. The rates of glucose entry and utilization were determined before and during 3 h after feeding using a [ 13 C 6 ]glucose dilution approach. Ruminal characteristics and concentrations of blood volatile fatty acids (VFA) and plasma glucose and insulin were also measured. Metabolizable energy intake was unaffected (P = 0.22) with SL. Salinomycin decreased (P = 0.06) the ratio of acetate to propionate in rumen fluid. Salinomycin increased (P = 0.01) both rates of entry and utilization of glucose, but did not affect (P > 0.10) concentrations of blood VFA or plasma glucose or insulin. Feeding caused gradual increases in concentrations of blood acetate (P < 0.01) and propionate (P = 0.01), a transient increase in plasma insulin concentration (P = 0.05), a transient decrease in plasma glucose concentration (P < 0.01), and persistent increases in both rates of glucose entry (P < 0.01) and utilization (P < 0.01). No SL × feeding interaction was observed (P > 0.10) on any measurements. We conclude that SL and feeding would have an additive effect on both rates of glucose entry and utilization without modifications with SL to feeding responses of peripheral concentrations of blood VFA, plasma glucose and insulin.feeding / glucose metabolism / insulin / ionophore / propionate / sheep

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Section: Discussionmentioning

confidence: 49%

Combined effect of salinomycin and feeding on whole body glucose kinetics in sheep fed a high-concentrate diet

et al. 2006

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“…This [13]. Insulin infusion reduces whole body protein degradation and concentrations of plasma free amino acids [7,25]. There [17].…”

Section: Discussionmentioning

confidence: 99%

The effect of supplemental propionate on insulin responsiveness to glucose and tissue responsiveness to insulin in relation to feeding in sheep

Sano

Terashima²

1998

Reprod. Nutr. Dev.

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“…Insulin resistance is commonly observed during late gestation and early lactation (Prior and Christenson, 1978;Debrass et al, 1989;Faulkner and Pollock, 1990;Petterson et al, 1994). Glucose utilization by peripheral tissues is lower for pregnant animals than for non-pregnant and lactating animals (Hay et al, 1988;Nieuwenhuizen et al, 1998).…”

Section: Gestationmentioning

confidence: 99%

The Role of Exogenous Insulin in the Complex of Hepatic Lipidosis and Ketosis Associated with Insulin Resistance Phenomenon in Postpartum Dairy Cattle

2006

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As a result of a marked decline in dry matter intake (DMI) prior to parturition and a slow rate of increase in DMI relative to milk production after parturition, dairy cattle experience a negative energy balance. Changes in nutritional and metabolic status during the periparturient period predispose dairy cattle to develop hepatic lipidosis and ketosis. The metabolic profile during early lactation includes low concentrations of serum insulin, plasma glucose, and liver glycogen and high concentrations of serum glucagon, adrenaline, growth hormone, plasma beta-hydroxybutyrate and non-esterified fatty acids, and liver triglyceride. Moreover, during late gestation and early lactation, flow of nutrients to fetus and mammary tissues are accorded a high degree of metabolic priority. This priority coincides with lowered responsiveness and sensitivity of extrahepatic tissues to insulin, which presumably plays a key role in development of hepatic lipidosis and ketosis. Hepatic lipidosis and ketosis compromise production, immune function, and fertility. Cows with hepatic lipidosis and ketosis have low tissue responsiveness to insulin owing to ketoacidosis. Insulin has numerous roles in metabolism of carbohydrates, lipids and proteins. Insulin is an anabolic hormone and acts to preserve nutrients as well as being a potent feed intake regulator. In addition to the major replacement therapy to alleviate severity of negative energy balance, administration of insulin with concomitant delivery of dextrose increases efficiency of treatment for hepatic lipidosis and ketosis. However, data on use of insulin to prevent these lipid-related metabolic disorders are limited and it should be investigated.

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Metabolic responses to euglycaemic hyperinsulinaemia in lactating and non-lactating sheep in vivo

Cited by 36 publications

References 31 publications

Combined effect of salinomycin and feeding on whole body glucose kinetics in sheep fed a high-concentrate diet

Combined effect of salinomycin and feeding on whole body glucose kinetics in sheep fed a high-concentrate diet

The effect of supplemental propionate on insulin responsiveness to glucose and tissue responsiveness to insulin in relation to feeding in sheep

The Role of Exogenous Insulin in the Complex of Hepatic Lipidosis and Ketosis Associated with Insulin Resistance Phenomenon in Postpartum Dairy Cattle

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