Metabolic syndrome and gender differences in postprandial lipaemia

Kolovou, Genovefa; Anagnostopoulou, Katherine K.; Pavlidis, Antonis N.; Salpea, Klelia D.; Iraklianou, Stella; Hoursalas, Ioannis; Mikhailidis, Dimitri P.; Cokkinos, Dennis V.

doi:10.1097/01.hjr.0000224490.10845.26

Cited by 36 publications

(32 citation statements)

References 26 publications

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“…Postprandial lipemia is an independent risk factor for heart disease [4,5]. Oxidative stress and inflammation play a pivotal role in atherogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…Postprandial lipemia is an independent risk factor for CVD, and a prominent feature in diabetes and MetS [4,5]. Epidemiologic studies suggest that postprandial perturbations are involved in the pathogenesis of diabetic vasculopathies [4,5]. Oxidative stress may be an important mechanism by which postprandial lipemia alters vascular function [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…Epidemiologic studies suggest that postprandial perturbations are involved in the pathogenesis of diabetic vasculopathies [4,5]. Oxidative stress may be an important mechanism by which postprandial lipemia alters vascular function [4][5][6]. High-fat meals seem to be particularly damaging to the vasculature.…”

Section: Introductionmentioning

confidence: 99%

“…The magnitude of postprandial lipemia is an independent risk factor for CVD and has been suggested to be predictive of risk for myocardial infarction. Postprandial lipemia is an independent risk factor for CVD, and a prominent feature in diabetes and MetS [4,5]. Epidemiologic studies suggest that postprandial perturbations are involved in the pathogenesis of diabetic vasculopathies [4,5].…”

Section: Introductionmentioning

confidence: 99%

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High-fat, energy-dense, fast-food–style breakfast results in an increase in oxidative stress in metabolic syndrome

et al. 2008

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The metabolic syndrome (MetS) is associated with an increased incidence of diabetes and coronary heart disease. Postprandial lipemia is a prominent feature of dyslipidemia in both type 2 diabetes mellitus and MetS and is also associated with coronary heart disease. Oxidative stress and inflammation are pivotal in all stages of atherosclerosis; however, there is a paucity of data on postprandial oxidative stress and inflammation in subjects with MetS. Thus, the primary aim of this study was to compare the postprandial effects of an energy-dense, high-fat, fast-food-style (FFS) meal with an American Heart Association (AHA)-recommended heart-healthy meal on biomarkers of oxidative stress and inflammation in subjects with MetS. A total of 11 subjects with MetS completed the study. Glucose levels were significantly increased 2 hours after both FFS and AHA diets (P <.0001), and high-density lipoprotein cholesterol levels significantly decreased in FFS diet but not in the AHA diet (P for interaction <.05). Total triglyceride levels significantly increased postprandially only in the FFS meal but not in the AHA meal (P for interaction =.03). Plasma thiobarbituric acid reactive substances and malondialdehyde + hydroxynonenal increased significantly with time in both dietary groups, and the postprandial increase was greater in the FFS diet compared to the AHA diet (P <.0005). Serum high-sensitivity C-reactive protein, interleukin 6, and tumor necrosis factor levels did not change with time or dietary treatment. The postprandial increase in interleukin 1b was significantly higher with the FFS meal, thus resulting in significant differences between both treatments (P for interaction = .03). Thus, in subjects with MetS, consumption of an energy-dense, fatty meal (FFS breakfast) results in increased postprandial oxidative stress compared to a heart-healthy meal (AHA).

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“…Postprandial lipemia is an independent risk factor for heart disease [4,5]. Oxidative stress and inflammation play a pivotal role in atherogenesis.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

High-fat, energy-dense, fast-food–style breakfast results in an increase in oxidative stress in metabolic syndrome

et al. 2008

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“…Furthermore, 75% of women used oral contraceptives, which are known to influence the metabolic measurements. Previous studies have shown that women have lower postprandial TG levels [14], probably because of the presence of oestrogens and progestagens [15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Abnormal lipid profile and hyperinsulinaemia after a mixed meal: additional cardiovascular risk factors in young adults born preterm

et al. 2008

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Aims/hypothesis Low birthweight in infants born at term is related to the presence of the metabolic syndrome as an adult. Individuals born preterm invariably have low birthweights and may develop the metabolic syndrome as well. Although high BP, glucose intolerance and insulin resistance have been documented, dyslipidaemia has never been reported in individuals born preterm. Methods In three groups of young adults [29 participants from the POPS (Project On Premature and Small for Gestational Age Infants) cohort born preterm appropriate for gestational age (POPS-AGA), 28 participants from the POPS cohort born preterm small for gestational age (POPS-SGA) and 30 individuals born at term with normal birthweight (CON)] we investigated fasting lipids as well as postprandial responses during a mixed meal test. The relationship between fasting and postprandial measurements and insulin sensitivity, measured by the hyperinsulinaemic clamp, was investigated. Results Preterm participants had higher BP than CON individuals. Postprandial triacylglycerol levels were increased in POPS-SGA men. POPS-SGA individuals were hyperinsulinaemic during the mixed meal test. Conclusions/interpretation The mixed meal test provides additional information on cardiovascular risk factors. Postprandial triacylglycerol levels are increased in POPS-SGA men. Postprandial hyperinsulinaemia is found in POPS-SGA individuals.

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Apolipoprotein E polymorphism, age and coronary heart disease

Kolovou

Anagnostopoulou

2007

Ageing Research Reviews

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Metabolic syndrome and gender differences in postprandial lipaemia

Abstract: Men had a more pronounced postprandial hypertriglyceridaemia and seem to have delayed TG clearance.

Cited by 36 publications

References 26 publications

High-fat, energy-dense, fast-food–style breakfast results in an increase in oxidative stress in metabolic syndrome

High-fat, energy-dense, fast-food–style breakfast results in an increase in oxidative stress in metabolic syndrome

Abnormal lipid profile and hyperinsulinaemia after a mixed meal: additional cardiovascular risk factors in young adults born preterm

Apolipoprotein E polymorphism, age and coronary heart disease

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