2013
DOI: 10.5455/jppa.20130317071355
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Metabolic Syndrome: Definition and Pathophysiology and #8211; the discussion goes on!

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Cited by 27 publications
(24 citation statements)
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“…4 Penyebab lain terdiri dari dislipidemia aterogenik, peningkatan tekanan darah dan kadar glukosa plasma, keadaan prothrombotic, serta proinflamasi. 4,8 Beberapa faktor perilaku pekerja diketahui juga berkontribusi terhadap timbulnya sindrom metabolik. Faktor tersebut antara lain faktor pekerjaan yang memicu pekerja cenderung untuk berperilaku sedenter (tidak banyak aktivitas fisik), pola makan tidak sehat, perilaku merokok, stres, dan lain-lain.…”
unclassified
“…4 Penyebab lain terdiri dari dislipidemia aterogenik, peningkatan tekanan darah dan kadar glukosa plasma, keadaan prothrombotic, serta proinflamasi. 4,8 Beberapa faktor perilaku pekerja diketahui juga berkontribusi terhadap timbulnya sindrom metabolik. Faktor tersebut antara lain faktor pekerjaan yang memicu pekerja cenderung untuk berperilaku sedenter (tidak banyak aktivitas fisik), pola makan tidak sehat, perilaku merokok, stres, dan lain-lain.…”
unclassified
“…Selain itu, penelitian sebelumnya oleh Attia [1] menyatakan bahwa β-karoten selama 2 bulan dapat menurunkan kadar glukosa darah pada tikus yang menderita diabetes secara signifikan. Diabetes melitus merupakan penyakit yang dipengaruhi oleh gangguan sistem metabolik yang ditandai dengan terjadinya resistensi insulin [21]. Konsep modern mengenai sindrom metabolisme bermula pada tahun 1988 oleh Reaven dengan postulatnya yaitu resistensi insulin merupakan penyebab intoleransi glukosa, hiperinsulinemia, peningkatan kadar very low density lipoprotein (VLDL), penurunan high density lipoprotein (HDL), dan hipertensi [15].…”
Section: Pendahuluanunclassified
“…In 2012, Zhao et al published a meta-analysis which included a subset of the aforementioned studies (N = 12) which excluded a report that did not collect data on heme and non-heme iron intake (Table 8) Reaven's syndrome, Syndrome X, CHAOS (i.e., coronary artery disease, hypertension, atherosclerosis, obesity and stroke), insulin resistance syndrome) the aforementioned cluster of metabolic abnormalities has become known as the metabolic syndrome (400,401). The benefit of utilizing the term metabolic syndrome is not so much in identifying patients with a general risk of cardiovascular disease and T2DM, but more so with the identification of specific subgroups of individuals with a shared pathophysiology (402).…”
Section: Iron and T2dmmentioning
confidence: 99%
“…Pathophysiology Although the etiology of metabolic syndrome is uncertain, several hypotheses implicate insulin resistance, visceral adiposity and low-grade inflammation as the drivers of each downstream component (400). As mentioned previously, insulin resistance has been defined as the inability of insulin to stimulate adequate glucose uptake in muscle and adipose tissue as well as the inability of insulin to suppress hepatic glucose output (415).…”
Section: Iron and T2dmmentioning
confidence: 99%