Metabolic syndrome: yet another co-morbidity gastric bypass helps cure

Madan, Atul K.; Orth, Whitney S.; Ternovits, Craig A.; Tichansky, David S.

doi:10.1016/j.soard.2005.09.014

Cited by 60 publications

(43 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…15 In two series of bariatric surgery patients with Met Syn (average BMIs 43-47 kg/m 2 ), remission rates of at least 95% were reported after weight losses of about 32-40%. 18,19 Limitations of the present study include the relatively small sample size, paucity of men, over-representation of Caucasian individuals and lack of outcome data for patients who did not complete the program. There was no control group; it should be remembered, however, that the purpose was not to judge whether this weight loss program was an efficacious treatment for Met Syn, but rather to assess the extent of remission among patients completing a defined weight loss program.…”

Section: Remission Of Metabolic Syndrome Jd Lundgren Et Almentioning

confidence: 96%

“…11 Finally, among patients undergoing weight loss surgery, rates of resolution of Met Syn as high as 95% have been reported. 18,19 The studies noted earlier reported results on remission rates of Met Syn in weight loss interventions by examining very intensive research protocols, pharmacotherapy weight loss clinical trials or weight loss surgery. In the current study, we examined remission rates of Met Syn among obese adults enrolled in a relatively brief, moderate-intensity, fee-forservice low-calorie lifestyle change weight loss intervention.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Remission of metabolic syndrome following a 15-week low-calorie lifestyle change program for weight loss

et al. 2008

View full text Add to dashboard Cite

Objective: To evaluate the rate of remission of metabolic syndrome (Met Syn) among patients undergoing a brief, low-calorie lifestyle change weight loss intervention and to compare the baseline characteristics of patients who were remitted and not remitted from Met Syn at post-treatment. Research Methods and Procedures: Obese adults (N ¼ 36) meeting criteria for Met Syn enrolled in an outpatient fee-forservice behavioral weight loss intervention. Participants were assessed on key Met Syn variables (waist circumference, blood pressure, triglycerides, high-density lipoprotein (HDL) cholesterol and fasting blood glucose) at pre-and post-treatment. Results: The majority of patients (61%) responded to treatment after a 9.9% mean weight loss. Although Met Syn responders did not differ significantly from Met Syn non-responders on any baseline Met Syn criterion variable, responders had significantly lower baseline body mass indices (BMI; kg/m 2 ) and met criteria for fewer baseline Met Syn variables. As expected, Met Syn responders, compared with Met Syn non-responders, had significantly lower post-treatment waist circumference, systolic and diastolic blood pressures, triglycerides and fasting blood glucose. Patient groups did not differ significantly on weight lost (kg or %), or on the proportion of patients losing X10% of initial body weight. Discussion: In a community population, Met Syn responds to weight loss through a low-calorie lifestyle intervention; for some patients, however, the recommended 10% weight loss may not be enough for Met Syn remission.

show abstract

Section: Remission Of Metabolic Syndrome Jd Lundgren Et Almentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Remission of metabolic syndrome following a 15-week low-calorie lifestyle change program for weight loss

et al. 2008

View full text Add to dashboard Cite

show abstract

“…60,61 Bariatric surgical procedures have also been shown to be effective in reversing the prevalence of the metabolic syndrome or the insulin resistance syndrome as defined by National Cholesterol Education Program Adult Treatment Panel III criteria. 62,63 This perhaps is not surprising given the fact that many of the manifestations of the metabolic syndrome (waist circumference, blood pressure, high fasting blood sugar, high fasting triglycerides, low fasting highdensity lipoprotein [HDL] cholesterol) can be traced back to excess adiposity and insulin resistance.…”

Section: Diabetes Mellitusmentioning

confidence: 99%

Bariatric Surgery and Cardiovascular Risk Factors

Poirier¹,

Cornier²,

Mazzone³

et al. 2011

Circulation

300

134

View full text Add to dashboard Cite

T he rate of obesity is rising logarithmically, especially in those with severe obesity (body mass index [BMI] Ͼ40 kg/m 2 ). Cardiologists, endocrinologists, internists, family practitioners, and most healthcare professionals are increasingly confronted with the severely obese patient and with postoperative bariatric patients because obesity is associated with significant morbidity and increased mortality. In addition, more adolescents these days are severely obese. Substantial long-term successes of lifestyle modifications and drug therapy have been disappointing in this population. The National Institutes of Health has suggested that surgical therapy be proposed to those patients with BMI Ͼ40 kg/m 2 or Ͼ35 kg/m 2 with serious obesity-related comorbidities such as systemic hypertension, type 2 diabetes mellitus, and obstructive sleep apnea. When indicated, surgical intervention leads to significant improvements in decreasing excess weight and comorbidities that can be maintained over time. These include diabetes mellitus, dyslipidemia, liver disease, systemic hypertension, obstructive sleep apnea, and cardiovascular dysfunction. Recent prospective, nonrandomized, observational, or case-control population studies have also shown bariatric surgery to prolong survival in the severely obese. Different types of bariatric procedures are being performed. Historically, operative mortality was between 0.1% and 2.0% with more recent data not exceeding 1%. Early complications include pulmonary embolus (0.5%), anastomotic leaks (1.0% to 2.5%), and bleeding (1.0%). Late complications include anastomotic stricture, anastomotic ulcers, hernias, band slippage, and behavioral maladaptation. The number of bariatric operations being performed is increasing tremendously as a result of increasing medical need and the evolution of safer surgical techniques and guidelines. Currently, bariatric surgery should be reserved for patients who have severe obesity in whom efforts at medical therapy have failed and an acceptable operative risk is present.

show abstract

“…everal studies have demonstrated the benefits of massive weight reduction following Roux-en-Y gastric bypass (RYGBP) on the metabolic syndrome (1)(2)(3). However, the time course of the effects of RYGBP on the metabolic syndrome components and its potential underlying mechanisms has not been reported.…”

mentioning

confidence: 99%