Metabolically healthy obese women have longer telomere length than obese women with metabolic syndrome

Molli, Andrea Elena Iglesias; Panero, Julieta; Santos, Patricia Carolina Dos; González, Claudio; Vilariño, Jorge; Sereday, Marta; Cerrone, Gloria Edith; Slavutsky, Irma; Frechtel, Gustavo Daniel

doi:10.1371/journal.pone.0174945

Cited by 17 publications

(12 citation statements)

References 45 publications

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“…Moreover, in the present study, ATL was inversely correlated with BMI. This finding is consistent with several prior studies carried out by our group which showed increases in BMI and the presence of obesity as major determinants of telomere shortening [ 33 , 34 ].…”

Section: Discussionsupporting

confidence: 93%

Leukocyte telomere length is associated with iron overload in male adults with hereditary hemochromatosis

et al. 2020

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Background: Hereditary hemochromatosis (HH) is a primary iron overload (IO) condition. Absolute telomere length (ATL) is a marker of cellular aging and DNA damage associated with chronic diseases and mortality.  Aim: To evaluate the relationship between ATL and IO in patients with HH.</p>  Methods: Cross-sectional study including25 patients with HH: 8 with IO and 17 without IO (ferritin< 300ng/ml) and 25 healthy controls. Inclusion criteria were: age>18 years, male sex and HH diagnosis. Patients with diabetes or other endocrine and autoimmune diseases were excluded. ATL was measured by real-time PCR.</p>  Results: HH patients with IO were older (p<0.001) and showed higher ferritin concentration (p<0.001). Patients with HH, disregarding the iron status, showed higher glucose and BMI than controls (both p<0.01). ATL was shorter in patients with IO than controls [with IO: 8 (6-14), without IO: 13 (9-20),and controls: 19 (15-25) kilobase pairs, p<0.01];with a linear trend within groups (p for trend<0.01). Differences in ATL remained statistically significant after adjusting by age, BMI and glucose(p<0.05).</p>  Discussion: Patients with IO featured shorter ATL while patients without IO showed only mild alterations vs. controls. Screening for IO is encouraged to prevent iron-associated cellular damage and early telomere attrition.

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Section: Discussionsupporting

confidence: 93%

Leukocyte telomere length is associated with iron overload in male adults with hereditary hemochromatosis

et al. 2020

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“…A third misconception is that obesity and chronic disease are the same phenomenon. Rather, it must be pointed out that 20% of individuals who are obese are metabolically healthy ( 7 ) with normal lifespan and health span, and expected biochemical markers of aging, such as normal length telomeres ( 8 ). Conversely.…”

Section: Introductionmentioning

confidence: 99%

The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the liver, and support the brain

Harlan

Gow

Kornstädt³

et al. 2023

Front. Nutr.

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Ultraprocessed food is established as a metabolic disruptor acting to increase adiposity, reduce mitochondrial efficiency, drive insulin resistance, alter growth, and contribute to human morbidity and mortality. Consumer packaged goods (CPG) companies are beginning to understand the detrimental impact of the food they market, and have employed substitution strategies to reduce salt, sugar, and fat. However, the harms of ultraprocessed foods are far more complex than any single component, and are not ameliorated by such simple substitutions. Over the past 2 years, the authors have worked with the Kuwaiti Danish Dairy Company (KDD) to conduct a comprehensive scientific evaluation of their entire commercial food and beverage portfolio. Assay of the macronutrients, micronutrients, additives, and toxins contained in each of their products was undertaken to determine the precise nature of each product’s ingredients as well as the health impacts of processing. The authors formed a Scientific Advisory Team (SAT) and developed a tiered “Metabolic Matrix” founded in three science-based principles: (1) protect the liver, (2) feed the gut, and (3) support the brain. The Metabolic Matrix categorizes each product and provides the criteria, metrics, and recommendations for improvement or reformulation. Real-time consultation with the KDD Executive and Operations teams was vital to see these procedures through to fruition. This scientific exercise has enabled KDD to lay the groundwork for improving the health, well-being, and sustainability of their entire product line, while maintaining flavor, economic, and fiscal viability. This process is easily transferrable, and we are sharing this effort and its approaches as a proof-of-concept. The key aim of our work is to not only make ultraprocessed food healthier but to urge other food companies to implement similar analysis and reformulation of their product lines to improve the metabolic health and well-being of consumers worldwide.

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“…The link between nuchal SAT accumulation, plasma insulin levels and RTL relates a specific SAT distribution pattern to an altered glucose metabolism and accelerated genomic aging, indicated by short RTL. An association between obesity and telomere physiology has been reported before 13,[30][31][32][33][34][35][36] . However, most previous studies used BMI to characterize individuals as overweight/obese or normal weight.…”

Section: Discussionmentioning

confidence: 86%

Telomere shortening associates with elevated insulin and nuchal fat accumulation

Mangge

Herrmann

Almer

et al. 2020

Sci Rep

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obesity and relative leucocyte telomere length (RtL) are both linked to accelerated aging and premature mortality. We examined if nuchal subcutaneous adipose tissue (SAt) thickness, a surrogate marker of central trunk-weighted obesity, is an independent predictor of RtL that provides information beyond BMI, metabolic and inflammatory markers. RTL and nuchal SAT thickness were determined in 362 participants of the STYJOBS/EDECTA study (STYrian Juvenile Obesity Study, Early DEteCTion of atherosclerosis), which included overweight individuals and matched eutrophic controls. fasting plasma samples were used for the measurement of leptin, resistin, adiponectin, glucose, insulin, highsensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), liver enzymes, creatinine, cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, oxidized LDL, triglycerides, homocysteine and uric acid. furthermore, all participants underwent carotid artery ultrasound. obese individuals had markedly higher body mass index (BMi), nuchal SAt thickness, hip and waist circumferences and carotid intima media thickness (iMt) than eutrophic controls. in addition, they showed typical biochemical abnormalities related to energy metabolism, systemic inflammation and liver function. RTL was inversely correlated with nuchal SAT thickness, IMT, hs-CRP, alkaline phosphatase, insulin, resistin, and leptin. positive correlations were seen with homocysteine and creatinine. Stepwise linear regression analyses identified nuchal SAT thickness and insulin as the only significant predictors of RTL. In conclusion, nuchal SAT thickness is a robust predictor of RTL that provides information beyond traditional obesity-related metabolic and inflammatory biomarkers. This suggests an important role of fat depots at the neck for accelerated telomere shortening.

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Metabolically healthy obese women have longer telomere length than obese women with metabolic syndrome

Cited by 17 publications

References 45 publications

Leukocyte telomere length is associated with iron overload in male adults with hereditary hemochromatosis

Leukocyte telomere length is associated with iron overload in male adults with hereditary hemochromatosis

The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the liver, and support the brain

Telomere shortening associates with elevated insulin and nuchal fat accumulation

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