Metabolically healthy polycystic ovary syndrome (MH-PCOS) and metabolically unhealthy polycystic ovary syndrome (MU-PCOS): a comparative analysis of four simple methods useful for metabolic assessment

Abstract

The results will facilitate the early recognition of cardiometabolic risk in women with PCOS before they develop overt metabolic syndrome.

Influence of a positive family history of both type 2 diabetes and PCOS on metabolic and endocrine parameters in a large cohort of PCOS women

“…Elevated VAI was defined as VAI O1.675 as described previously (11). Insulin resistance was estimated using the homeostatic model assessment-insulin resistance (HOMA-IR) and was assumed for levels O2.5.…”

“…Quantitative insulin sensitivity check index (QUICKI) was used for estimation of insulin sensitivity (11). We further calculated insulin sensitivity index Matsuda (ISI (Matsuda)) as an insulin sensitivity index that reflects a composite estimate of hepatic and muscle insulin sensitivity determined from OGTT data ðISI ðMatsudaÞ Z 10 000=OððFG !…”

“…There is accumulating evidence suggesting that central obesity is the key factor in the development of metabolic and cardiovascular risk in PCOS women (7,8,9). In this context, several indices such as lipid accumulation product (LAP) (8,10) and visceral adiposity index (VAI) (11) have been shown to be associated with an increased risk of insulin resistance, prediabetes and type 2 diabetes mellitus (T2DM) in PCOS as well as in other cohorts. Further, there is evidence showing that a positive family history (FHx) of T2DM, as a reflection of genetic risk, is associated with an increased risk of the development of T2DM in PCOS women (12,13,14).…”

What do we know about metabolic syndrome in adolescents with PCOS?

“…For this reason, this phenotype is said to have the lowest cardiovascular risk compared to other phenotypes (2). Amato et al (45) conducted a study in order to verify a method for distinguishing the metabolic health of women of reproductive age with PCOS. The visceral adiposity index is suggested as an easy and successful method for the assessment of metabolically unhealthy women and the detection of cardiometabolic risk factors.…”

Visceral adiposity index correlation with Rotterdam criteria in patients with polycystic ovary syndrome

“…10 Recent studies evaluated VAI in women with PCOS and reported that VAI correlated with insulin resistance, differentiate the "metabolically healthy polycystic ovary syndrome" from the "metabolically unhealthy polycystic ovary syndrome" Also VAI replace visceral CT scan as a marker for visceral adiposity. [11][12][13] VAI is considered a predictor of clinical severity and therapeutic outcome of PCOS.…”