Metabolism and detoxification of pesticides in plants

Zhang, Jing Jing; Yang, Hong

doi:10.1016/j.scitotenv.2021.148034

Cited by 136 publications

(83 citation statements)

References 159 publications

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“…Authors assumed different susceptibility of both kinds of mitochondria with different activities of protective antioxidant agents [ 71 ].In general, plants can detoxify the pesticides through multi-specific pathways. The reactions are primarily divided into three canonical phases, including phase I metabolism (pesticide metabolism by cytochrome P 450s , hydrolases, laccases), phase II conjugation (the metabolic pathway of S—thiols conjugates, detoxification by glutathione S—transferases and glycosyltransferases), and phase III transport (metabolism of pesticides by ATP binding cassette transporters) [ 72 ]. We recently showed that plant mitochondria, which oxidized NADH by complex I (not alternative NAD(P)H dehydrogenases), was more prone to pesticide-induced inhibition of the rate of O 2 consumption [ 36 ] than intact mitochondria, which oxidized of succinate [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

High Doses of Pesticides Induce mtDNA Damage in Intact Mitochondria of Potato In Vitro and Do Not Impact on mtDNA Integrity of Mitochondria of Shoots and Tubers under In Vivo Exposure

Alimova

Sitnikov

Pogorelov

et al. 2022

IJMS

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It is well known that pesticides are toxic for mitochondria of animals. The effect of pesticides on plant mitochondria has not been widely studied. The goal of this research is to study the impact of metribuzin and imidacloprid on the amount of damage in the mtDNA of potato (Solanum tuberosum L.) in various conditions. We developed a set of primers to estimate mtDNA damage for the fragments in three chromosomes of potato mitogenome. We showed that both metribuzin and imidacloprid considerably damage mtDNA in vitro. Imidacloprid reduces the rate of seed germination, but does not impact the rate of the growth and number of mtDNA damage in the potato shoots. Field experiments show that pesticide exposure does not induce change in aconitate hydratase activity, and can cause a decrease in the rate of H2O2 production. We can assume that the mechanism of pesticide-induced mtDNA damage in vitro is not associated with H2O2 production, and pesticides as electrophilic substances directly interact with mtDNA. The effect of pesticides on the integrity of mtDNA in green parts of plants and in crop tubers is insignificant. In general, plant mtDNA is resistant to pesticide exposure in vivo, probably due to the presence of non-coupled respiratory systems in plant mitochondria.

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Section: Discussionmentioning

confidence: 99%

High Doses of Pesticides Induce mtDNA Damage in Intact Mitochondria of Potato In Vitro and Do Not Impact on mtDNA Integrity of Mitochondria of Shoots and Tubers under In Vivo Exposure

Alimova

Sitnikov

Pogorelov

et al. 2022

IJMS

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“…Pesticides are indispensable chemical agents in modern agricultural production to control diseases, insect pests, and weeds, and also play an important role in the yield and quality of crops ( Huang et al, 2021 ; Zhang and Yang, 2021 ). However, the excessive use of pesticides causes great harm to the natural environment and induces pesticide stress, which affects the normal physiological and metabolic activities of crops.…”

Section: Environmental Pollutionmentioning

confidence: 99%

Effects of Plant Hormones, Metal Ions, Salinity, Sugar, and Chemicals Pollution on Glucosinolate Biosynthesis in Cruciferous Plant

Liu

Wang

et al. 2022

Front. Plant Sci.

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Cruciferous vegetable crops are grown widely around the world, which supply a multitude of health-related micronutrients, phytochemicals, and antioxidant compounds. Glucosinolates (GSLs) are specialized metabolites found widely in cruciferous vegetables, which are not only related to flavor formation but also have anti-cancer, disease-resistance, and insect-resistance properties. The content and components of GSLs in the Cruciferae are not only related to genotypes and environmental factors but also are influenced by hormones, plant growth regulators, and mineral elements. This review discusses the effects of different exogenous substances on the GSL content and composition, and analyzes the molecular mechanism by which these substances regulate the biosynthesis of GSLs. Based on the current research status, future research directions are also proposed.

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“…8,9 According to the reasonable reaction site of FSF, S-glycosylation is more likely to occur. 7 Sglycosylation is a conjugation with less reports. So far, plant natural S-glycosylation has been verified to occur on the pathway of glucosinolate biosynthesis.…”

Section: Introductionmentioning

confidence: 99%

“…The metabolism of hazardous xenobiotic in plants often goes through four ways, including phase I (simple functional group changes), phase II (conjugation with plant endogenous compounds), phase III (transport), and noncanonical phase IV (other reactions). , This article will focus on the structural changes of FSF and the formation of their conjugates in different tissues of tomato. In plants, xenobiotics with hydroxyl, carboxyl, or amino groups can lose a water molecule through glycosylation to form a conjugate to increase their solubility in the cytoplasm for transport and sequestration . For example, isoproturon, an herbicide, proceeds O - and N -glycosylation in rice and wheat. , According to the reasonable reaction site of FSF, S -glycosylation is more likely to occur …”

Section: Introductionmentioning

confidence: 99%

S-Glycosylation of Fluensulfone in Tomatoes: An Important Way of Fluensulfone Metabolism

Zhang

Cao

et al. 2021

J. Agric. Food Chem.

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Fluensulfone (FSF) becomes increasingly popular because of its nonfumigation application method. However, studies on the metabolic mechanism of FSF in plants are lacking. Here, tomato seedling was cultivated in hydroponic media to investigate the connection among FSF’s metabolism in tomato, the regulation of tomato endogenous glycosides, and the elimination of hydrogen peroxide in tomato cells. The accumulation of FSF was only detected in the lower stems of tomatoes; FSF was mainly metabolized into S-glycosylated conjugates in the roots, and the roots were the tissues with the highest metabolite content; and no FSF and metabolites were detected in the upper leaves. In response to FSF stress (2 mg/L for 7 d), the content of sugar and glycosides in the stems of tomato seedlings significantly increased. The amount of some compounds on the pathway related to glucose was affected by FSF. The three precursor compounds (homomethioine, isoleucine, and l-tyrosine) in the pathway of glucosinolate biosynthesis increased significantly under the stress of FSF, which indicates that FSF may compete with them for UGT74B1. Besides, FSF-induced flavonoid glycosides may play a role in the process of removing hydrogen peroxide. This research provides inspiration for the fate of many xenobiotics containing sulfonyl groups in plants.

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Metabolism and detoxification of pesticides in plants

Cited by 136 publications

References 159 publications

High Doses of Pesticides Induce mtDNA Damage in Intact Mitochondria of Potato In Vitro and Do Not Impact on mtDNA Integrity of Mitochondria of Shoots and Tubers under In Vivo Exposure

High Doses of Pesticides Induce mtDNA Damage in Intact Mitochondria of Potato In Vitro and Do Not Impact on mtDNA Integrity of Mitochondria of Shoots and Tubers under In Vivo Exposure

Effects of Plant Hormones, Metal Ions, Salinity, Sugar, and Chemicals Pollution on Glucosinolate Biosynthesis in Cruciferous Plant

S-Glycosylation of Fluensulfone in Tomatoes: An Important Way of Fluensulfone Metabolism

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